北京大学药学院导师教师师资介绍简介-林文翰

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林文翰教授

科技部863计划首席科学家

北京大学海洋研究院副院长

北京大学药学院教授

天然药物及仿生药物国家重点实验室博士生导师

E-mail: whlin@bjmu.edu.cn

1978-1982 温州大学化学专业毕业

1985-1990 中国科学院上海药物所天然药物专业获硕士和博士学位

1991-1992 北京医科大学药学院博士后

1993-1996 北京医科大学药学院副教授

1996-至今北京大学药学院教授

1993-1994 巴西Sao Paulo大学化学研究所和Rio de Janeiro大学访问学者

1995-1996 日本东邦大学药学部海外特别研究员

1999-2000 德国Wurzburg大学和Duesseldorf大学客座教授

2019-至今北京大学海洋研究院副院长

长期从事海洋生物天然产物结构与生物活性关系，海洋药物先导化合物发现等研究。先后承担国家科技部973和863项目、国家重大新药创制课题、科技部国际合作课题、国家自然基金重点课题等国家级课题。在国际SCI学术期刊发表文章200余篇；获新药证书1项；新药临床批件1项；出版专著3部；曾获中国药学会科学技术奖一等奖，卫生部吴阶平-保罗杨森医学药学奖，国家科技进步二等奖，中国青年化学家奖等。兼任中国药学会海洋药物专业委员会主任委员，中国药学会常务理事，中国海洋学会理事，国家药品监督局新药审评委员。担任"中国海洋药物杂志"副主编，"中国天然药物"，"药物化学"，"中国药学(英文版)"，"国际药学杂志"等核心期刊编委，"Journal of Asian Natural Product Research"，"Chemistry Biodiversity"杂志编委。

林文翰教授

科技部863计划首席科学家

Tel: 010-*******

E-mail: whlin@bjmu.edu.cn

研究兴趣

对我国东南沿海生物资源调查的基础上，对100余种海洋动植物和内生菌进行与人类重大疾病相关的生物活性评价的基础上，进行了系统的代谢产物结构多样性研究，应用现代色谱和波谱学技术,确定3500多种海洋天然产物的化学结构，其中400余种为国际上首次发现的新颖结构化合物，多种为全新骨架化合物，海洋天然产物的结构类型包括生物碱类，萜类，聚醚类以及其它特殊的结构类型，为进一步的药物筛选提供了丰富的海洋天然化合物资源。建立了海洋天然产物的信息库和样品库，为我国海洋生物药用资源的系统化管理提供了平台。对我国南海海洋底栖无脊椎动物的化学生态学开展了研究，阐明同种不同海域和相同海域不同物种之间的代谢信息分子及其功能；宿主生物与内生菌的代谢调控及其相互关系。

课题组在研项目

1. 科技部“973”重大研究计划：超深渊生物独特分子的发现和功能潜力研究（2015CB755900，2015-2019）

2. 国家自然科学基金课题：西松烷二萜等特征产物介导Sinularia属软珊瑚化学生态功能及其作用机理研究（41376127，2014-2017）

3. 教育部博士点重点基金：软珊瑚Sinularia属特征产物介导生物抗污等生态功能及其作用机理研究（20130001130009，2014-2017）

4. 国家海洋局国际合作重大项目：深海微生物生态学-据阿秀介导生物竞争与沉默基因挖掘（2015-2018）

5. 国家自然科学基金-山东联合基金：海洋先导化合物的发现（U1406402-1, 2014-2016）

6. 国家自然科学基金国际合作项目：海洋抗肿瘤二萜的靶向作用机理与代谢途径研究（NSFC-DFG, GZ816, 2013-2016）

7. 国家海洋公益专项：海洋微生物小分子化合物制备与结构研究（2010319123366025-4, , 2013-2015)。

8. 国家海洋局大洋计划专项课题：深海微生物样品库构建与生物功能评价（DY125-15-T-01， 2013-2015)

9. 科技部863计划课题：远海大型生物全新天然产物的发现与药物先导化合物的优化（2013AA092902， 2013-2015）

10. 国家自然科学基金重点项目:海绵 baculiferin型新生物碱探针对HIV-1 Vif和APOBEC3G 的调控和作用机理研究（30930109, 2011-2014)

荣誉奖励

1.中国药学会科学和技术奖一等奖

2.卫生部吴阶平-保罗杨森医学药学奖

3.国家科技进步二等奖

4.中国青年化学家奖

5.中科院院长奖

海洋生物相关代表性论文

1
Xueqing Chen, Longlong Si, Dong Liu, Peter Proksch, Lihe Zhang, Demin Zhou,* Wenhan Lin*. Neoechinulin B and its analogues as potential entry inhibitors

of influenza viruses, targeting viral hemagglutinin. Eur. J. Med. Chem. 2015, 93, 182-195.

2
Dong Liu, Hong Lin, Peter Proksch, Xixiang Tang, Zhongze Shao,, and Wenhan Lin* Microbacterins A and B, unusual peptaibols from the deep-sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T). Org. Lett. 2015, 17 (5), 1220-1223.

