李颖博 助理研究员 liyb@bjmu.edu.cn
　　教育及工作经历
　　2001.09 – 2005.07北京大学医学部，药学专业，本科
　　2005.09 – 2007.07北京大学医学部，药理专业，硕士
　　2007.09 – 2011.08澳门大学，生物医药专业，博士
　　2011.11 –今，北京大学医学部，天然药物及仿生药物国家重点实验室
　　研究领域
　　1.肿瘤耐受相关基因及调节机制
　　2.抗肿瘤、抗病毒药物筛选及作用机制的研究
　　主持科研基金
　　1. 国家自然科学基金青年基金：基于c-Met的靶向抑制联合放、化疗在结直肠癌治疗中的药效学评价及机制研究
　　2. 教育部博士点新教师基金：多靶点抗肿瘤化合物EMB-3的机制研究
　　代表性论文
1. Li YB¹, Yan X¹, Li RD, Liu P, Sun SQ, Wang X, Cui JR, Zhou DM, Ge ZM, Li RT. Discovery of novel heteroarylmethylcarbamodithioates as potent anticancer agents: Synthesis, structure-activity relationship analysis and biological evaluation.Eur J Med Chem. 2016, 112:217-230.
2. Li Y, Wang J, Gao X, Han W, Zheng Y, Xu H, Zhang C, He Q, Zhang L, Zhou D. c-Met targeting enhances the effect of irradiation and chemical agents against malignant colon cells harboring a KRAS mutation. PlosOne. 2014,9(11):e113186.
3. Li YB, Wang ZQ, Yan X, Chen MW, Bao JL, Wu GS, Ge ZM, Zhou DM, Wang YT, Li RT. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer Lett. 2013, 28: 340(1):88-96.
4. Zhang J¹, Li Y¹, Fang X, Zhou D, Wang Y, Chen M. TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. Int J Pharm. 2014, 476(1-2):185-198.
5. Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SM, Wang YT. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013, 65(3):700-9.
6. Li YB, Gao JL, Lee SM, Zhang QW, Hoi PM, Wang YT. Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt. Int J Mol Med. 2011, 27(2):205-11.
7. Li YB, Lin ZQ, Zhang ZJ, Wang MW, Zhang H, Zhang QW, Lee SM, Wang YT, Hoi PM. Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone from Polygonum cuspidatum in PC12 Cells. Planta Med. 2011, 77(4):354-61.
8. Li YB, Wang R, Wu HL, et al. Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells. Oncol Rep. 2008, 20(3):549-56.
　　
　　参与编写专著：
　　Pharmacological Activity Based Quality Control of Chinese Herbs, Nova Science Publishers, Inc., USA, 2008. (ISBN: 978-1-60456-823-3)