李子健 博导，研究员

  心血管受体信号调节机制；心血管疾病与受体信号调节；心血管受体创新药物的发现及研究。
  个人简介北京大学第三医院血管医学研究所、分子心血管学教育部重点实验室、卫生部心血管分子生物学与调节肽重点实验室、心血管受体研究北京市重点实验室研究员。国家自然科学基金同行评议专家。Circulation, oncotarget，Molecular Medicine、Oxidative Medicine and Cellular Longevity 、Clinical and Experimental Pharmacology and Physiology (CEPP), Acta Pharmaceutica Sinica， 《中国生物化学与分子生物学报》， 《中国医学科学院学报》， 《生理学报》， 《生理科学进展》等杂志审稿专家。作为课题负责人承担课题各级14项，包括：持国家自然科学基金（5项）、重大科学研究计划A类项目（骨干）、国家“973”项目（骨干）、北京市自然科学基金，中国博士后科学基金、国家留学基金委委员会归国人员启动基金、 “重大新药创制”科技重大专项目子课题等课题，总金额近600万元。公开发表研究论文100余篇，作为通讯作者在The FASEB Journal、JBC、Oncotarget、British journal of pharmacology等杂志发表系列SCI文章31篇。译著3部（作为副主译或译者）。申请国家发明专利7项，获得国家发明专利3项。获省部级科技进步一等奖2项。2006获第七届“河北省优秀青年志愿者特别奖”，第七届“河北省杰出青年志愿服务集体特别奖”。 2010年获美国西屋/西门子科学竞赛优秀导师奖。2012年获北京大学医学部优秀教师。教育经历2008.1－2010.1 美国Emory大学药学系 博士后2003.9－2005.9 北京大学 第三医院心内科血管医学研究所，教育部重点实验室 博士后 2000.9－2003.7 吉林大学 白求恩医学部 博士生1996.9－1999.7 吉林大学 生命科学学院 硕士生1989.9－1992.7 长春医学高等专科学校 学生工作经历2014.8－ 今 北京大学第三医院血管医学研究所 研究员2008.1－2010.1 美国Emory大学药学系 博士后2007.8－2014.8 北京大学第三医院血管医学研究所 副研究员2005.9－2007.7 北京大学第三医院血管医学研究所 助理研究员2004.9－2005.9 北京市药品监督管理局东城分局 副局长（挂职）2003.9－2005.9 北京大学第三医院心内科血管医学研究所 博士后 北京大学医学部博士后联谊会 理事长 第十六届、十七届北京大学博士后联谊会 副理事长 第十五届、十六届北京博士后联谊会 科技部部长1992.7－2003.9 白求恩医科大学/吉林大学第一医院 临床药理 代表性科研成果在国际上首次发现肾上腺素受体信号网络新的调节蛋白HIP-55及其在心血管疾病中的作用，相关研究已在The FASEB Journal 、JBC、Molecular BioSystems、Oncotarget等国际著名杂志发表系列文章。研究成果已申请4项国家发明专利，其中1项已获得国家发明专利授权。研究成果对揭示受体相关心血管疾病的发病机制和寻找新的受体功能选择性物靶点具有重要意义。围绕在心血管受体的研究发现，结合蛋白质组学、代谢组学的新技术方法和传统中药的理念进行新药研发。合作发现的一个全新化合物丹参素异丙酯（IDHP）、生长分化因子-15（GDF-15)等药物，并首次报道它们在心脏保护中的作用。研究论文已发表在British Journal of Pharmacology、JBC等国际著名杂志。研究策略也在《Science》杂志专题中发表（Multidisciplinary Approaches for Studying Traditional Medicine: A novel drug discovery strategy inspired by traditional medicine philosophies. Science. 2015: 337：S38-S39)。学术兼职中国病理生理学会受体专业委员会青年委员会主任委员（2014年）中国生物化学与分子生物学会蛋白质组学专业委员会委员（2011年）中国蛋白质组青年委员会委员（2014年）北京药理学会心脑血管专业委员会副主任委员（2014年）Molecular Pharmacology（IF：4.883）编委（Editorial Board Member）（2013年）《基础医学与临床杂志》编委（2012年）《中国心血管杂志》编委（2012年）所获奖励1）2005年获吉林省科技进步一等奖；2）2006第七届“河北省优秀青年志愿者特别奖”；3）2010年度美国西门子/西屋科学竞赛优秀导师奖；4）2012年获北京大学医学部优秀教师；5）2014年获陕西省高等学校科学技术一等奖；近5年发表的论文：* Corresponding author1.Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Taipin Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li* A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway. Br J Pharmacol. 2015 Mar 13. doi: 10.1111/bph.13133. [Epub ahead of print]2.Kangmin He, Rui Xing, Xiaohua Yan, Aiju Tian, Mingliang Zhang, Jinghe Yuan, Zhizhen Lv,Xiaohong Fang, Zijian Li* & Youyi Zhang*. Mammalian actin-binding protein 1/HIP-55 is essential for the scission of clathrin-coated pits by regulating dynamin-actin interaction. The FASEB Journal, 2015 29(6):2495-503. 