高卫平

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联系电话：
电子邮箱：gaoweiping@bjmu.edu.cn
个人主页：http://openwetware.org/wiki/Gao_lab

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教育经历:

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2000.09 - 2004.06 北京大学 高分子化学与物理专业博士
1993.09 - 2000.06 青岛化工学院 高分子工程专业本科与硕士
学术简历:

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2018.12 - 至今 北京大学跨学部生物医学工程系研究员，博士生导师
2011.10 - 2018.11 清华大学医学院生物医学工程系研究员，博士生导师
2007.05 - 2011.08 美国杜克大学生物医学工程系博士后
2005.05 - 2007.04 日本京都大学化学研究所博士后
主持、参与项目研究方向：

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高分子/超分子生物材料（Polymeric/Supramolecular Biomaterials）；智能/仿生生物材料(Intelligent/Bioinspired Biomaterials)；蛋白质-高分子偶联物（Protein-Polymer Conjugates）；癌症纳米医学（Cancer nanomedicine）
获得荣誉：

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2017年 清华大学优秀博士学位论文一等奖导师奖
2016年 拜耳研究员奖
2012年 杨森研究员奖
2007年 中国科协优秀学术论文奖
1996年 化工部科技兴化奖
近5年代表性论文：
22. Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao^* . One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide. Biomater. Sci. 2019, 7, 104-112.
21. Pengyong Li, Mengmeng Sun, Zhikun Xu, Xinyu Liu, Wenguo Zhao, Weiping Gao^*. Site-selective in situ growth-induced self-assembly of protein-polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence imaging. Biomacromolecules 2018, 19, 4472-4479.
20. Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, Weiping Gao^*. Polymerization induced self-assembly of a site-specific interferon a-block copolymer conjugate into micelles with remarkably enhanced pharmacology. J. Am. Chem. Soc. 2018, 140, 10435-10438.
19. Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang, Weiping Gao*. Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer. Theranostics 2018, 8, 2634-2645.
18. Xinyu Liu, Jiawei Sun, Weiping Gao^*. Site-selective protein modification with polymers for advanced biomedical applications. Biomaterials 2018, 178, 413-434.
17. Xinyu Liu, Jin Hu, Jianwen Guo, Guilin Wang, Weiping Gao^*. Temperature-responsive polymer conjugation of interferon-a enhances antitumor efficacy. Acta Polym. Sin. 2018, 1, 90-98.
16. Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo^*, Weiping Gao^*. Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy. J. Control. Release 2017, 264, 66-75.
15. Wenguo Zhao, Jin Hu, Weiping Gao*. Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy. ACS Appl. Mater. Interfaces 2017, 9，23528-23535.
14. Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao*. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces 2017, 9, 10453-10460.
13. Xinyu Liu, Weiping Gao*. In situ growth of self-assembled protein-polymer nanovesicles for enhanced intracellular protein delivery. ACS Appl. Mater. Interfaces 2017, 9, 2023-2028.
12. Guilin Wang, Jin Hu, Weiping Gao^*. Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy. Sci. China Mater. 2017, 60， 563-570.
11. Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao*. In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy. J. Control. Release 2016, 237, 71-77.
10. Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao*. Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy. Biomaterials 2016, 96, 84-92.
9. Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao^*. Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale 2016, 8, 4452-4457.
8. Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao^*. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha. Adv. Mater. 2015, 27, 7320-7324.
7. Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao^*. Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification. Biomaterials 2015, 64, 2-9.
6. Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao^* Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects. Chem. Commun. 2015, 51, 11405-11408.
5. Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao^*. Synthesis of well-defined protein-polymer conjugates for biomedicine. Polymer 2015, 66, A1-A10.
4. Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao^*. Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention. Biomaterials 2015, 47, 13-19.
3. Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti*. In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation. Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437.
2. Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti*. In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics. Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236.
1. Weiping Gao, Yu Bai, Erqiang Chen*, Zichen Li*, Bingyong Han, Wantai Yang, Qifeng Zhou*. Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution. Macromolecules 2006, 39, 4894-4898.

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