（联系方式：Email: zhengl@bjmu.edu.cn; Tel: ）
北京大学心血管研究所副所长，教育部重点实验室主任助理。心血管代谢与蛋白质组学研究室主任，研究员(三级教授)，博士生导师，专业为病理生理学。本科毕业于北京师范大学化学系，本科毕业后进入中国科学院感光化学所工作，2000年进入全美心脏科第一的美国克利夫兰医院（Cleveland Clinic）攻读临床生物分析化学博士。博士毕业后留克利夫兰医院所属生物医学公司工作。2007年作为“985”引进人才进入北京大学心血管所担任副教授、研究室主任；2014年担任博士生导师；2015担任北京大学基础医学院研究员，博士生导师，研究室主任；2018年担任心血管研究所副所长，教育部重点实验室主任助理。担任中华医学会心血管分会基础学组委员，中国脂质与脂蛋白专业委员会青年副主任委员，中国研究型医院协会心血管循证和精准医学专业委员会副主任委员，中国心胸血管麻醉学会精准医学分会副秘书长，北京生理协会血管分会脂质代谢组组长。担任Cardiovascular Drugs and Therapy (IF=4.18), Cardiovascular & Hematological Disorders - Drug Targets, Lipid &Cardiovascular Research, 《中国心血管病研究》，《中国动脉硬化杂志》等杂志编委；Circulation, Nature Communication, Diabetologia, ACS Applied Materials & Interfaces, FASEB Journal, British Journal of Pharmacology, Free Radical Biology and Medicine, Cardiovascular Diabetology等杂志审稿人。
获得国家自然基金委“优秀青年基金”；中组部“****”青年拔尖人才基金；教育部“新世纪人才基金”等。并主持国自然血管重大专项培育基金，国自然面上基金与青年基金（5项），北京市面上基金（2项）等多项基金，作为研究骨干参加精准医学重大项目与973项目（2项）。获省部级奖2项，美国心脏协会“Pre-doctoral Fellowship Award”等。已发表SCI文章90篇（http://www.researchgate.net/profile/Lemin_Zheng），作为主要作者（通讯及第一作者）发表SCI论文60篇。SCI引用2612次。2010年发明专利通过了美国专利局以及欧洲专利局，2019年获中国专利1项。2014年获得国家CFDA心血管临床医学检验试剂盒一项，2020获得三项。
研究方向：
脂蛋白，脂质代谢，与心脑血管功能研究。研究心脑血管疾病，代谢性疾病，以及衰老等疾病状态下三者相互关系。脂蛋白研究重点为高密度脂蛋白（HDL），脂质代谢包括了肠道菌群影响的相关代谢。
血管功能包括心血管，脑血管等，特别是内皮细胞等研究。通过蛋白质组学与代谢组学技术来研究衰老相关的动脉粥样硬化等疾病中的重要代谢物，以及调控代谢的重要蛋白对血管功能影响。
结合新材料新技术研究在心脑血管功能方面的应用，包括治疗与体外诊断技术的应用与研究。结合纳米微粒材料对炎症细胞等进行标记与药物运输。

部分发表SCI论文（*为本人作为责任作者）：
1. Mingming Zhao, Lin Zhao, Xuelian Xiong, Yuan He, Wei Huang, Zihao Liu, Liang Ji, Bing Pan, Xuefeng Guo, Leibo Wang, Si Cheng, Ming Xu, Hongyuan Yang, Yuxin Yin, Minerva T. Garcia-Barrio, Y. Eugene Chen, Xiangbao Meng, *Lemin Zheng. TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice. Gastroenterology. 2020 Feb 25. pii: S0016-5085(20)30244-4. doi: 10.1053/j.gastro.2020.02.033.
2. Jingxuan Li, Yingyu Chen, Jianing Gao, Yue Chen, Changping Zhou, Xin Lin, Changjie Liu, Mingming Zhao, Yangkai Xu, Liang Ji, Zongzhe Jiang, *Bing Pan, *Lemin Zheng. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b. Cardiovasc Res. 2020 Jan 24. pii: cvaa011. doi: 10.1093/cvr/cvaa011.
