肖苏龙，副研究员，博士生导师

Tel: 010-******

E-mail: slxiao@bjmu.edu.cn

 
  教育经历

1994.09 – 1998.07  北京医科大学，药物化学专业，本科

2000.09 – 2004.07  北京大学，药物化学专业，硕士，导师：杨铭教授

2006.09 – 2011.01  北京大学，药物化学专业，博士，导师：杨铭教授

2007.09 – 2008.09  北京大学-彼埃尔-玛丽居里大学，中法联合培养博士（留学基金委），导师：杨铭教授（中），张勇民院士（法）

工作经历

1998. 08 – 1999.07       北京医科大学，天然药物及仿生药物国家重点实验室，实习研究员

1999. 08 – 2014.07       北京大学医学部，天然药物及仿生药物国家重点实验室，助理研究员

2014. 08 – 2017.12       北京大学医学部，天然药物及仿生药物国家重点实验室，副研究员

2018. 01 – 至今           北京大学医学部，药物化学系，副研究员

研究方向

调控病毒-细胞识别的新型抗病毒药物的研究；

非天然氨基酸定点修饰蛋白质的生物治疗研究；

环糊精的结构修饰及多价化在药物研发中的应用

 
 
科研基金 
1.国家自然科学基金面上项目（主持）：基于五环三萜-HR2螺旋结构域选择性结合广谱抑制病毒-细胞膜融合的机制研究（No. 21877007，2019-2022）
2.植物化学与西部资源持续利用国家重点实验室 （开放课题）（主持）：缀合环糊精的三萜新衍生物的合成及其调控流感病毒进入细胞的分子机制研究 （2019.01-2021.01）
3.国家自然科学基金重点项目（参与）：海洋微生物来源新型抗流感病毒先导分子的发现与作用机制研究（No. 81630089，2017-2021）
4.国家自然科学基金面上项目（主持）：新型五环三萜-环糊精多价物的合成、抗流感进入构效关系及分子机制研究（No. 81573269，2016-2019）
5.国家自然科学基金面上项目（主持）：以“病毒进入细胞”为靶的五环三萜抗病毒药物研究（No. 81373271，2014-2017）
6.国家自然科学基金国际合作与交流项目（参与）：基于三萜类化合物调控流感病毒与宿主细胞识别的新型抗病毒药物研究 （No. 81361168002, 2014-2017）
7.国家自然科学基金青年基金（参与）：调控流感病毒与宿主细胞识别的传统中药活性成分及其分子机制研究（No. 81202975,2013-2015）
8.科技部“973”重大研究计划（参与）：基于基因密码子扩展的蛋白质标记新方法（No. 2010CB912300，2010-2014）
 

荣誉奖励
1.2016年度北京大学医学部SCI论文引用奖（2017.03）
2.2015年中国药学大会暨第十五届中国药师周优秀论文二等奖 (2015.11)
3.北京大学医学部大学生创新实验一等奖（指导教师）（2014.12）
4.第三届中法药学交流会暨产业化推进会优秀墙报奖 三等奖 （2014.08）
5.北京大学黄廷芳/信和青年杰出学者奖（2013.12）
6.北京大学医学部优秀共产党员（2012.06）
7.第十届全国青年药学科技工作者科研成果交流会优秀论文一等奖（2010.07）
8.Best Poster Award in 2ND ASICEF Workshop on Interdisciplinary Research Topics. (2008.06)
9.教育部高等学校科学技术奖(自然科学奖)二等奖(基于病毒基因转录调控机制探索抗HIV新靶标及其新型抑制剂的研究)(第五)(2007.01)
10.北京市科技进步二等奖（项目名称：以核酸分子识别为基础新型HIV抑制剂的研究）（第六）（2005.02）
11.教育部提名国家科学技术奖（自然科学奖）二等奖（项目名称：抗肿瘤抗病毒药物研究中的分子识别）（第五）（2004.02）
12.第六届全国青年药学科技工作者学术交流会优秀论文一等奖（第三）（2002.09）
13.北京大学医学部优秀教师（2002.09）
 
