薛言学，北京大学中国药物依赖性研究所副研究员，博士生导师
国家自然科学基金优秀青年基金获得者，中组部****青年拔尖人才
联系方式
办公地址：北京大学中国药物依赖性研究所
电话：-520
Email：yanxuexue@bjmu.edu.cn
简介
薛言学，北京大学中国药物依赖性研究所副研究员，中组部****青年拔尖人才，国家自然科学学基金委优秀青年基金获得者，北京大学博雅青年学者，北京大学中国药物依赖性研究所重点室副主任。主要从事情绪记忆及相关精神障碍的发病机制研究，发表SCI期刊发表论文40余篇，总引用1500余次，其中以第一作者或者通讯作者在Science、JAMA Psychiatry、Molecular Psychiatry、Nature Communications、Biological Psychiatry、Neuropsychopharmacology、The Journal of Neuroscience等SCI期刊发表论文13篇，单篇最高引用360余次，研究发现相继被Science、JAMA Psychiatry等杂志专评，认为其研究发现为成瘾治疗提供了新途径，是向物质成瘾治疗迈出的标志性一步。任中国神经科学会应激神经生物学分会委员，中国毒理学会药物依赖性专业委员会委员、中国研究型医院学会脑研究及转化专业委员会委员等。研究先后得到国家自然科学基金，973项目青年科学家专题、北京市自然科学基金等资助。
主要研究兴趣和方向
1. 应用光遗传学、神经环路追踪、记忆痕迹标记等技术手段，探索异常记忆（如成瘾记忆和创伤性记忆）的存储、去稳定化及消除的分子及环路机制
2. 采用人体和动物行为学范式，综合心理学、sEEG、神经计算、分子生物学等技术，理解情绪（如同情心、抑郁、焦虑、恐惧等）的心理学基础和神经编码机制
代表性论著
1. Han Y, Sun CY, Meng SQ, Tabarak S, Yuan K, Cao L, Yan W, Xu LZ, Deng JH, Zhu WL, Li JL, Lu L*, Xue YX*, Shi J*. Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects. Mol Psychiatry. 2019 Aug 2. IF: 11.973
2. Chen YY, Zhang LB, Li Y, Meng SQ, Gong YM, Lu L, Xue YX*, Shi J*. Post-retrieval Extinction Prevents Reconsolidation of Methamphetamine Memory Traces and Subsequent Reinstatement of Methamphetamine Seeking. Front Mol Neurosci. 2019 Jul 2;12:157. IF: 3.72
3. Huang X, Chen YY , Shen Y , Cao X, Li A , Liu Q , Li Z , Zhang LB ,Dai W , Tan T , O Arias-Carrion*, Xue YX*, Su H* and Yuan TF* . Methamphetamine abuse impairs motor cortical plasticity and Function. Mol Psychiatry. 2017, 22(9):1274-1281. IF: 13.204
4. Xue YX,Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L. Selective inhibition of amygdala neuronal ensembles encoding nicotine-associated memories inhibits nicotine preference and relapse. Biol Psychiatry. 2017 [Epub ahead of print]. IF: 11.412
5. Xue YX^#, Deng JH^#, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of selective inhibition of reactivated nicotine-associated memories with propranolol on nicotine craving. JAMA Psychiatry. 2017, 74(3):224-232.IF: 15.307
6. Zhang Y^#, Xue Y^#, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J. Inhibition of lactate transport erases drug memory and prevents drug relapse. Biol Psychiatry. 2016, 79(11):928-39. IF: 11.412
7. Zhu ZZ^#, Xue YX^#, Han HB, Liu JF, Meng SQ, Chen C, Yang JL, Wu P, Lu L. Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory. Neuropsychopharmacology. 2015, 40(10):2487. IF: 6.403
8. Luo YX^#, Xue YX^#, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L.A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015, 6:7675. IF: 11.329
9. Liu J, Zhao L, Xue Y, Shi J, Suo L, Luo Y, Chai B, Yang C, Fang Q, Zhang Y, Bao Y, Pickens CL, Lu L. An unconditioned stimulus retrieval extinction procedure to prevent the return of fear memory. Biol Psychiatry. 2014, 76(11):895-901. IF: 10.255
10. Xue YX^#, Xue LF^#, Liu JF, He J, Deng JH, Sun SC, Han HB, Luo YX, Xu LZ, Wu P, Lu L. Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. J Neurosci. 2014 May 7;34(19):6647-58. IF: 6.344
11. Chai N^#, Liu JF^#, Xue YX^#, Yang C, Yan W, Wang HM, Luo YX, Shi HS, Wang JS, Bao YP, Meng SQ, Ding ZB, Wang XY, Lu L. Delayed noradrenergic activation in the dorsal hippocampus promotes the long-term persistence of extinguished fear. Neuropsychopharmacology. 2014, 39(8):1933-45. IF: 7.048
12. Ren ZY^#, Liu MM^#, Xue YX^#, Ding ZB, Xue LF, Zhai SD, Lu L.A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology. 2013, 38(5):778-90. IF: 7.833
13. Xue YX^#, Luo YX^#, Wu P^#, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L.A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012, 336(6078):241-5. IF: 31.02
14. He YY^#, Xue YX^#, Wang JS, Fang Q, Liu JF, Xue LF, Lu L. PKMζ maintains drug reward and aversion memory in the basolateral amygdala and extinction memory in the infralimbic cortex. Neuropsychopharmacology. 2011, 36(10):1972-81. IF: 7.991
15. Li FQ^#, Xue YX^#, Wang JS, Fang Q, Li YQ, Zhu WL, He YY, Liu JF, Xue LF, Shaham Y, Lu L. Basolateral amygdala cdk5 activity mediates consolidation and reconsolidation of memories for cocaine cues. J Neurosci. 2010, 30(31):10351-9. IF: 7.271