3.Cheng, Yuan; Ma, Ding; Zhang, Youyi; Li, Zijian*; Geng, Li*, Cervical Squamous Cancer mRNA Profiles Reveal the Key Genes of Metastasis and Invasion. European journal of gynaecological oncology. 2015,3:309-317 4.He K, Yan X, Li N, Dang S, Xu L, Zhao B, Li Z, Lv Z, Fang X, Zhang Y, Chen YG. Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes. Cell Res. 2015;25(6):738-52.5.Shi Z, Park HR, Du Y, Li Z, Cheng K, Sun S, Li Z, Fu H, Khuri FR. Cables1 Complex Couples Survival Signaling to the Cell Death Machinery. Cancer Res. 2015;75(1):147-58 6.田爱炬，李子健* 14-3-3/HIP-55复合体增强HIP-55蛋白质稳定性. 北京大学学报(医学版). 2015，47(2):197-201.7.田爱炬，李子健* β-肾上腺素受体调节蛋白及其作用. 生理科学进展. 2015, 46（2）:81-86.8.Hongnan Ye, Youyi Zhang, Li Geng* and Zijian Li*. Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration. International Journal of Oncology. 2015. 46: 757-763. 9.Zenghui Meng, Chengzhi Yang, Jimin Wu, Aiju Tian, Youyi Zhang, Wei Gao, Zijian Li*and Lijun Guo*. Genetic background modulates myocardial ischemic reperfusion injury in mouse model. Experimental & Clinical Cardiology. 2014(20) 11: 6689-6703.10.Rui Xing†, Shanshan Li†,Youyi Zhang, Chunyang Xiong* and Zijian Li*. HIP-55 negatively regulates myocardial contractility at the single-cell level. Journal of Biomechanics. 2014. 14. 2715–2720. 11.Ning Liu†, Rui Xing†, Chengzhi Yang, Aiju Tian, Zhizhen Lv, Ningning Sun, Xiang Gao, Youyi Zhang and Zijian Li* HIP-55/DBNL–dependent regulation of adrenergic receptor mediates ERK1/2 proliferative pathway. Molecular BioSystems. 2014.10(6): 1932--1939. 12. Zijian Li*, Hae Ryon Park, Zhi Shi, Zenggang Li, Cau Dinh Pham, Yuhong Du, Fadlo R. Khuri, Youyi Zhang, Qide Han, and Haian Fu*. Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. Oncotarget. 2014,5(10):3197-209. 13.Haiyan Lu†, Aiju Tian†, Jimin Wu, Chengzhi Yang, Rui Xing,Pu Jia, Lingjian Yang, Youyi Zhang, Xiaohui Zheng* and Zijian Li* Danshensu inhibits β-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis. biological & pharmaceutical bulletin. 2014, 37(6) 961–967 14.LIU Ning, SUN Ningning, GAO Xiang, LI Zijian*. Phosphosite Mapping of HIP-55 Protein in Mammalian Cell. Int. J. Mol. Sci. 2014, 15(3), 4903-4914. 15.Xu Xinye, Nie Ying, Wang Fangfang, Bai yan, Lu Zhizhen, Yu Haiyi, Zhang youyi, Li Zijian*, Gao Wei*. GDF-15 blocks norepinephrine-induced myocardial hypertrophy via a novel pathway involving inhibition of EGFR transactivation. J. Biol. Chem. 2014, 289:10084-10094. 