代表性论文

1.Wang H, Xu R, Liang S, Ran F, Zhang L, Zhang Y, Zhou D, Xiao S.* Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis. Chin. Chem. Lett. 2020, 31(2), 333-336

2.Wang Y,# Li S,# Tian Z, Sun J, Liang S, Zhang B, Bai L, Zhang Y, Zhou X, Xiao S, Zhang Q, Zhang L, Zhang C,* Zhou D.*Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction. Nucleic Acids Res. 2019,47(19), e114.

3.Liang S,# Li M,# Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem. 2019, 166, 328-338.

4.Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem. 2019, 163,  560-568.

5.Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,* Xiao S.* Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates. Chin. Chem. Lett. 2019, 30(3), 690-693.

6.Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv. 2018, 11(4), eaau8408.

7.Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. Sin. Chim. 2018, 48(11), 589-599.

8.Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents. Eur. J. Med. Chem. 2018, 146, 194-205

9.Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.* Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Med. Res. Rev. 2018, 38(3), 951-976.

10.Shi Y,# Si L,# Han X,# Fan Z, Wang S, Tian Z, Li M, Sun J, Jin H, Zhang Y, Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity. MedChemComm. 2017, 8, 1531-1541

11.Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors. Chin. J. Chem. 2017, 35(8), 1322-1328.

12.Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q, Zhou D.* Redirecting killer T cells through incorporation of azido sugars for tethering ligands. Chembiochem. 2017, 18(21), 2082-2086.

13.Han X,# Si L,# Shi Y, Fan Z, Wang S, Tian Z, Li M, Sun J, Jiao P, Ran F, Zhang Y, Zhou D, Xiao S.* Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives. Molecules 2017, 22(7), 1018.

14.Tian Z,# Si L,# Meng K, Zhou X, Zhang Y, Zhou D, Xiao S.*  Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates. Eur. J. Med. Chem. 2017, 134, 133-139.

15.Tian Z, Meng K, Shi Y, Zhang N, Liu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated α-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis. Tetrahedron 2017, 73 (17), 2512-2517. （"Front Cover Article"）

16.Wu S, Yang L, Sun W, Si L, Xiao S, Wang Q, Dechoux L, Thorimbert S, Sollogoub M, Zhou D, Zhang Y. Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors. Eur. J. Med. Chem.; 2017, 130, 308-319.

17.Si L,# Xu H,# Zhou X, Zhang Z, Tian Z, Zhang B, Niu Z, Yao T, Wang Y, Li S, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science 2016, 354(6316), 1170-1173.

18.Wu Y, Zhu H, Zhang B, Liu F, Chen J, Wang Y, Wang Y, Zhang Z, Wu L, Si L, Xu H, Yao T, Xiao S, Xia Q, Zhang L, Yang Z, Zhou D.* Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion. Bioconjug. Chem. 2016, 27(10), 2460-2468.

19.Xiao S,* Wang Q, Si L, Zhou X, Zhang Y, Zhang L, Zhou D.* Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors. Eur. J. Med. Chem. 2016, 124, 1-9.

20.Han X, Shi Y, Si L, Fan Z, Wang H, Xu R, Jiao P, Meng K, Tian Z, Zhou X, Jin H, Wu X, Chen H, Zhang Y, Zhang L, Xiao S,* Zhou D.* Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors. MedChemComm. 2016, 7, 1932-1945. ("HOT" Article)

21.Xu H, Wang Y, Lu J, Zhang B, Zhang Z, Si L, Wu L, Yao T, Zhang C, Xiao S, Zhang L, Xia Q,* Zhou D.* Re-exploration of the codon context effect on amber codon-guided incorporation of non-canonical amino acids in E. coli by the blue-white screening assay. Chembiochem. 2016, 17, 1-12.