3. Man Z, Lv Z, *Xu Z, Cui H, Liao Q, Zheng Lemin*, Jin X, He Q, Fu H*. Organic nanoparticles with ultrahigh stimulated emission depletion efficiency for low-power STED nanoscopy.Nanoscale. 2019;11(27):12990-12996
4. Jianping Li , Changping Zhou , Hongbing Xu , Robert Brook , Shengcong Liu , Tieci Yi , Yang Wang , Baihuan Feng , Mingming Zhao , Xu Wang , Qian Zhao , Jie Chen , Xiaoming Song , Tong Wang , Shuo Liu , Yi Zhang , Rongshan Wu , Jianing Gao , Bing Pan , Subramaniam Pennathur , Sanjay Rajagopalan , Yong Huo , *Lemin Zheng, *Wei Huang. Ambient Air Pollution is Associated with High-Density Lipoprotein Dysfunction in Healthy Adults. Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):513-522.
5. Xu H, Wang T, Liu S, Brook RD, Feng B, Zhao Q, Song X, Yi T, Chen J, Zhang Y, Wang Y, Lemin Zheng, Rajagopalan S, Li J, Huang W. Extreme Levels of Air Pollution Associated with Changes in Biomarkers of Atherosclerotic Plaque Vulnerability and Thrombogenicity in Healthy Adults: The Beijing AIRCHD Study. Circ Res. 2019 Mar;124(5):e30-e43.
6. Liu J, Zhao M, Zhu Y, Wang X, *Lemin Zheng, *Yin Y. LC-MS-Based Metabolomics and Lipidomics Study of High-Density-Lipoprotein-Modulated Glucose Metabolism with an apoA-I Knockout Mouse Model. J Proteome Res. 2018 Dec 13. doi: 10.1021/acs.jproteome.8b00290.
7. Liu D, Ji L, Zhao M, Wang Y, Guo Y, Li L, Zhang D, Xu L, Pan B, Su J, Xiang S, Pennathur S, Li J, Gao J, Liu P, *Willard B, *Lemin Zheng. Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory function in type 2 diabetes mellitus. J Mol Cell Cardiol. 2018 Sep;122:47-57.
8. Zhan R, Zhao M, Zhou T, Chen Y, Yu W, Zhao L, Zhang T, Wang H, Yang H, Jin Y, He Q, Yang X, Guo X, Willard B, Pan B, Huang Y, Chen Y, *Chui D, *Lemin Zheng. Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation. Cell Death & Disease. 2018 Jun 7;9(6):683.
9. Li D, Ke Y, Zhan R, Liu C, Zhao M, Zeng A, Shi X, Ji L, Cheng S, Pan B, *Lemin Zheng, *Hong H. Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice. Aging Cell. 2018 May 10:e12768.
10. Ke Y, Li D, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B, *Lemin Zheng, *Hong H. Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. Free Radic Biol Med. 2018 Jan 8;116:88-100.
11. He D, Zhao M, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L, Willard B, Mathew A, Chen Y, Pennathur S, Yin H, He Y, *Pan B, *Lemin Zheng. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1.Redox Biol.2018 May;15:228-242.
12. Lu J, Chen B, Chen T, Guo S, Xue X, Chen Q, Zhao M, Xia L, Zhu Z, *Lemin Zheng, *Yin H. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases. Redox Biol. 2017 Aug;12:899-907.
13. Fu Z, Zhou E, Wang X, Tian M, Kong J, Li J, Ji L, Niu C, Shen H, Dong S, Liu C, Vermorken A, Willard BB, *Zu L, *Lemin Zheng. Oxidized low density lipoprotein induced microparticles promote endothelial monocyte adhesion via intercellular adhesion molecule 1. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C567-C574.
14. Feng C, *Xu Z, Wang X, Yang H, *Lemin Zheng, *Fu H. Organic-nanowire-SiO2 core-shell microlasers with highly polarized and narrow emissions for biological imaging. ACS APPL MATER INTERFACES. 2017.Mar 1;9(8):7385-7391.
