北京大学药学院导师教师师资介绍简介-熊德彩

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E-mail: decai@bjmu.edu.cn

Tel: 010-******

教育及工作经历

2001.8-2005.7 理学学士，兰州大学化学化工学院化学基地班

2005.8-2010.7 理学博士，北京大学药学院化学生物学系，导师：叶新山教授

2010.8-至今助理研究员、副教授，北京大学药学院、天然药物及仿生药物国家重点实验室

研究领域

基于糖的化学、药物化学及化学生物学研究

科研项目

1. 2018.1 - 2021.12，糖类化合物的氟代修饰方法研究, 国家自然科学基金面上项目(21772006)，项目负责人。

2. 2016.1 - 2019.12，光控的糖基化反应研究, 国家自然科学基金面上项目(21572012)，项目负责人。

4．2012.1 - 2015.12，糖链修饰与糖衍生物的研制，生物和医药技术领域863计划“糖工程关键技术与重大产品开发”项目所属课题(2012AA021504)，子课题负责人。

5．2013.10 - 2015.12，北京市支持中央高校共建项目-青年英才计划，(YETP0063)，项目负责人。

6．2014.1 - 2016.6，糖基化磷脂酰肌醇（GPI）锚的一釜多组分合成研究，北京市自然科学基金（2142015），项目负责人。

7. 2012.1 - 2014.12，类聚糖的合成方法及策略研究，国家自然科学基金青年科学基金项目(21102008)，项目负责人。

荣誉奖励

（1）叶新山，熊德彩，王媛，张礼和， “糖化学和基于糖的药物研究”，2010 年教育部高等学校自然科学奖，二等奖

（2）叶新山，熊德彩，郑秀静，王媛，吴艳芬，李勤，“基于糖类的药物先导化合物的发现和优化研究”， 2011 年中国药学会科学技术奖，一等奖

（3）叶新山，熊德彩，耿轶群，王冠男，张礼和，“寡糖的合成及某些基于糖类的药物发现”, 2013年度国家自然科学奖，二等奖

（4）北京大学医学部大学生创新实验指导教师三等奖

（5）2015年度北京大学医学部青年岗位能手

（6）2015年度北京大学医学部优秀教师

（7） 2016年度北京大学医学部优秀共产党员

发表论文

1. Miao Liu, Bo-Han Li, De-Cai Xiong,* Xin-Shan Ye,* "O-Glycosylation Enabled by Acetamidyl Glycosides", J. Org. Chem., 2018, 83(15), 8292–8303.

2. Shengbiao Tang, Qiannan Zheng, De-Cai Xiong,* Shende Jiang, Qin Li, Xin-Shan Ye*, “Stereocontrolled Synthesis of 2-Deoxy-C-Glycopyranosyl Arenes Using Glycals and Aromatic Amines”, Org. Lett. 2018, 20, 3079–3082.

3. Dong Wang, De-Cai Xiong*, Xin-Shan Ye*, “A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM5)”, Chin. Chem. Lett., 2018, 29, 1340-1342.

4. Gao-Lan Zhang, Meng-Man Wei, Chengcheng Song, Yu-Feng Ma, Xiu-Jing Zheng, De-Cai Xiong, Xin-Shan Ye*,“Chemical synthesis and biological evaluation of penta- to octa- saccharide fragments of Vi polysaccharide from Salmonella typhi” Org. Chem. Front., 2018, 5, 2179–2188.

5. Runze Mao, Lifeng Sun, Yong-Shi Wang, Min-Min Zhou, De-Cai Xiong, Qin Li*, and Xin-Shan Ye*, “N-9 Alkylation of purines via light-promoted and metal-free radical relay”, Chin. Chem. Lett., 2018, 29, 61-64.

6. Gao-Lan Zhang, Lin Yang, Jingjing Zhu, Mengman Wei, Wanjun Yan, De-Cai Xiong, Xin-Shan Ye*, “Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen from Salmonella typhi”, Chem. Eur. J. 2017, 23, 10670-10677.