3
Yang Zhao, Longlong Si, Dong Liu, Peter Proksch, Demin Zhou, Wenhan Lin*. “Truncateols AN, new isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with anti-H1N1 virus activities”. Tetrahedron 2015, 71, 2708-2718

4
Siwen Niu，Dong Liu, Peter Proksch, Zongze Shao, Wenhan Lin* New polyphenols from a deep sea Spiromastix sp. fungus, and their antibacterial activities.

Mar. Drugs 2015, 13(4), 2526-2540.

5
Yi Yang, Yang Zhang, Dong Liu, Min Li-Weber, Bing Shao*, Wenhan Lin*. Dolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor

activities. Fitotherpia 2015, 103, 277-282.

6
Jennifer Neumann, Yi Yang, Rebecca Köhler, Marco Giaisi, Mathias Witzens-Harig, Dong Liu, Peter H. Krammer, Wenhan Lin and Min Li-Weber “Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR–Chk1/Chk2-regulated

cell cycle arrest”，Inter. J. Cancer 2015, 137, 2739–2748.

7
Qi Wu,† Chongming Wu,‡ Hailin Long,† Ran Chen,‡ Dong Liu,† Peter Proksch,§ Peng Guo,‡,* Wenhan Lin*, “Varioxiranols A-G and 19-O-Methyl-22-methoxypre-shamixanthone, PKS and Hybrid PKS-Derived Metabolites from a Sponge Associated Emericella variecolor Fungus”,

J. Nat. Prod. 2015, 10.1021/acs.jnatprod.5b00578.

8
Yong Li, Chongming Wu, Dong Liu, Peter Proksch, Peng Guo, Wenhan Lin* “Chartarlactams A−P, phenylspirodrimanes from a sponge-associated fungus Stachybotrys chartarum with anti-hyperlipidemic activities” J. Nat. Prod. 2014, 77, 138-147.

Siwen Niu, Dong Liu, Xinxin Hu, Peter Proksch, Zhongzhe Shao, Wenhan Lin “Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea derived Spiromastix sp. fungus” J. Nat. Prod. 2014, 77, 1021-1030.

10
Yao Wang, Xixiang Tang, Zhongzhe Shao, Jinwei Ren, Dong Liu, Peter Proksch, Wenhan Lin* “Indole based alkaloids from deep-sea bacterium Shewanella

piezotolerans with antitumor activities” J. Antibiotics 2014, 67, 395-399.

11
Wei Cheng, Dong Liu, Fengying Zhang, Qingying Zhang, Patchara Pedpradab, Peter Proksch, Hong Liang, Wenhan Lin* “Formamidobisabolene-based derivatives from a sponge Axinyssa sp.” Tetrahedron, 2014, 70, 3576-3583.

12
Dawei Chen, Wei Cheng, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin* . “Capillosananes SZ, new sesquiterpenoids from the soft coral Sinularia

capillosa Tetra. Lett. 2014, 55, 3077-3082.

13
Zehong Wu, Dong Liu, Peter Proksch, Peng Guo,Wenhan Lin* Punctaporonins H: caryophyllene-type sesquiterpenoids from the sponge-associated fungus

Hansfordia sinuosae. Mar. Drugs 2014, 12(7), 3904-3916.

14
Yong Li, Dong Liu, Shan Cen, Peter Proksch, and Wenhan Lin*. Isoindolinone-type alkaloids from the sponge derived fungus Stachybotrys chartarum”,

Tetrahedron, 2014, 70, 7010-7015.

15
Dong Liu, Aigang Yang, Chongming Wu, Peng Guo, Peter Proksch, Wenhan Lin*. Lipid lowering effects of farnesylquinone and related analogues from the

marine-derived Streptomyces nitrosporeus. Bioorg. Med. Chem. Lett. 2014, 24, 5288-5293.

16
Zhen Liu, Wei Cheng, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin*. Capnosane-type cembranoids from the soft coral Sarcophyton

trocheliophorum with antibacterial effects. Tetrahedron 2014, 70, 8703-8713.

17
Jian Bai, Dong Liu, Siwang Yu, Peter Proksch, Wenhan Lin*.Amicoumacins from the marinederived bacterium Bacillus sp. with the inhibition of NO

production. Tetra. Lett. 2014. 55, 6286-6291.

18
Jinwei Ren, Dong Liu, Li Tian, Yangye Wei, Peter Proksch, Jinzhang Zeng, Wenhan Lin *， “Venezuelines A–G, new phenoxazine-based alkaloids and

aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77” Bioorg. Med. Chem. Lett. 2013, 23, 301–304.

19
Daowan Lai, Zhufeng Geng, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, and Wenhan Lin*, “Cembranoids from the soft coral Sinularia rigida with

antifouling activities” J. Agric. Food Chem. 2013, 61, 4585−4592.

20
Jinwei Ren, Yi Yang, Dong Liu, Wei Chen, Peter Proksch, Bing Shao, Wenhan Lin* “Sequential determination of new peptaibols asperelines GZ12 produced

by marine derived fungus Trichoderma asperellum using ultrahigh pressure liquid chromatography combined with electrosprayionization tandem mass

spectrometry” J. Chromatogr. A, 2013, 1309, 90– 95.

