田 超
讲师 (助理教授)
联系方式：
电话：+86-
Email：tianchao@bjmu.edu.cn
北京市海淀区学院路38号北京大学医学部药学院632
教育背景：
2002-2006 北京大学药学院本科
2006-2008 北京大学药学院硕士
2008-2011 北京大学药学院博士
2011至今 北京大学药学院讲师
个人荣誉：
2019年度北京大学医学部青年岗位能手
2018年度北京大学医学部优秀教师
2014年度北京大学医学部优秀教师
研究方向：
针对肿瘤的药物化学研究，主要研究方向包括：
1）针对CHK1（细胞周期检查点激酶1）的抗肿瘤增敏剂的研究；
2）新型肿瘤血管阻断剂的研究；
3）针对KRAS突变型肿瘤的CHK1/MK2双靶点抑制剂的研究。
基金：
作为项目负责人承担国家自然科学基金青年项目No. **
项目名称：非ATP竞争型CHK1抑制剂作为抗肿瘤增敏和抗耐药剂的设计、合成及活性评价
发表文章：
1. Chao Tian*, Xuanzhen Chen, Zhili Zhang, Xiaowei Wang, Junyi Liu Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl) methanone analogues as potent anti-tubulin polymerization agents.European Journal of Medicinal Chemistry 2019; 183: 111679.
2. Chao Tian*, Zifei Han, Yuanxin Li, Meng Wang, Jiajia Yang, Xiaowei Wang, Zhili Zhang, Junyi Liu* Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstituted-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d] pyrimidine analogues as novel CHK1 inhibitors. European Journal of Medicinal Chemistry 2018; 151: 836-848.
3. Chao Tian, Meng Wang, Zifei Han, Fang Fang, Zhili Zhang, Xiaowei Wang, Junyi Liu* Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents European Journal of Medicinal Chemistry 2017; 138: 630-643.
4. Meng Wang, Jiajia Yang, Mengmeng Yuan, Liangmin Xue, Hao Li, Chao Tian, Xiaowei Wang, Junyi Liu*, Zhili Zhang* Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase. European Journal of Medicinal Chemistry, 2017; 128, 88-97.
5. Chao Tian, Zhili Zhang, Shouxin Zhou, Mengmeng Yuan, Xiaowei Wang, Junyi Liu* Synthesis, antifolate and anticancer activities of n5-substituted 8,10-dideazatetrahydrofolate analogues. Chemical Biology & Drug Design, 2016; 87: 444–454.
6. Xianling Ning, Ying Guo, Xiaowei Wang, Xiaoyan Ma, Chao Tian, Xueqi Shi, Renzong Zhu, Can Cheng, Yansheng Du, Zhizhong Ma, Junyi Liu* Design, Synthesis, and biological evaluation of (E)-3, 4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents. Journal of Medicinal Chemistry, 2014, 57(10), 4302-4312.