7. Yong Wu, De-Cai Xiong, Si-Cong Chen, Yong-Shi Wang, Xin-Shan Ye*, “Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units”, Nat. Commun. 2017, 8, 14851.

8. Yang Yu, De-Cai Xiong*, Run-Ze Mao, and Xin-Shan Ye*, “Visible Light Photoredox-Catalyzed O-Sialylation Using Thiosialoside Donors”, J. Org. Chem., 2016, 81(16), 7134–7138.

9. Lifeng Sun, Xiaowei Wu, De-Cai Xiong, Xin-Shan Ye*, “Stereoselective Koenigs–Knorr Glycosylation Catalyzed by Urea”, Angew. Chem. Int. Ed., 2016, 55, 8041-8044.

10. Yang Yu+, De-Cai Xiong+ and Xin-Shan Ye*, “2-Trifluoromethylthiolation of Glycals”, Org. Biomol. Chem. 2016, 14, 6403-6406. (+co-first author)

11. Run-Ze Mao+, De-Cai Xiong+, Fan Guo, Qin Li, Jinyou Duan and Xin-Shan Ye*，“Light-driven highly efficient glycosylation reactions” Org. Chem. Front., 2016, 3, 737–743. (+co-first author)

12. Chen-Fu Liu+, De-Cai Xiong+, Xin-Shan Ye*, “KOtBu-mediated aromatic O-glycosylation of 1,2-anhydrosugar and aryl boronic acid”, Tetrahedron Lett., 2016, 57, 1372-1374. (+co-first author)

13. Shengbiao Tang, De-Cai Xiong, Shende Jiang*, and Xin-Shan Ye*， “Nitro-polyols via Pyridine Promoted C═C Cleavage of 2-Nitroglycals. Application to the Synthesis of (−)-Hyacinthacine A1”, Org. Lett. 2016, 18(3), 568–571.

14. Bang Wang, De-Cai Xiong*, and Xin-Shan Ye*, “Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis”, Org. Lett. 2015, 17(22), 5698–5701.

15. Run-Ze Mao+, Fan Guo+, De-Cai Xiong*, Qin Li, Jinyou Duan, and Xin-Shan Ye*, “Photoinduced C–S Bond Cleavage of Thioglycosides and Glycosylation”, Org. Lett. 2015, 17(22), 5606-5609. (+co-first author)

16. Wenming Li, Youhong Niu, De-Cai Xiong, Xiaoping Cao, and Xin-Shan Ye*, “Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors”, J. Med. Chem. 2015, 58, 7972–7990.

17. Xuemei Yang+, De-Cai Xiong+, Chengcheng Song, Guihua Tai and Xin-Shan Ye*, “Synthesis of N-dialkylphosphoryl iminosugar derivatives and their immunosuppressive activities”, Org. Biomol. Chem. 2015, 13, 9364-9368. (+co-first author)

18. Shao-Tao Bai+, De-Cai Xiong+, Youhong Niu, Yan-Fen Wu*, Xin-Shan Ye*, “Synthesis of novel N-glycoside derivatives via CuSCN-catalyzed reactions and their SGLT2 inhibition activities”, Tetrahedron, 2015, 71, 4909-4919. (+co-first author)

19. Yingguo Liu, Xiaxi Li, De-Cai Xiong, Binhan Yu, Xiaoping Pu*, and Xin-Shan Ye*, “Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents”, Eur. J. Med. Chem., 2015, 95, 313-323.

20. De-Cai Xiong+, Jingjing Zhu+, Ming-Jie Han, Hui-Xin Luo, Cong Wang, Yang Yu, Yuqian Ye, Guihua Tai, and Xin-Shan Ye*, “Rapid Probing of Sialylated Glycoproteinsin vitro and in vivo via Metabolic Oligosaccharide Engineering of Minimal Cyclopropene Reporter”, Org. Biomol. Chem. 2015, 13, 3911-3917. (+co-first author)

21. De-Cai Xiong, An-Qi Yang, Yang Yu, and Xin-Shan Ye*, “2-Pyridyl Glycoside: An Alternative Glycosyl Donor in Preactivation Protocol”, Tetrahedron Lett., 2015, 56, 211-214.