21
Zhifang Xi, Wei Bie, Wei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch,Wenhan Lin * “ Sarcophyolides BE, New Cembranoids from the Soft Coral

Sarcophyton elegans” Mar. Drugs 2013, 11, 3186-3196.

22
Dawei Chen, Wei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch, and Wenhan Lin*, “ AsteriscaneType Sesquiterpenoids from the Soft Coral Sinularia

capillosa” J. Nat. Prod. 2013, 76, 1753−1763.

23
Aigang Yang, Longlong Si, Zhenping Shi, Li Tian, Dong Liu, Demin Zhou, Peter Proksch, Wenhan Lin* “Nitrosporeusines A and B, unprecedented thioester-

bearing alkaloids from the Arctic Streptomyces nitrosporeus” Org. Lett. 2013, 15, 5366-5369.

24
Zhifang Xi, Wei Bie, Wei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch and Wenhan Lin* “Sarcophytolides GL, New Biscembranoids from theSoft coral

Sarcophyton elegans” Helv.Chim. Acta 2013, 96，2218-2227.

25
Mona, E.N; Weaam, E.; Lin, W.H.; Gedara, S.; Badria, F.; Saad, H.E.A.; Lai, D.; Proksch, P. “Alkaloids and polyketides from Penicillium citrinum,an

endophyte isolated from the Moroccan plant Ceratonia siliqua” J. Nat. Prod. 2013, online.

26
Pham, C.; Weber, H.; Hartmann, R.; Wray, V.; Lin, W.H.; Lai, D.; Proksch, P. “New cytotoxic 1,2,4thiadiazole alkaloids from the ascidian Polycarpa aurata”

Org. Lett. 2013, 15. 2230-2233.

27
Wang, J.; Lin, W.H.; Wray, V.; Lai, D.; Proksch, P. “Induced production of depsipeptides by coculturing Fusarium tricinctum and Fusarium begonia”

Tetrahedron Lett. 2013, 54, 2492-2496.

28
Bara, R.; Zerfass, I.; Aly, A.H.; GoldbachGecke, H.; Raghavan, V.; Sass, P.; Mandi, A.; Wray, V.; Polavarapu, P.L.; Pretsch, A.; Lin, W.H.; Proksch, P.

Atropisomeric dihydroanthracenones as inhibitors of multiresistant Staphylococcus aureus” J. Med. Chem. 2013, 56, 3257-3272.

29
Ebrahim, W.; Aly, A.H.; Mandi, A.; Wray, V.; Essassi, El M.; Ouchbani, T.; Bouhfid, R.; Lin, W.H.; Proksch, P.; Kurtan, T. “OHeterocyclic embeurekols from

embellisia eureka, an endophyte of Cladanthus arabicus” Chirality 2013, 25, 250-256.

30
Ebrahim, W.; Aly, A.H.; Wray, V.r; Mandi, A.; Teiten, M.; Gaascht, F.; Orlikova, B.; Kassack, M.U.; Lin, W.H.; Diederich, M.; Proksch, P. “Embellicines A

and B:absolute configuration and NF-κB transcriptional inhibitory activity” J. Med. Chem. 2013, 56, 2991-2999

31
Niemann, H.; Lin, W.H.; Mueller, W.E.G.; Kobbutat, M.; Lai, D.; Proksch, P. “Trimeric hemibastadin congener from the marine sponge Ianthella basta” J. Nat.

Prod. 2013, 76, 121-125.

32
Zhou, Y.; Debbab, A.; Mandi, A.; Wray, V.; Schulz, B.; Mueller, W.E.G.; Kassack, M.; Lin, W.H.; Kurtan, T.; Proksch, P.“Alkaloids from the sponge-associated

fungus Aspergillus sp.” Eur. J. Org. Chem. 2013, 2013, 894-906.

33
Yongxin Li, Shangjian Yu, Dong Liu, Peter Proksch, Wenhan Lin* “inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria

agallocha L.” Bioorg. Med. Chem. Lett. 2012, 22, 1099-1102.

34
Jin Li, Huajie Zhu, Jinwei Ren, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, Wenhan Lin*, “Globostelletins JS, isomalabaricanes with unusual cyclopentane

sidechains from the marine sponge Rhabdastrella globostellata”, Tetrahedron, 2012, 68, 559-565.

35
Dawei Chen, Shanjiang Yu, Leen van Ofwegen, Peter Proksch, and Wenhan Lin*, “Anthogorgienes A−O, New Guaiazulene Derived Terpenoids from a 2

Chinese Gorgonian Anthogorgia Species, and Their Antifouling and Antibiotic Activities”, J. Agr. Food Chem. 2012, 60, 112-123.

36
Haiyan Shi, Shanjiang Yu, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin*, “Sinularones AI, new cyclopentenone and butenolide derivatives from a

marine soft coral Sinularia sp. and their antifouling activity”. Marine Drugs, 2012, 10, 1331-1344.

37
Dawei, Chen; Dong, Liu, Shi, Shen; Wei Cheng; Wenhan Lin* “Terpenoids from a Chinese gorgonian Anthogorgia sp. and their antifouling activities” Chin. J.