22.Yu F,* Wang Q, Wang H, Si L, Liu J, Han X, Xiao S, Zhang L, Zhou D.* Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors. Chin. Chem. Lett. 2016, 27, 711-713.

23.Han Wang,# Renyang Xu,# Yongying Shi, Longlong Si, Pingxuan Jiao, Zibo Fan, Xu Han, Xingyu Wu, Xiaoshu Zhou, Fei Yu, Yongmin Zhang, Lihe Zhang, Demin Zhou*, Sulong Xiao*. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur. J. Med. Chem. 2016, 110, 376-388.

24.俞飞,* 郑永祥, 彭逸云, 周德敏, 肖苏龙*. 齐墩果酸A环及C环内酯衍生物的设计合成. 有机化学. 2016, 36, 512-519.

25.Sulong Xiao,* Longlong Si, Zhenyu Tian, Pingxuan Jiao, Zibo Fan, Kun Meng, Xiaoshu Zhou, Han Wang, Renyang Xu, Xu Han, Ge Fu,Yongmin Zhang, Lihe Zhang, Demin Zhou*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials. 2016, 78, 74-85.

26.肖苏龙,* 王晗, 王琪, 韩旭, 徐仁洋, 孟坤, 田振宇, 张礼和, 周德敏.* 基于五环三萜先导结构的抗病毒抑制剂研究进展. 中国科学（化学）. 2015, 45(9), 865-883.

27.Han Wang,# Fei Yu,# Yiyun Peng, Qi Wang, Xu Han, Renyang Xu, Xiaoshu Zhou, Chuanxing Wan, Zibo Fan, Pingxuan Jiao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao.* Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. European Journal of Medicinal Chemistry. 2015, 102, 594-599

28.Zheng Yongxiang, Yu Fei, Wu Yiming, Si Longlong, Xu Huan, Zhang Chuanling, Xia Qing, Xiao Sulong, Wang Qi, He Qiuchen, Chen Peng, Wang Jiangyun, Zhang Lihe, Taira Kazunari, Zhou Demin.* Broaden the versatility of lentiviral vector as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res., 2015, 43(11),:e73

29.Maorong Yu, Longlong Si, Yufei Wang, Yiming Wu, Fei Yu, Pingxuan Jiao, Yongying Shi, Han Wang, Sulong Xiao, Ge Fu, Ke Tian, Yitao Wang, Zhihong Guo, Xinshan Ye, Lihe Zhang and Demin Zhou.* Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses. J. Med. Chem. 2014, 57(23): 10058-10071

30.Sulong Xiao, Qi Wang, Longlong Si, Yongying Shi, Han Wang, Fei Yu, Yongmin Zhang, Yingbo Li, Yongxiang Zheng, Chuanling Zhang, Chunguang Wang, Lihe Zhang, Demin Zhou.* Synthesis and anti-HCV entry activity studies of new β-cyclodextrin-pentacyclic triterpene conjugates. ChemMedChem., 2014, 9(5): 1060-1070.

31.Fei Yu, Yiyun Peng, Qi Wang, Yongying Shi, Longlong Si, Han Wang, Yongxiang Zheng, Emily Lee, Sulong Xiao,* Maorong Yu, Yingbo Li, Chuanling Zhang, Hengli Tang, Chunguang Wang, Lihe Zhang, and Demin Zhou,* Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors. Eur. J. Med. Chem., 2014, 77: 258-268.

32.Sulong Xiao, Ming Yang, Fei Yu, Lihe Zhang, Demin Zhou, Pierre Sinaÿ, Yongmin Zhang. Synthesis of four mono-functionalized α-cyclodextrin derivatives for confirming DIBAL-H-promoted bis-de-O-methylation mechanism. Tetrahedron. 2013, 69(20): 4053-4060.

