杜晓娟 教授
联系方式：
电话：（实验室）
Email: duxiaojuan100@bjmu.edu.cn
主要工作简历：
2011.08-今：北京大学基础医学院，细胞生物学系，教授
2001.10-2011.07：北京大学基础医学院，细胞生物学系，副教授
1995.10-1998.06：首都儿科研究所，生化与免疫，副研究员
1993.10-1995.09：首都儿科研究所，生化与免疫，助理研究员
1991.09-1993.09：首都儿科研究所，生化与免疫，实习研究员
教育经历：
1998.07-2001.07：德国Freiburg大学，生物学，博士
1988.09-1991.07：首都儿科研究所，生化与免疫，硕士
1982.09-1988.07：北京医科大学，临床医学，本科
研究方向：
细胞核仁蛋白在肿瘤发生中的作用机制及在肿瘤治疗中的作用
主要研究内容：
对肿瘤相关的核仁蛋白在RNA Pol I的转录以及Ribosomal RNA（rRNA）加工过程中的作用机制进行研究；同时，阐明核仁蛋白在介导p53和RB的降解以及c-Myc的稳定中的作用及机制。对核仁乙酰转移酶在激活RNA Pol I转录、参与18S rRNA的加工中的作用进行研究；发现在DNA损伤时，核仁蛋白通过乙酰化p53激活p53的转录活性；在细胞处于能量应激时，核仁蛋白调控核糖体发生与细胞自噬之间的转换。同时，核仁蛋白在有丝分裂中发挥重要作用。
承担的研究项目：
主持国家自然科学基金共7项、国家863计划项目1项、北京市教育委员会科技成果转化与产业化项目1项；参与973项目2项、创新团体3项。
近期主要发表文章：（^*责任作者）
1. Jingyi Zhang^#, Pengwei Ren^#, Da Xu^#, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du*and Baocai Xing*. Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc. Cancer Letters. 2018, 440-441(2019):106-115.
2. Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing* and Xiaojuan Du*. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucl Acids Res., 2018 Oct 12;46(18):9601-9616.
3. Tong Zheng, Min Lu, Ting Wang, Chunfeng Zhang, Xiaojuan Du*. NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression. BBA Mol Cell Res.2018, 12(1865): 1869-1877.
4. Huijiao Liu, Jiangnan Wang, Yun Liu, Min Lu, Lelin Hu, Chunfeng Zhang, Baocai Xing and Xiaojuan Du*. Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a Leucine-rich region. BBA Mol Cell Res., 2018, 1865 :1611-1620.
5. Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, Min Lu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma, Biochem. Biophys. Res. Commun.2018, 499: 1032-1038.
6. Ma T, Lu C, Guo Y, Zhang C, Du X*. Human U3 protein 14a plays an anti-apoptotic role in cancer cells. Biol. Chem.2017, 398(11):1247-1257.
7. Cai S, Liu X, Zhang C, Xing B, Du X*. Autoacetylation of NAT10 is critical for its function in rRNA transcription activation. Biochem. Biophys. Res. Commun.2017, 483: 624-629.
8. Liu X,Tan Y,Zhang C,Zhang Y,Zhang L,Ren P,Deng H,Luo J,Ke Y,Du X*. NAT10regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep.2016, 17(3): 349-366.
9. Wang Y,Zheng Z,Zhang J,Wang Y,Kong R,Liu J,Zhang Y,Deng H,Du X*,Ke Y*. A novel retinoblastoma protein (RB) E3 ubiquitin Ligase (NRBE3) Promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor. J Biol Chem.2015,290(47):28200-13.
10. Jin KM, Liu FF, Gu J, Du XJ^*andXing BC^*. N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis. Surgery.2013, 153: 518-25.
11. Wu J, Zhang Y, Wang, Y, Kong R, Hu L, Schuele R,Du X^*and Ke Y^*. Transcription repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. PLoS ONE.2012, 7(2): e31692.
12. Song JM, Lu M, Liu FF, Du XJ^*and Xing BC^*. AIB1 as an independent prognostic marker in hepatocellular carcinoma after Hepatic Resection. J Gastrointest Surg.2012, 16: 356-360.
13. Kong R, Zhang L, Hu L, Peng Q, Han W, Du X^*and Ke Y^*.hALP, A novelt-UTP, activates polymerase I transcription by binding and acetylating the upstream binding factor. J Biol Chem.2011, 286(9): 7139-48.
14. Hu L, Wang J, Zhang L, Kong R, Zheng Z, Han W, Du X^*and Ke Y^*. A small ribosomal subunit (SSU) processome component, the human U three protein 14a binds p53 and promotes p53 degradation. J Biol Chem.2011, 286(4): 3119-28.