Chem. 2012, 30, 1459—1463.

38
Shi Shen, Huajie Zhu, Dawei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin*, “ Pavidolides AE, new cembranoids from the soft coral

Sinularia pavida, Tetrahedron Lett.” 2012, 53, 5759–5762.

39
Daowan Lai, Dong Liu, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin*, “Antifouling eunicellintype diterpenoids from the gorgonian

Astrogorgia sp.” J. Nat. Prod. 2012. 75, 1595−1602.

40
Lena Hammerschmidt, Victor Wray, WenHan Lin, Elena Kamilova, Peter Proksch, Amal H. Aly “New styrylpyrones from the fungal endophyte Penicillium

glabrum isolated from Punica granatum” Phytochemistry Letters 2012, 6, 125-128.

Yongxin Li, Ying Xu, Lingli Liu, Zhuang Han, Pok Yui Lai, Xiangrong Guo ,Xixiang Zhang, Wenhan Lin* PeiYuan Qian “Five new amicoumacins isolated

from a marine-derived Bacterium Bacillus subtilis” Mar. Drugs 2012, 10, 319-328.

42
Shi Shen, Dong Liu, Chen Wei, Peter Proksch, Wenhan Lin* “Purpuroines AJ, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic

activity and regulation of tyrosine kinases”, Bioorg. Med. Chem. Lett. 2012, 20，6924–6928.

43
Wei Jiang, Dong Liu, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, Wenhan Lin*, “Brominated polyunsaturated lipids and their stereochemistry from the

Chinese marine sponge Xestospongia testudinaria” Tetrahedron 2011, 67, 58-68.

Daowan Lai, Yongxin Li, Minjuan Xu, Zhiwei Deng, Leen van Ofwegen, Peiyuan Qian, Peter Proksch, Wenhan Lin* “Sinulariols AeS, 19oxygenated

cembranoids from the Chinese soft coral Sinularia rigida” Tetrahedron 2011, 67, 6018-6029.

45
Dong Liu, Jing Xu, Wei Jiang, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch,Wenhan Lin* “Xestospongienols AL, brominated acetylenic acids from the

Chinese marine sponge Xestospongia testudinaria” Helv. Chim. Acta 2011, 94, 1600-1607.

46
Pengcheng Yan, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin* “Lobophytones UZ1, biscembranoids from the Chinese soft coral Lobophytum

pauciflorum”, Chem. Biodiver. 2011, 8, 1724-1734.

47
Daowan Lai, Shanjiang Yu, Leen van Ofwegen, Frank Totzke, Peter Proksch, Wenhan Lin* “9,10Secosteroids, protein kinase inhibitors from the Chinese

gorgonian Astrogorgia sp.” Bioorg. Med. Chem. 2011, 19, 6873-6880.

Xiu E. Feng, Wan Yi Zhao, Shu Rong Ban, Cheng Xiao Zhao, Qing Shan Li,Wen Han Lin* “StructureActivity Relationship of Halophenols as a New Class of

Protein Tyrosine Kinase Inhibitors” Int. J. Mol. Sci. 2011, 12, 6104-6115.

49
HongBing Liu, RuAngelie EdradaEbel, Rainer Ebel, Yao Wang, Barbara Schulz, Siegfried Draeger, Werner E. G. Muller, Victor Wray, WenHan Lin*, Peter

Proksch* “Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus.”. Helvetica Chimica Acta 2011, 94, 623-631.

50
Sherif S. Ebada, Barbara Schulz, Victor Wray, Frank Totzke, Michael H. G. Kubbutat, Werner E. G. Müller, Alexandra Hamacher, Matthias U. Kassack,

Wenhan Lin, Peter Proksch. “Arthrinins AD: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.” Bioorg. Med. Chem.

2011, 19, 4644–4651.

51
Zhou, Yaming; Mandi, Attila; Debbab, Abdessamad; Wray, Victor; Schulz, Barbara; Mueller, Werner E. G.; Lin, Wenhan; Proksch, Peter; Kurtan, Tibor; Aly,

Amal H. “New austalides from the sponge-associated fungus Aspergillus sp.” European J. Org. Chem. 2011, 6009-6019.

52
Bayer, Mirko; Hellio, Claire; Marechal, JeanPhilippe; Frank, Walter; Lin, Wenhan; Proksch, Peter. „Antifouling bastadin congeners target mussel phenoloxidase

and complex copper(II) ions.” Marine Biotechnology 2011, 13, 1148-1158.

53
Ding, Ling; Maier, Armin; Fiebig, Heinz-Herbert; Lin, WenHan; Hertweck, Christian. “A family of multicyclic indolosesquiterpenes from a bacterial endophyte.”

Org. Biomol. Chem. 2011, 9, 4029-4031.