33.Wang Han,# Wang Qi#, Xiao Sulong#, Sun Dian, Ye Min, Zhang Lihe, Zhou Demin. Elucidation of the pharmacophore of echinocystic acid as a new lead for blocking HCV entry. Eur. J. Med. Chem., 2013, 64: 160-168.

34.Fe Yu, Qi Wang, Zhen Zhang, Yiyun Peng, Yongying Shi, Yongxiang Zheng, Sulong Xiao*, Han Wang, Yongyan Qiu, Xiaoxi Huang, Chuanke Zhao, Chuanling Zhang, Dian Sun, Lihe Zhang and Demin Zhou*. Development of oleanane-type triterpene as a new class of HCV entry inhibitors. J. Med. Chem., 2013, 56, 4300-4319.

35.Su-long Xiao, Qi Wang, Fei Yu, Yi-yun Peng, Ming Yang, Matthieu Sollogoub, Pierre Sinaÿ, Yong-min Zhang, Li-he Zhang, De-min Zhou. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20 (18), 5616-5622

36.Su Long Xiao, De Min Zhou, Ming Yang, Fei Yu, Li He Zhang, Pierre Sinaÿ, Yong Min Zhang. Synthesis of two mono-deoxy β-cyclodextrin derivatives as useful tools for confirming DIBAL-H promoted bis-de-O-methylation mechanism. Chinese Chemical Letter. 2012, 23(12): 1315-1318.

37.Sulong Xiao, Demin Zhou, Ming Yang *, Pierre Sinaÿ, Matthieu Sollogoub, Yongmin Zhang *.Facile preparation of two tetrols from permethylated α-cyclodextrin and unambiguous NMR analysis. Tetrahedron Letters. 2011, 52(41): 5273-5276

38.Sulong Xiao, Ming Yang, Pierre Sinaÿ, Matthieu Sollogoub*, Yongmin Zhang*. Diisobutylaluminum hydride (DIBAL-H) promoted secondary rim regioselective demethylations of permethylated β-cyclodextrin: a mechanistic proposal. Eur. J. Org. Chem.. 2010, 2010(8): 1510-1516

39.Zhang, Z.; Wang, H.; Du, L. Y.; Chen, K. B.; Xiao, S. L.; Yu, F.; Zhang, L. H.; Zhou, D. M. Discovery and development of antiviral drugs. Journal of Chinese Pharmaceutical Sciences. 2010, 19(6): 409-422

40.Zhi-Dong Xu, Min Wang, Su-Long Xiao, Ming Yang. Novel peptide derivatives of Bleomycin A5: synthesis, antitumor activity and interaction with DNA. Bioorg. Med. Chem. Lett. 2005,15(18)：3996-3999

41.王  敏, 肖苏龙, 徐志栋, 屠鹏飞, 于晓琳, 杨  铭. 具有抗HIV-1 Tat-TAR RNA结合活性的海藻糖新衍生物的设计和合成. 中国新药杂志. 2004, 13(10): 907-911

42.Wang Min, Xu Zhidong, Tu Pengfei, Yu Xiaolin, Xiao Sulong, Yang Ming. α,α-Trehalose derivatives bearing guanidino groups as inhibitors to HIV-1 Tat–TAR RNA interaction in human cells. Bioorganic and Medicinal Chemistry Letters. 2004, 14(10): 2585-2588

43.Zhi-Dong Xu, Min Wang, Su-Long Xiao, Yan-Juan Zhang, Ming Yang. Novel Bleomycin analogues: synthesis, antitumor activity, and interaction with DNA. Helvetica Chimica Acta. 2004, 87(11): 2834-2841

44.Zhi-Dong Xu, Min Wang, Su-Long Xiao, Chun-Li Liu and Ming Yang.  Synthesis, biological evaluation and DNA binding properties of novel Bleomycin analogues. Bioorganic & Medicinal Chemistry Letters. 2003, 13(15): 2595–2599