22. Qi Qin, De-Cai Xiong, and Xin-Shan Ye*,“Additive-controlled Stereoselective Glycosylations of 2,3-Oxazolidinone Protected Glucosamine or Galactosamine Thioglycoside Donors with Phenols Based on Preactivation Protocol”, Carbohydr. Res., 2015, 403, 104-114.

23. De-Cai Xiong+, Yichuan Zhou+, Yuxin Cui, and Xin-Shan Ye*, “Synthesis of triazolyl-linked polysialic acids”, Tetrahedron 2014, 70, 9405-9412. (+co-first author)

24. De-Cai Xiong, Chao Gao, Wenming Li, Yuan Wang, Qin Li, and Xin-Shan Ye*, “Synthesis of 2-Deoxy-C-glycosides via Lewis Acid-Mediated Rearrangement of 2,3-Anhydro-1-thiopyranosides”, Org. Chem. Front., 2014, 1, 798-806.

25. Chen-Fu Liu, De-Cai Xiong, and Xin-Shan Ye*, “‘Ring Opening−Ring Closure’ Strategy for the Synthesis of Aryl‑C‑glycosides”, J. Org. Chem., 2014, 79(2), 4676–4686.

26. Xiaowei Wu, Fu-Yu Zhang, Jingjing Zhu, Chengcheng Song, De-Cai Xiong, Yifa Zhou, Yuxin Cui, and Xin-Shan Ye*, “N-Arylated-Lactam-Type Iminosugars as New Immunosuppressive Agents: Discovery, Optimization, and Biological Evaluation”, Chem. Asian. J. 2014, 9, 2260-2271.

27. Peng Peng, De-Cai Xiong, Xin-Shan Ye*, “ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis”, Carbohydr. Res., 2014, 384, 1-8.

28. Fei-Fei Xu, Yue Wang, De-Cai Xiong, and Xin-Shan Ye*, “Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2”, J. Org. Chem., 2014, 79 (2), 797–802.

29. Ming-Jie Han, De-Cai Xiong, and Xin-Shan Ye*, “Enabling Wittig Reaction on Site-Specific Protein Modification”, Chem. Commun. 2012, 48(90), 11079-11081.

30. Yuan-Yuan Wang, De-Cai Xiong, Qin Li, Yuan Wang, Xin-Shan Ye*, “Syntheses of novel acarviosin analogs with anhydro or unsaturated sugar moieties”, Tetrahedron 2012, 68, 9355-9363.

31. De-Cai Xiong, Xin-Shan Ye*, “Benzenesulfinyl Morpholine”, Encyclopedia of Reagents for Organic Synthesis, 2012, DOI: 10.1002/047084289X.rn01519.

32. Gen Li, De-Cai Xiong, Xin-Shan Ye*, “Synthesis of a-C-Glycosides by Samarium Diiodide Mediated Coupling of Glycosyl Pyridyl Sulfones with Alkenes”, Synlett 2011, 2410–2414.

33. Chao Gao, De-Cai Xiong, Yuan Wang and Xin-Shan Ye*, “Stereoselective synthesis of 2-deoxy-pyranosides via the Lewis acid-promoted rearrangement of 2,3-anhydrosugars”, J. Chin. Pharm. Sci. 2011, 20(2), 146-150.

34. De-Cai Xiong, Li-He Zhang and Xin-Shan Ye*, “Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2-Deoxy-C-glycosides”, Org. Lett. 2009, 11(8), 1709-1712.

35. De-Cai, Xiong, Li-He Zhang and Xin-Shan Ye*, “Bromodimethylsulfonium bromide-silver triflate: A new powerful promoter system for the activation of thioglycosides ”, Adv. Synth. Cat. 2008, 350(11-12), 1696-1700.