54
Ding, Ling; Maier, Armin; Fiebig, HeinzHerbert; Goerls, Helmar; Lin, WenHan; Peschel, Gundela; Hertweck, Christian. “Divergolides AD from a mangrove

endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis.” Angewandte Chemie, 2011, 50, 1630-1634

55 Cui Shi, Min-Juan Xu, Mirko Bayer, Zhi-Wei Deng, Michael H.G. Kubbutat, Wim Waejen,Peter Proksch, Wen-Han Lin, “Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa”, Phytochemistry 2010, 71, 435–442.
56
Yan Pengcheng, Yang Lv, Leen van Ofwegen, Peter Proksch, Wenhan Lin* “lobophytones AG, new isobiscembranoids from the soft coral Lobophytum

pauciflorum” Org. Lett. 2010, 12, 2484-2487.

57
Jin Li, Bo Xu, Jinrong Cui, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, Wenhan Lin* Globostelletins AI, cytotoxic isomalabaricane derivatives from the

marine sponge Rhabdastrella globostellata” Bioorg. Med. Chem. 2010, 18, 4639-4647.

58
Guotao Fan, Zelin Li, Shi Shen, Yi Zeng, Yishu Yang, Minjuang Xu, Torsten Bruhn, Heike Bruhn, Joachim Morschhser, Gerhard Bringmann, Wenhan Lin „

Baculiferins A–O, O-sulfated pyrrole alkaloids with anti-HIV1 activity, from the Chinese marine sponge Iotrochota baculifera”,Bioorg. Med. Chem. 2010,18,

5466–5474.

59
Yongxin Li, Jun Liu, Shanjiang Yu, Peter Proksch, Jun Gu, Wenhan Lin*, “TNFa Inhibitory Diterpenoids from the Chinese Mangrove Plant Excoecaria

agallocha L.” Phytochemistry, 2010, 71,2124-2131.

60
Pengcheng Yan, Zhiwei Ddeng, Leen van Ofwegen, Peter proksch, Wenhan Lin*, “Lobophytones HN, Biscembranoids from the Chinese Soft Coral Lobophytum

pauciflorum”，Chem. Pharm. Bull. 2010，58(12) 1591—1595.

61
Pengcheng Yan, Zhiwei Deng, Leen van Ofwegen, Peter Proksch and Wenhan Lin* “Lobophytones O, new biscembranoids and cembranoid from soft coral

Lobophytum pauciflorum. Mar. Drugs 2010, 8(11), 2837-2848.

62
Abdessamad Debbab,1 Amal H. Aly,1 Wen H. Lin2 and Peter Proksch “Bioactive compounds from marine bacteria and fungi” Microbial Biotechnology 2010, 3,

544–563.

63
Ding, Ling; Muench, Jan; Goerls, Helmar; Maier, Armin; Fiebig, Heinz-Herbert; Lin, WenHan; Hertweck, Christian. “Xiamycin, a pentacyclic

indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte”. Bioorg. Med. Chem. Lett. 2010, 20,

64
Jianxin Cui, Zhiwei Deng, Minjuan Xu, Peter Proksch, Qingshan Li, Wenhan Lin* „Protolimonoids and Limonoids from the Chinese Mangrove Plant Xylocarpus

granatum” Helv. Chim. Acta. 2009, 92, 139-150.

65
Ren, Jinwei; Xue, Chunmei; Tian, Li; Xu, Minjuan; Chen, Jian; Deng, Zhiwei; Proksch, Peter; Lin, Wenhan, Asperelines A-F, peptaibols from the marine-

derived fungus Trichoderma asperellum. Journal of Natural Products (2009), 72(6), 1036-1044.

66
Liu, Dong; Xu, Min-Juang; Wu, Li-Jun; Deng, Zhi-Wei; Lin, WenHan. “Norisoprenoids from the marine sponge Spheciospongia sp.” J. Asian Nat. Prod. Res.

2009, 11, 811-816.

67 Xue, Chun-Mei; Tian, Li; Lin, Wen-Han; Deng, Zhi-Wei. “Anthraquinone derivatives from Micromonospora rhodorangea.” Nat. Prod. Res. 2009, 23, 533-538.
68
Debbab, Abdessamad; Aly, Amal H.; EdradaEbel, RuAngelie; Wray, Victor; Mueller, Werner E. G.; Totzke, Frank; Zirrgiebel, Ute; Schaechtele, Christoph;

Kubbutat, Michael H. G.; Lin, Wen Han; Mosaddak, Mahjouba; Hakiki, Abdelhak; Proksch, Peter; Ebel, Rainer. “Bioactive Metabolites from the Endophytic

Fungus Stemphylium globuliferum Isolated from Mentha pulegium” J. Nat. Prod. 2009, 72, 626-631.

69
Liya Li, Isabel Sattler, Zhiwei Deng, Ingrid Groth, Grit Walther, Klaus-Dieter-Menzel, Gudrun Peschel, Susanne Grabley, Wenhan Lin*，“A-seco-oleane-type

triterpenes from Phomopsis sp. (strain HKI0458) isolated from the mangrove plant Hibiscus tiliaceus”，Phytochemistry, 2008, 69， 511-517.

70
Xingping Huang, Zhiwei Deng, Rob W.M. van Soest, Wenhan Lin* “Brominated derivatives from the Chinese sponge Pseudoceratina sp.” J. Asian Nat. Prod.

Res. 2008, 10, 239-242.. 71. Li Han, Xueshi Huang, H.M. Dahse, Ute Moellmann, Susanne Grabley,Wenhan Lin*, “new abietane diterpenoids from the

mangrove Avicennia marina” Planta Medica, 2008, 74, 432-437.