15. Zhang H, Wang X, Liao Q, Xu Z, Li H, *Lemin Zheng, *Fu H. Embedding Perovskite Nanocrystals into a Polymer Matrix for Tunable Luminescence Probes in Cell Imaging. Advanced Functional Materials.2017 February,Volume 27, Issue 7, **.
16. Zhang X, Wang X, Hu F, Zhou B, Chen HB, Zha D, Liu Y, Guo Y, *Lemin Zheng, *Xiu J. A novel hydrodynamic approach of drag-reducing polymers to improve left ventricular hypertrophy and aortic remodeling in spontaneously hypertensive rats. Int J Nanomedicine. 2016 Dec 13;11:6743-6751.
17. Niu C, Wang X, Zhao M, Cai T, Liu P, Li J, Willard B, Zu L, Zhou E, Li Y, Pan B, *Yang F, *Lemin Zheng. Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion. J Am Heart Assoc. 2016 Oct 17;5(10).
18. Fu Q, Zhao M, Wang D, Hu H, Guo C, Chen W, Li Q, *Lemin Zheng, *Chen B. Coronary Plaque Characterization Assessed by Optical Coherence Tomography and Plasma Trimethylamine-N-oxide Levels in Patients with Coronary Artery Disease. American Journal of Cardiology. 2016 Nov 1;118(9):1311-1315.
19. Pan B, Kong J, Jin J, Kong J, He Y, Dong S, Ji L, Liu D, He D, Kong L, Jin D, Willard B, Pennathur S, *Lemin Zheng. A Novel Anti-inflammatory Mechanism of High Density Lipoprotein Through Up-regulating Annexin A1 in Vascular Endothelial Cells. BBA-Molecular and Cell Biology of Lipids. 2016 Jun;1861(6):501-12.
20. Wang Y, Zhou XM, Ma X, Du Y, Lemin Zheng, Liu P. Construction of Nanodroplet/Adiposome and Artificial Lipid Droplets. ACS Nano.2016 Mar 22;10(3):3312-22.
21. Huang X, He D, Ming J, He Y, Zhou C, Ren H, He X, Wang C, Jin J, Ji L, Willard B, *Pan B, *Lemin Zheng. High-density lipoprotein of patients with breast cancer complicated with type 2 diabetes mellitus promotes cancer cells adhesion to vascular endothelium via ICAM-1 and VCAM-1 upregulation. Breast Cancer Res Treat. 2016 Feb;155(3):441-55.
22. Zu L, Ren C, Pan B, Zhou B, Zhou E, Niu C, Wang X, Zhao M, Gao W, *Guo Lijun, *Lemin Zheng. Endothelial microparticles after antihypertensive and lipid-lowering therapy inhibit the adhesion of monocytes to endothelial cells.International Journal of Cardiology. 2015 Oct 9;202:756-759.
23. Li X, Gu F, Niu C, Wang Y, Liu Z, Li N, Pan B, He D, Kong J, Zhang S, Wang X, *Yao Y, *Lemin Zheng. VEGF111b, a C-terminal splice variant of VEGF-A and induced by mitomycin C, inhibits ovarian cancer growth. J Transl Med. 2015 May 20;13:164.
24. Peng M, Li H, Luo Z, Kong J, Wan Y, *Lemin Zheng, Zhang Q, Niu H, Vermorken A, Ven W, Chen C, Zhang X, Li F, Guo L, *Cui Y. Dextran-coated superparamagnetic nanoparticles as potential cancer drug carriers in vivo. Nanoscale. 2015 Jul 7;7(25):11155-62.
25. Shen H, Zhou E, Wei X, Fu Z, Niu C, Li Y, Pan B, Mathew AV, Wang X, Pennathur S, *Lemin Zheng, *Wang Y. High density lipoprotein promotes proliferation of adipose-derived stem cells via S1P1 receptor and Akt, ERK1/2 signal pathways. Stem Cell Research & Therapy. 2015 May 15;6:95.
26. Huang L, Niu C, Willard B, Zhao W, Liu L, He W, Wu T, Yang S, Feng S, *Mu Y, *Lemin Zheng, *Li K. Proteomic analysis of porcine mesenchymal stem cells derived from bone marrow and umbilical cord: Implication of the proteins involved in the higher migration capability of bone marrow mesenchymal stem cell. Stem Cell Research & Therapy. 2015 Apr 15;6:77.