45.Zhi-Dong Xu, He Liu, Su-Long Xiao, Ming Yang, Xian-He Bu. Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline. Journal of Inorganic Biochemistry. 2002, 90(3-4): 79-84

46.Xu Zhidong, Liu He, Wang Min, Xiao Sulong, Yang Ming, Bu Xianhe. Cobalt (II) complex of 6,7-dicycanodipyridoquinoxaline with antitumor activities: synthesis, crystal structure and binding with DNA. Journal of Chinese Pharmaceutical Sciences. 2002, 11(4): 125-131

47.Zhi-Dong Xu, He Liu, Min Wang, Su-Long Xiao, Ming Yang, Xian-He Bu.  Manganese (II) complex of 6,7-dicycanodipyridoquinoxaline with antitumor activities: synthesis, crystal structure and binding with DNA. Journal of Inorganic Biochemistry. 2002, 92(3-4): 149–155

48.肖苏龙, 杨　铭.人免疫缺陷病毒-1整合酶及其抑制剂的研究进展。国外医学（药学分册）. 2002, 29(3): 157-161

49.Su-long Xiao, Wei Lin, Chao Wang, Ming Yang. Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry Letters. 2001, 11(4): 437-441

50.杨铭, 肖苏龙, 周田彦, 张家美, 王保怀, 李芝芬, 孟兴莲, 王夔. 新的手性铂络合物与DNA两种不同结合方式中的分子识别. 北京医科大学学报. 2000, 32(3): 198-202

 
参编著作

1.药物研究中的分子识别（第2版）（杨铭主编，北京大学医学出版社，2015.8）

2.抗肿瘤抗病毒药物与核酸相互作用的分子机制（杨铭主编，P99-138，北京大学医学出版社，2009.4）

3.结构生物学概论（杨铭主编，P68-89，北京医科大学出版社, 2002.7.）

 授权或申请专利
1.一种新的三萜-环糊精共价化合物及其制备方法和用途。周德敏、肖苏龙、司龙龙、俞飞、史勇英、王晗、张礼和（申请号：ZL 2013 1 0684679.6）
2.三萜衍生物及其抗流感用途。（申请号：201210402726.9）（发明人：周德敏、于茂荣、肖苏龙、俞飞、彭逸云、邱允俨、张礼和）（2012）
3.刺囊酸衍生物及其生物转化方法和用途。（申请号：ZL 2012 1 0015068.8）（发明人：周德敏，王晗， 叶敏，肖苏龙，孙迪安，张礼和）（2012）
4.定点突变和定点修饰的病毒膜蛋白、其制备方法及其应用 （ZL 2012 1 0214038.X，周德敏，郑永祥，赵传科，张传领，俞飞，肖苏龙，张礼和）
5.定点突变和定点修饰的生长激素、其制备方法及其应用 （ZL 2012 1 0214451.6，周德敏，张传领，肖苏龙，张雨帆，俞飞，赵传科，陈景贤，张礼和）
6.具有抗HIV和抗癌活性的3-取代的β-咔啉新化合物，制备方法及其组合物和用途。（ZL 011 44531.9，杨铭，林伟，于晓琳，肖苏龙）
7.具有抗病毒活性的氨基糖苷类化合物及其制备方法。（ZL 02 1 53987.1，杨铭，王敏，徐志栋，肖苏龙）

 培养研究生

邱允俨  （2011）      田振宇（2016-2018）    李    曼 （2016-2019）      梁烁斌 （2017-2019）   陈樱璎 （2017-    ）

高倩倩 （2018-   ）   易延亮 （2019-    ）

协助培养研究生

王   晗  （2009-2012）  俞    飞 （2010-2013）   彭逸云 （2011-2013）  史勇英 （2012-2014） 韩    旭 （2014-2016）

徐仁洋 （2014-2016）  司龙龙 （2012-2017）    焦平轩 （2014-2019）  李海伟 （2017-2019）