71
Li Han, Xueshi Huang, H.M. Dahse, Ute Moellmann, Susanne Grabley, Wenhan Lin*, “new abietane diterpenoids from the mangrove Avicennia marina”Planta

Medica, 2008, 74, 432-437.

72
Aobo Guo, Li Jin, Zhiwei Deng, Shaoqing Cai, Shunxin Guo, Wenhan Lin “new stemona alkaloids from the roots of Stemona sessilifolia” Chemistry.

Biodiversity,2008, 5, 598-605.

73
Yu Sun, Jie Ouyang, Zhiwei Deng, Qingshan Li, Wenhan Lin*, “Structure elucidation of five new iridoid glucosides from the leaves of Avicenniamarina”,

Magn. Reson. Chem. 2008, 46, 638–642.

74
Aiying Ma, Zhiwei Deng, Leen van Ofwegen, Mirko Bayer, Peter Proksch, Wenhan Lin* “Dendronpholides AR, Cembranoid Diterpenes from the Chinese Soft

Coral Dendronephthya sp.”, J. Nat. Prod. 2008, 71, 1152–1160.

75
Ke Ma, Yi Yang, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, and Wenhan Lin* “Two new bromotyrosine derivatives from the marine sponge

Pseudoceratina sp” Chemistry and Biodiversity, 2008, 5, 1313-1320.

76
Jianxin Cui, Jie Ouyang, Zhiwei Deng, Wenhan Lin*, “structure elucidation of an unprecedented alkaloid and a new limonoid from Xylocarpus granatum”,

Magn. Reson. Chem. 2008, 46, 894-897.

77
Yan Qiu, Zhi Wei Deng, and Wen Han Lin*, “New Anor steroids and their antifouling activity from the Chinese Marine Sponge Acanthella cavernosa”, Steroids,

2008, 73, 1500-1504.

78
Fang Lv, Minjuan Xu, Zhiwei Deng, Nicole J. de Voogd, Rob W.M. van Soest, Peter Proksch, and Wenhan Lin*“Rhabdastrellins AF, Isomalabaricane

Triterpenes from the Marine Sponge Rhabdastrella aff. Distincta”，J. Nat. Prod. 2008, 71，1738-1741.

79
Li-Ya Li; Yi Ding; Ingrid Groth; Klaus-Dieter Menzel; Gundela Peschel; Kerstin Voigt; Zi-Wei Deng; Isabel Sattler; WenHan Lin, “Pyrrole and indole

alkaloids from an endophytic Fusarium incarnatum (HKI00504) isolated from the mangrove plant Aegiceras corniculatum” J. Asian Nat. Prod. Res. 2008, 10,

765-770.

80
Xue, Chunmei; Tian, Li; Xu, Minjuan; Deng, Zhiwei; Lin, Wenhan. “A new 24membered lactone and a new polyene lactone from the marine bacterium Bacillus

marinus.” J. Antibio. 2008, 61, 668-674.

81
Aly, A. H.; EdradaEbel, R.; Indrni, I. D.; Wray, V.; Müller, W. E. G.; Totzke, F.; Zirrgiebel, U.; Schächtele, C.; Kubbutat, M. H. G.; Lin, W. H.; Proksch, P.;

Ebel, R., “Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense”. J. Nat.

Prod., 2008, 71, 972-980.

82
Xiang Li, Isabel Sattler, Wenhan Lin*, “penisporolides A and B, two new spiral lactones from the marine-derived fungus Penicillium sp.” J. Antibiotics,2007,60,

191-195.

83
Xinping Huang, Min Li, Bo Xu, Xiaobin Zhu, Zhiwei Deng, Wenhan Lin*,“ Proteasome and NFkB inhibiting phaeophytins from the green alga Cladophora

fascicularis” Molecules, 2007, 12, 582-592.

84
Mingjuan Xu, Guido Gessner, Ingrid Groth, Corinna Lange, Arnulf Christner, Torsten Bruhn, Zhiwei Deng, Xiang Li, Stefan Heinemann, Susanne Grabley,

Gerhard Bringmann, Isabel Sattler, Wenhan Lin*, “shearinines DK, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking

activity on large-conductance calcium-activated potassium channels”, Tetrahedron, 2007, 63 (2), 435-444.

85
Jianxin Cui, Jun Wu, Zhiwei Deng, Peter Proksch, and Wenhan Lin, „Xylocarpins AI, Limonoids from the Chinese Mangrove Plant Xylocarpus granatum”,

J. Nat. Prod. 2007, 70, 772-778.

86
Li Han, Xueshi Huang, HansMartin Dashe, Ute Moellmann, Hongzheng Fu, Susanne Grabley, Isabel Sattler, Wenhan Lin* “unusual naphthoquinone derivatives

from the twigs of Avicennia marina” J. Nat. Prod. 2007, 70, 923-927.