27. Tong X, Lv P, Mathew AV, Liu D, Niu C, Wang Y, Ji L, Li J, Fu Z, Pan B, Pennathur S, *Lemin Zheng, *Huang Y. The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. Cardiovasc Diabetol. 2014 Apr 21;13(1):82.
28. Pan B, Yu B, Ren H, Willard B, Pan L, Zu L, Shen X, Ma Y, Li X, Niu C, Kong J, Kang S, Chen Y. E, Pennathur S, *Lemin Zheng. High Density Lipoprotein (HDL) Nitration and Chlorination Catalyzed by Myeloperoxidase Impairs Its Effects in Promoting Endothelial Repair. Free Radical Biology & Medicine. 2013 Jul;60:272-81.
29. Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, *Lemin Zheng, Sun W*, YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Molecular Cancer. 2014 Jan 13;13:7.
30. Tong X, Peng H, Liu D, Ji L, Niu C, Ren J, Pan B, Hu J, *Lemin Zheng, *Huang Y. High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. Cardiovasc Diabetol. 2013 Jan 30;12(1):27.
31. Dong S, Kong J, Kong F, Kong J, Gao J, Ke S, Wang S, Ding X, *Sun W, and *Lemin Zheng. Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways. Journal of Translational Medicine. 2013 Oct 29;11(1):273.
32. Pan B, Ren H, He Y, Lv X, Ma Y, Li J, Huang L, Yu B, Kong J, Niu C, Zhang Y, Sun WB, *Lemin Zheng. HDL of Patients with Type 2 Diabetes Mellitus Elevates the Capability of Promoting Breast Cancer Metastasis. Clin Cancer Res. 2012 Mar 1;18(5):1246-56.
33. Pan B, Ren H, Lv X, Zhao Y, Yu B, He Y, Ma Y, Niu C, Kong J, Yu F, Sun W, Zhang Y, Willard B, *Lemin Zheng. Hypochlorite-oxidized HDL Elevates its Capability of Promoting Breast Cancer Metastasis. Journal of Translational Medicine. 2012 Mar 30;10:65.
34. Liu D, Ji L, Zhang D, Tong X, Pan B, Liu P, Zhang Y, Huang Y, Su J, *Willard B, *Lemin Zheng. Nonenzymatic glycation of HDL impairs its anti-inflammatory effects in innate immunity. Diabetes Metab Res Rev. 2012 Feb;28(2):186-95.
35. Pan B, Ren H, Ma Y, Liu D, Yu B, Ji L, Pan L, Li J, Yang L, Lv X, Shen X, Chen B, Zhang Y, Willard B, *He Y, *Lemin Zheng. HDL of patients with type 2 diabetes mellitus elevates the capability of promoting migration and invasion of breast cancer cells. Int J Cancer. 2012 Jul 1;131(1):70-82.
36. Liu D, Ji L, Tong X, Pan B, Han JY, Huang Y, Chen YE, Pennathur S, Zhang Y, *Lemin Zheng. Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. Am J Physiol Cell Physiol. 2011 Sep;301(3):C739-48.
37. Peng DQ, Brubaker G, Wu Z, Lemin Zheng, Willard B, Kinter M, Hazen SL, Smith JD. Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated Loss of Function. Arterioscler Thromb Vasc Biol.2008; 28(11):2063-70.
38. Wu Z, Wagner M, Lemin Zheng, Parks J, Shy J, Smith J, Gogonea V, Hazen S. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nature Structural & Molecular Biology.2007 Sep;14(9):861-8.
39. Lemin Zheng, Settle M, Brubaker G, Schmitt D, Hazen S, Smith J, Kinter M. Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages. Journal of Biological Chemistry.2005 Jan 7;280(1):38-47.
40. Lemin Zheng, Nukuna B, Brennan M, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox P, Ischiropoulos H, Smith J, Kinter M, and Hazen S. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. Journal of Clinical Investigation. 2004 Aug;114(4):529-41.