周岳 邮箱：yue_zhou@pku.edu.cn
研究领域：植物表观遗传学、植物开花以及发育调控。



简介 　　周岳，研究员，博士生导师。2003年毕业于兰州大学生物科学专业。博士期间，以访问学生身份在北京生命科学研究所工作，2010年获得兰州大学细胞生物学博士学位。博士毕业后留在北京生命科学研究所从事博士后研究。2011年至2012年在美国梅奥医学中心进行博士后工作。2012年至2018年在德国马克斯普朗克植物育种学研究所继续以博士后和博士后研究员身份工作。2018年任北京大学现代农学院研究员，同时加入北京大学-清华大学生命科学联合中心。主要的研究工作包括两个方面：1）植物表观遗传学；2）植物开花以及发育调控。研究的植物类群主要是双子叶植物--拟南芥（十字花科）和单子叶植物--小麦（禾本科）。主要研究结果以第一作者发表在Nature Genetics，Genome Biology, PNAS，Plant Cell，Plant Physiology等刊物上。
　　研究方向：
　　实验室致力于研究表观遗传调控在植物发育和植物对环境的响应中的作用。相对于转录因子，染色质修饰复合物也参与基因表达调控，从而在另一层次上控制基因转录，这种多层次的调控存在于植物生长周期的所有重要阶段。然而，这些表观遗传修饰的功能和分子机制尚不清楚。本实验室结合跨学科的研究方法，利用遗传学、基因组学、细胞生物学和生物化学等研究手段，重点研究顺式作用元件和反式作用因子如何调控组蛋白甲基化修饰复合物识别、修饰目标基因并且最终影响其转录。也关注染色质状态在植物冷适应过程中（包括春化）对植物基因转录的调控作用。
　　代表性科研论文：
　　1.Zhou, Y., Wang, Y., Krause, K., Dogus, J., Zhang, Y., Turck, F. Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nat Genet50(5):638-644, doi:10.1038/s41588-018-0109-9 (2018).
　　2.Cui H*., Qiu J*., Zhou Y., Bhandari D.D., Zhao C., Bautor J., and Parker
　　J.E. Antagonism of transcription factor MYC2 by EDS1/PAD4 complexes bolsters salicylic acid defense in Arabidopsis effector-triggered immunity. Mol. Plant 11(8):1053-1066, doi: 10.1016/j.molp.2018.05.007 (2018).
　　3.Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., Velikkakam James, G., Schneeberger, K., and Turck, F. Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A114, 4833-4838, doi:10.1073/pnas. (2017).
　　4.Zhou, Y*., Romero-Campero, F.J*., Gomez-Zambrano, A., Turck, F., and Calonje, M. H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol18, 69, doi:10.1186/s13059-017-1197-z (2017).
　　5.Merini, W., Romero-Campero, F.J., Gomez-Zambrano, A., Zhou, Y., Turck, F., and Calonje, M.. The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development. Plant physiology173, 627-641, doi:10.1104/pp.16.01259 (2017).
　　6.Zhou, Y., Hartwig, B., James, G. V., Schneeberger, K. & Turck, F. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. The Plant Cell28, 87-101, doi:10.1105/tpc.15.00787 (2016).
　　7.Zhou, Y., Zhang, J., Lin, H., Guo, G. & Guo, Y. MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. Plant physiology 154, 1272-1280, doi:10.1104/pp.110.162131 (2010).
　　8.Zhou, Y., Yang, Z., Guo, G. & Guo, Y. Microfilament dynamics is required for root growth under alkaline stress in Arabidopsis. Journal of integrative plant biology52, 952-958, doi:10.1111/j.1744-7909.2010.00981.x (2010).
　　Yue Zhou
　　Email: Yue_Zhou@pku.edu.cn
　　Research Area:
　　My overarching researchinterests focus on the role of epigenetic regulation in plant development and plant-environment responses. In addition to transcription factors, chromatin modifier complexes are also involved in gene regulation, and thereby provide another layer of gene transcription control. However, the function and molecular mechanisms underlying these epigenetic processes are poorly understood. We use a combinedgenetics, genomics, cell biology and biochemistry approaches to study how cis-elements and trans-acting factors cooperate to regulate chromatin modifications, gene transcription and ultimately plant development. We are also interested in the process of how chromatin status affects gene regulation under cold conditions (especially vernalization).
　　Selected Publications:
　　1.Zhou, Y., Wang, Y., Krause, K., Dogus, J., Zhang, Y., Turck, F. Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nat Genet50(5):638-644, doi:10.1038/s41588-018-0109-9 (2018).
　　2.Cui H*., Qiu J*., Zhou Y., Bhandari D.D., Zhao C., Bautor J., and ParkerJ.E. Antagonism of transcription factor MYC2 by EDS1/PAD4 complexes bolsters salicylic acid defense in Arabidopsis effector-triggered immunity. Mol. Plant 11(8):1053-1066, doi: 10.1016/j.molp.2018.05.007 (2018).
　　3.Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., Velikkakam James, G., Schneeberger, K., and Turck, F. Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A114, 4833-4838, doi:10.1073/pnas. (2017).
　　4.Zhou, Y*., Romero-Campero, F.J*., Gomez-Zambrano, A., Turck, F., and Calonje, M. H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol18, 69, doi:10.1186/s13059-017-1197-z (2017).
　　5.Merini, W., Romero-Campero, F.J., Gomez-Zambrano, A., Zhou, Y., Turck, F., and Calonje, M.. The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development. Plant physiology173, 627-641, doi:10.1104/pp.16.01259 (2017).
　　6.Zhou, Y., Hartwig, B., James, G. V., Schneeberger, K. & Turck, F. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. The Plant Cell28, 87-101, doi:10.1105/tpc.15.00787 (2016).
　　7.Zhou, Y., Zhang, J., Lin, H., Guo, G. & Guo, Y. MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. Plant physiology 154, 1272-1280, doi:10.1104/pp.110.162131 (2010).
　　8.Zhou, Y., Yang, Z., Guo, G. & Guo, Y. Microfilament dynamics is required for root growth under alkaline stress in Arabidopsis. Journal of integrative plant biology52, 952-958, doi:10.1111/j.1744-7909.2010.00981.x (2010).