87
Shengan Tang, Zhiwei Deng, Peter Proksch, and Wenhan Lin*“ Jaspolides G and H, unique bisisomalabaricanes from the Chinese marine sponge Jaspis sp.”,

Tetrahedron Letters, 2007, 48,5443-5447

88
Shuyun bao, Yi ding, Zhiwei Deng, Peter Proksch, Wenhan Lin* “rhyncosides AF, phenolic constituents from the Chinese mangrove plant Bruguiera sexangula

var. rhynchopetala” Chem. Pharm. Bull. 2007, 55, 1175-1180.

89
Han, L.; Huang, X.-S.; Sattler, I.; Fu, H.-Z.; Grabley, S.; Lin, W.H.. “Two new constituents from mangrove Bruguiera gymnorrhiza”.J. Asian Nat. Prod. Res.

2007, 9(4), 327-331.

90
Li, Xiang; Yao, Yanhua; Zheng, Yinan; Sattler, Isabel; Lin, Wenhan. “Cephalosporolides H and I, two novel lactones from a marinederived fungus, Penicillium

sp.” Archives Pharm. Res. 2007, 30, 812-815.

91
Tian, Ran; Ji, Yu-Bin; Liu, Zhen-Ming; Jin, Hong-Wei; Zhang, Liang-Ren; Lin, WenHan. “QSAR and binding mode of a series of combretastatin analogues as

tubulin inhibitors.” Gaodeng Xuexiao Huaxue Xuebao 2007, 28, 2150-2155.

92
Ma, Ke; Li, Wei; Fu, Hongwei; Koike, Kazuo; Lin, Wenhan; van Ofwegen, Leen; Fu, Hongzheng. “New 4methyl steroids from a Chinese soft coral Nephthea

sp.” Steroids 2007, 72, 901-907.

93
Duong, T. N.; Edrada, R.; Ebel, R.; Wray, V.; Frank, W.; Duong, A. T.; Lin, W. H.; Proksch, P. “Putrescine Bisamides from Aglaia gigantean” J. Nat. Prod.

2007, 70, 1640-1643.

94
Tsevegsuren, N.; Edrada, R.; Lin, W.; Ebel, R.; Torre, C.; Ortlepp, S.; Wray, V.; Proksch, P. “Biologically Active Natural Products from Mongolian Medicinal

Plants Scorzonera divaricata and Scorzonera pseudodivaricata” J. Nat. Prod., 2007, 70, 962-967.

95
Xiang Li, Yinan Zheng, Isable Sattler, Wenhan Lin, “Griseusin C, a novel quinine derivative from a marine derived fungus Penicillium sp.” Arch Pharm. Res.

2006, 29, 942-945.

96
Liya Li, Xiang Li, Cui Shi, Zhiwei Deng, Hongzheng Fu, Peter Proksch, Wenhan Lin “Pongamone AE, five flavonoids from the stems of a mangrove plant,

Pongamia pinnata” Phytochemistry, 2006, 67，1347-1352.

97
Liya Li, Xueshi Huang, Isabel Sattler, Hongzheng Fu, Susanne Grabley, Wenhan Lin*, “structure elucidation of a new friedelane triterpene from Hibiscus

tiliaceus”,Mag. Res. Chem. 2006, 44, 624-628.

98
Shengan Tang, Yuehu Pei, Hongzheng Fu, Zhiwei Deng, Jun Li, Peter Proksch, Wenhan Lin, „Jaspolides A-F, six new isomalabricanetype terpenoids from the

sponge Jaspis sp.“ Chem. Pharm. Bull. 2006, 54(1), 4-8.

99
Shanjiang Yu , Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin. “5,8Epidioxysterols and related derivatives from a Chinese Soft Coral Sinularia

flexibilis” Steroids, 2006, 71, 955-959.

100
Xinping Huang, Zhiwei Deng, Xiaobin Zhu, Leen van Ofwegen, Peter Proksch, Wenhan Lin*, ：“krempenes A-D, a series of unprecedented pregnane type

steroids from the marine soft coral Cladiella krempfi”, Helv Chim Acata, 2006, 89, 2020-2026.

101
Shanjiang Yu, Zhiwei Deng, Peter Proksch, Wenhan Lin „Oculatol, Oculatolide, and Anor Sterols from the Sponge Haliclona oculata” J. Nat Prod. 2006,69,

1330-1334.

102
Xue C.; Tian L.; Deng, Z.; Fu H.; Wenhan Lin* ”Janthinolide A-B, two new 2,5 piperazinedione derivatives from endophytic Penicillium janthinellum isolated

from soft coral Dendronephthya sp.”, Die Pharmazia, 2006, 61, 1041-1044.

103
Ashour, M.; Edrada, R.; Ebel, R.; Wray, V.; Watjen, W.; Padmakumar, K.; Muller, W. E. G.; Lin, W. H.; Proksch, P. “Kahalalide Derivatives from the Indian

Sacoglossan Mollusk Elysia grandifolia” J. Nat. Prod. 2006, 69, 1547-1553.

104
Fouad, M.; Edrada, R. A.; Ebel, R.; Wray, V.; Muller, W. E. G.; Lin, W. H.; Proksch, P. “Cytotoxic Isomalabaricane Triterpenes from the Marine Sponge

Rhabdastrella globostellata” J. Nat. Prod., 2006, 69, 211-218.

