任爱国
任爱国 教授、博士生导师
renag@pku.edu.cn
北京市海淀区学院路38号
北京大学


个人简介
中国妇幼保健协会出生缺陷防治与分子遗传分会主任委员，中国妇幼保健协会常务理事，残疾人事业发展研究会常务理事；中国肢残人协会脊柱裂与脑积水委员会顾问，Teratology Society会员，Biomedical and Environmental Sciences编委，主持制定“围受孕期增补叶酸预防神经管缺陷指南(2017)”，获教育部自然科学奖一等奖一项。



主要研究方向
环境污染与出生缺陷
营养与出生缺陷
表观遗传与出生缺陷
遗传变异与出生缺陷

代表性科研项目
1.任爱国. 环境因素导致重要器官发育异常的关键环节. 科技部; 2016-2021.
2.任爱国. 多环芳烃致胎儿神经管缺陷作用及氧化应激机制研究. 国家自然科学基金委员会; 2014-2017.
3.任爱国. 多环芳烃致小鼠神经管缺陷过程中细胞凋亡的作用及诱导机制. 中华人民共和国教育部; 2013-2016.
4.任爱国(Co-PI). Study of Neural Tube Defects Etiology: Genome and Exposome. National Institute of Health, NIH, USA; 2012-2016.
5.任爱国. 多环芳烃及其代谢酶基因多态性与胎儿神经管畸形发生危险性之间的关系. 国家自然科学基金委员会; 2011-2013.
6.任爱国. 出生缺陷高发区的病因和综合防治措施的研究, 科技部; 2002-2004.

10篇代表性论文
1.Huang Y, Ren A, Wang L, Jin L, Lin S, Li Z, et al. Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Clin Epigenetics. 2019;11(1):72.
2.Pi X, Wei Y, Li Z, Jin L, Liu J, Zhang Y, et al. Higher concentration of selenium in placental tissues is associated with reduced risk for orofacial clefts. Clin Nutr. 2019.
3.Lin S, Ren A, Wang L, Santos C, Huang Y, Jin L, et al. Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons. Clin Epigenetics. 2019;11(1):13.
4.Pi X, Jin L, Li Z, Liu J, Zhang Y, Wang L, et al. Association between concentrations of barium and aluminum in placental tissues and risk for orofacial clefts. Sci Total Environ. 2019;652:406-12.
5.Lin S, Ren A, Wang L, Huang Y, Wang Y, Wang C, et al. Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects. Free Radical Biology and Medicine. 2018;116:149-58.
6.Wang L, Lin S, Zhang J, Tian T, Jin L, Ren A. Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis. Epigenetics. 2017;12(2):157-65.
7.Jin L, Liu J, Ye B, Ren A. Concentrations of selected heavy metals in maternal blood and associated factors in rural areas in Shanxi Province, China. Environment International. 2014;66(0):157-64.
8.Wang L, Li Z, Jin L, Li K, Yuan Y, Fu Y, et al. Indoor air pollution and neural tube defects: effect modification by maternal genes. Epidemiology. 2014;25(5):658-65.
9.Ren A, Qiu X, Jin L, Ma J, Li Z, Zhang L, et al. Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(31):12770-5.
10.Li Z, Zhang L, Ye R, Pei L, Liu J, Zheng X, et al. Indoor air pollution from coal combustion and the risk of neural tube defects in a rural population in Shanxi Province, China. American Journal of Epidemiology. 2011;174(4):451-8.