16.Chengzhi Yang, Zenggang Li, Zhi Shi, Rui Xing, Jiming Wu, Youyi Zhang, Zijian Li*. Regulation of cell survival by HIP-55 signaling network. Molecular BioSystems. 2014,10(6):1393-9. 17.Zijian Li, Wanchun Sun, Donglin Wu, Xiang Gao, Ningning Sun, Ning Liu *. Mass spectrometry analysis coupled with de novo sequencing reveals amino acid substitutions in nucleocapsid protein from influenza A virus. INT J MOL SCI. 2014, 15, 2465-2474. 18.Rong Chen, Yuan Cheng, Youyi Zhang, Zijian Li*, Li Geng*. RhoC Mediates Invasion and Migration of CaSki Cells Through the Rho-Associated Serine-Threonine Protein Kinase 1 Signaling Pathway. International Journal of Gynecological Cancer. 2014; 24(2):184-91.19.杨承志，田爱炬，孟增慧，吴济民，张幼怡，郭丽君，李子健*. 异丙肾上腺素诱导FVB/N小鼠心脏肥大模型的建立. 北京大学学报(医学版). 2014,46(6):105-109.20.殷倩，鲁海燕，杨承志，田爱炬，杨秋香，张幼怡，郑晓晖*，李子健*，郑小璞*. 肾上腺素受体介导心脏纤维化模型中核转录因子NF-κB活化. 北京大学学报(医学版). 2014,46(6):19-23.21.孙敏，于海奕，张幼怡，吕志珍，高炜，李子健*. 成年大鼠心肌细胞分离培养及兴奋-收缩耦联表征. 中国比较医学杂志. 2014,24(3):1-5.22.叶洪楠，游珂，郭艳利，张小为，耿力*，李子健*. PP16INK4a及Ki-67免疫细胞化学检测对ASC-US中高级别病变检出的意义. 肿瘤预防与治疗. 2014,27, (1) 6-11.23.孟增慧, 杨承志, 田爱炬, 吕志珍, 张幼怡, 高炜, 李子健, 郭丽君. 小鼠心肌缺血再灌注损伤模型制备及心肌梗死面积评价方法学比较. 中国心血管杂志. 2014,19(2): 123-127.24.Zhao W, Zhang F, Li Z, Yu H, Li Z, Gao W. Soluble CD40 ligand is associated with angiographic severity of coronary artery disease in patients with acute coronary syndrome. Chin Med J (Engl). 2014;127(12):2218-21.25.Zhao X, Li Q, Xiao C, Zhang Y, Bian L, Zheng J, Zheng X, Li Z, Zhang Y, Fan T. Oriented immobilisation of histidine-tagged protein and its application in exploring interactions between ligands and proteins. Anal Bioanal Chem. 2014 ;406(12):2975-85.26.Li Q, Bian L, Zhao X, Gao X, Zheng J, Li Z, Zhang Y, Jiang R, Zheng X. Immobilised Histidine Tagged β2-Adrenoceptor Oriented by a Diazonium Salt Reaction and Its Application in Exploring Drug-Protein Interaction Using Ephedrine and Pseudoephedrine as Probes. PLoS One. 2014; 18;9(4):e94955. 27.Zhao X, Li Q, Chen J, Xiao C, Bian L, Zheng J, Zheng X, Li Z, Zhang Y. Exploring drug-protein interactions using the relationship between injection volume and capacity factor. J Chromatogr A. 2014;25;1339:137-44.28.MA Ding, CHENG Yuan, ZHANG You-yi, GUO Yan-li, LI Zi-jian* and GENG Li* Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics. Chin J Cancer Res 2013;25(6):656-661. 29. Xinfeng Zhao, Qian Li, Jingjing Huang, Jianbin Zheng,Xiaohui Zheng, Zijian Li, and Youyi Zhang Effects of temperature and mobile phase composition on the interaction between berberine and immobilized b2-adrenoceptor by high performance affinity chromatography. Journal of Liquid Chromatography & Related Technologies. 