105
Yan Zhang, Lu Y, Proksch P, Wenhan Lin* “Tagalsins I and J, two novel tetraterpenoids from the mangrove plant, Ceriops tagal”, Org. Lett, 2005, 7, 3037-

3040.

106
Yan Zhang, Lu Y, Deng ZW, Gao T, Proksch P, Wenhan Lin* “Tagalsins A-H, dolabrane type diterpenes from the mangrove plant,Ceriops tagal”,

Phytochemistry, 2005, 66, 1465-1571.

107
Jin PF, Deng ZW, Pei YH, Fu HZ, Li J, Ofwegen L, Proksch P., Wenhan Lin* „Polyhydroxylated steroids from the soft coral Sinularia dissecta“ Steroids,

2005, 70, 487-493.

108
Li GQ, Deng ZW, Guan HS, Ofwegen L, Proksch P., Wenhan Lin* „steroids from the soft coral Dendronephthya sp“ Steroids, 2005, 70, 13-18.

109
Li GQ, Zhang YL, Deng ZW, Ofwegen L, Proksch P., Wenhan Lin* “Cytotoxic cembranoid diterpenes from a soft coral Sinularia gibberosa” J. Nat. Prod.

2005,68, 649-652.

110
Yan Zhang, Lu Y, Deng ZW, Gao T, Proksch P, Wenhan Lin* “Tagalsins A-H, Han L, Huang XS, Sattler I, Moellmann U, Fu HZ, Wenhan Lin*, Grabley S.

“New aromatic compounds from the marine mangrove Bruguiera gymnorrhiza” Planta Medica. 2005, 71, 160-164.

111
Jianxin Cui, Zhiwei Deng , Jun Li, Hongzheng Fu, Peter Proksch, Wenhan Lin* „Phargmalin-type Liomonoids from Mangrove Plant Xylocarpus granatum”,

Phytochemistry, 2005, 66，2334-2339.

112
Minjian Xu, Jingrong Cui, Hongzheng Fu, Peter Proksch, Wenhan Lin, Min Li “embelin derivatives and their anticancer activity through microtubule

disassembly” Planta Medica, 2005, 71, 944-948.

113
Bao S, Deng Z, Fu H, Proksch, Peter, Wenhan Lin*, “diterpenes and disulfides from the marine mangrove plant Bruguiera sexangula var rhynchopetala” Helv

Chim Acata, 2005, 88, 2757-2763.

114
Han Li, Huang X., I. Sattler, Hahse HM, Fu, HZ, Grabley S., Wenhan Lin *“three new pimaren diterpenoids from marine mangrove plant, Bruguiera

gymnorrhiza”, Die Pharmazia, 2005, 60， 705-708.

115
Yi Yang, Zhiwei Deng, P. Proksch, Wenhan Lin* “two new 18-en-oleane derivatives from marine mangrove plant, Barringtonia racemosa”Die Pharmazia,2005,

60, 12-14.

116
Wenhan Lin, Liya Li, Hongzheng Fu, Isabel Sattler, Xueshi Huang, Susanne Grabley “New cyclopentenone derivatives from an endophytic Streptomyces sp.

isolated from the mangrove plant Aegiceras comiculatum” J. Antibiotic, 2005, 58, 594-598.

117
Mingjian Xu, Zhiwei, Deng, Jun L, Fu, HZ, Peter Proksch, Wenhan*, “chemical constituents from the mangrove plant, Aegiceras corniculatum”, J. Nat.Prod.,

2004, 67, 762-766.

118
Yan Qiu, Zhiwei Deng, Yuehu Pei, Fu hz, Li J, Peter Proksch, Wenhan Lin*, “sesterterpenoids from the marine sponge Hyrtios erectus”, J.Nat.Prod. 2004,67,

921-924.

119
Han L, Huang XS, Sattler I, Dahse HM, Fu HZ, Wenhan Lin*, Grabley S. “New diterpenoids from the marine mangrove Bruguiera gymnorrhiza” J. Nat. Prod.

2004, 67, 1620-1623.

120
Lv F, Deng ZW, Li J, Fu HZ, Soest RWM, Proksch P, Wenhan Lin* “Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta”

J. Nat. Prod. 2004, 67, 2033-2036.

121
Wenhan Lin，Gernot Brauers, Rainer Ebel, Victor Wray, Albrecht Berg, sudarsono, Peter Proksch, “novel chromone derivatives from the fungus Aspergillus

versicolor isolated from the marine

参编著作

1. “海洋天然产物”，林文翰主编，化学工业出版社

2. “天然有机化合物核磁共振波谱集”，杨峻山主编，林文翰副主编，化学工业出版社

3. “Frontiers in Marine Biotechnology”，Peter Proksch 主编，林文翰参编，Horizon bioscience

授权专利

序号

专利名称

发明人

专利权人

专利号

授权（颁证）年月

1

新片螺素类生物碱及其制备方法和抗艾滋病毒用途

林文翰等

北京大学

ZL 200810223494.4

2013,1

2

Tagasin C及其同系物在制备抗肿瘤药物中的应用

林文翰等

北京大学

ZL200610081051.7

2012,3