2014, 37:88-98.20 LI Zijian, HE Xin, PAN Chenyu, LIU Ning. Mass Spectrometric Analysis of Phosphorylation Modification in 14-3-3 Protein. Chinese Journal of Analytical Chemistry, 2013, 41(11): 1653–1658. 21Chengzhi Yang, Hui Yang, Jimin Wu, Zenghui Meng, Rui Xing, Aiju Tian, Xin Tian, Lijun Guo, Youyi Zhang,Guangjun Nie* and Zijian Li*. No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart. Toxicology letter. 2013, 222:197–203. 22Jimin Wu，Zijian Li* .Biomedical Applications of Nanotechnology. Chinese Science Bulletin 2013 Vol. 58 (35): 4515-4518. 23 Zong-shi Li, Yao-Song, Rui Xing, Hai-yi Yu, You-yi Zhang, Zi-jian Li*, Wei Gao*. Heat shock protein 70 acts as a potential biomarker for early diagnosis of heart failure. PLOS ONE. 2013, (8) 7: e67964. 24邢瑞，杨承志，吴济民，鲁海燕，吕志珍，张幼怡，李子健*. HIP-55抑制异丙基肾上腺素诱导的心脏成纤维细胞ROS产生. 中国分子心脏病学杂志，2013,2，424-428.25吴济民, 李子健*. G 蛋白偶联受体及其信号通路—2012 年诺贝尔化学奖工作介绍. 生理科学进展.2013,（44）1:75-81.26杨承志, 李子健*. β-arrestin与β-肾上腺素受体.中国细胞生物学学报 2012, 34(11): 1080–1088.27.Zhu RJ, Wu MQ, Li ZJ, Zhang Y, Liu KY. Hematopoietic recovery following chemotherapy is improved by BADGE-induced inhibition of adipogenesis. Int J Hematol. 2013;97(1):58-72.28Xueyan Wang, Xue Meng, Weijing Pei, Zijian Li, Youyi Zhang, * Jianbin Zheng and Xiaohui Zheng*. Construction of adrenergic receptor subtype affinity chromatographic models for detection of ligand–receptor interactions. Analytical Methods. Anal. Methods, 2012, 4, 3420–3424.29MA Ding, ZHANG You-yi, GUO Yan-li, LI Zi-jian* and GENG Li*. Profiling of microRNA-mRNA reveals roles of microRNAs in cervical cancer. Chinese Medical Journal, 2012, 125（23）:4270-4276. 30Zhao X, Li Q, Bian L, Zheng X, Zheng J, Zhang Y, Li Z. Using immobilized G-protein coupled receptors to screen bioactive traditional Chinese medicine compounds with multiple targets. J Pharm Biomed Anal. 2012;70:549-52. 31Chen C, Du J, Feng W, Song Y, Lu Z, Xu M, Li Z, Zhang Y. β-adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCδ/p38 MAPK signaling in neonatal mouse cardiac fibroblasts. Br J Pharmacol. 2012; 166(2):676-88. IF: 4.40932高炜，李子健. 高密度脂蛋白胆固醇与动脉粥样硬化——高密度脂蛋白胆固醇是“好”胆固醇？中国医学前沿杂志2011 ;3 ( 5 ):1-3.33陈嵘，耿力，杨京京，张幼怡，李子健. RhoC、ROCKⅠ在宫颈癌前病变和宫颈癌中的表达及意义. 肿瘤预防与治疗. 2011,24(03): 141-144. 34Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lü Z, Li Z, Zhang Y. Transactivated EGFR mediates {alpha}1-AR-induced STAT3 activation and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2011;301(5):H1941-51. 35He K, Fu Y, Zhang W, Yuan J, Li Z, Lv Z, Zhang Y, Fang X. Single-molecule imaging revealed enhanced dimerization of transforming growth factor β type II receptors in hypertrophic cardiomyocytes. Biochem Biophys Res Commun. 2011;407(2):313-7.)36Ma X, Song Y, Chen C, Fu Y, Shen Q, Li Z, Zhang Y. Distinct actions of intermittent and sustained β-adrenoceptor stimulation on cardiac remodeling. Sci China Life Sci. 2011;54(6):493-501. 37Ning Liu, Kai-zheng Gong, Yuan –bin Cai, Zi-jian Li*. Identification of proteins in response to adrenergic receptor subtype-specific hypertrophy in cardiomyocytes by proteomic approaches. Biochemistry (Moscow), 2011,76(10):1140-1146 38Zi-jian Li, Ning Liu, Qi-de Han and You-yi Zhang. A Proteome Reference Map and Regulation Network of the Neonatal Rat Cardiomyocyte. Acta Pharmacologica Sinica, 2011; 32(9):1116-27. 39Xinye Xu, Zijian Li, and Wei Gao. Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside. Biomarkers, 2011;16(6):466-75. 40Fengjin Qin, Yao Song, Zijian Li, Ling Zhao, Youyi Zhang, Li Geng. S100A8/A9 Induces Apoptosis and Inhibits Metastasis of CasKi Human Cervical Cancer Cells. Pathol. Oncol. Res. 2010; 16:353–36041Shala L. Thomasa, Jing Zhao, Zijian Li, Bin Lou, Yuhong Du, Jamie Purcell, James P. Snyder, Fadlo R. Khuri, Dennis Liotta, and Haian Fu. Activation of the p38- pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochemical Pharmacology. 2010，80(9):1309-1316.42Zijian Li, Ning Liu, Li-Shu zhang, Kaizheng Gong, Yuanbin Cai, Wei Gao, Zhiqiang Liu, Shuying Liu, Qide Han and Youyi Zhang. Proteomic profiling reveals comprehensive insights into adrenergic receptor-mediated hypertrophy in neonatal rat cardiomyocytes. Proteomics Clin. Appl. 2009, 3, 1407–1421. 43Yuhong Du, Zijian Li, Lian Li, Zhuo (Georgia) Chen, Shi-Yong Sun, Peifang Chen, Dong M. Shin, Fadlo R. Khui, and Haian Fu. Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells. Journal of Receptors and Signal Transduction, 2009, 29（3-4）182-194. 44Xinfeng Zhao, Xiaohui Zheng, Yinmao Wei, Liujiao Bian, Shixiang Wang, Jianbin Zheng, Youyi Zhang, Zijian Li, Weijin Zang. Corrigendum to “Thermodynamic study of the interaction between terbutaline and salbutamol with an immobilized ?2-adrenoceptor by high-performance liquid chromatography”. Journal of chromatography B, 2009, 877: 911-918. 译著1. 译者 《心力衰竭》(第2版Braunwald心脏病学姊妹卷). (美)曼恩. 主译: 高炜,张幼怡. 北京大学医学出版社, 2013.2. 译者 蛋白质－蛋白质相互作用 方法与应用. 原著：（美）傅海安（Haian Fu）， 张幼怡　主译， 韩启德 主审， 出版社：北京大学医学出版社 2008-103. 副主译 受体信号转导研究方法（第2版）. 原著：（英）维拉斯（Willars，G.B.）， （英）查理斯（Challiss，R.A.J），张幼怡　主译， 韩启德 主审， 出版社：北京大学医学出版社2008-03
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