陈建国 邮  箱：chenjg@pku.edu.cn
职  称：教授
办公室地址：北京市海淀区颐和园路5号，北京大学，金光生命科学大楼，100871
实验室地址：北京市海淀区颐和园路5号，北京大学，金光生命科学大楼，100871


个人简介
科研领域
代表性论文
实验室简介
教育经历:1982 - 1985　　研究生　 浙江农业大学
1989 - 1994　　研究生　 北京大学生命科学学院
1997 - 1999　　交换学生 东京大学医学部

荣誉奖励:国家级教学成果奖二等奖 , 2005
北京市级高等教育教学成果奖一等奖 , 2004
全国高校精品课（细胞生物学） , 2003
北京市级高等教育教学成果奖二等奖 , 2001
北京市级高等教育教学成果奖二等奖 , 1997
国家杰出青年科学基金 , 1995工作经历:1999 - 至今 , 教授 , 北京大学生命科学学院
1999 - 2000 , 访问学者 , 香港科技大学生物学系
1997 - 1999 , 访问学者 , 东京大学医学部
1994 - 1999 , 副教授 , 北京大学生命科学学院
1985 - 1989 , 讲师 , 浙江农业大学生物技术中心 学术任职:中国细胞生物学会继续教学工作委员会主任，北京市细胞生物学会副理事长，杂志编辑:北京大学学报 , 2005 - 至今国际老年医学杂志，2015 - 至今执教课程:细胞生物学 , 主持人 , 北京大学 , 1994-2013 秋季学期
本实验室主要兴趣在于：
　　细胞骨架的结构与功能
　　神经系统的发育及细胞分化
　　细胞内膜系统

1.Shen Birong, Pengli Zheng, Nannan Qian, Qingzhou Chen, Xin zhou, Junjie Hu, Jianguo Chen and Junlin Teng. Calumenin-1 Interacts with Climp63 to Cooperatively Determine the Luminal Width and Distribution of Endoplasmic Reticulum Sheets. iScience. 2019. https://doi.org/10.1016/j.isci.2019.10.067
2.Wang Tianning, Yuhong Zou, Ning Huang, Junlin Teng, and Jianguo Chen. CCDC84 acetylation oscillation regulates centrosome duplication by modulating HsSAS-6 degradation. Cell Reports. 2019. 29: 2078-2091. https://doi.org/10.1016/j.celrep.2019.10.028
3.Zhou H, Zheng T, Wang T, Li Q, Wang F, Liang X, Chen J* & Teng J*. CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment. BMC Biol. 2019. https://doi.org/10.1186/s12915-019-0694-9.
4.Tian Xiaoyu, Pengli Zheng, Chenqian Zhou, Xurui Wang, Hua Ma, Wei Ma, Xiaokai Zhou Junlin Teng & Jianguo Chen. DIPK2A Promotes STX17 and VAMP7-mediated Autophagosome-lysosome Fusion by Binding to VAMP7B. Autophagy. https://doi.org/10.1080/**.2019.**
5.Chen Qingzhou, Ya Xiao, Peiyuan Chai, Pengli Zheng, Junlin Teng and Jianguo Chen. 2019. ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy. Current Biology. 29:846-855. https://doi.org/10.1016/j.cub.2019.01.041
6.Huang Ning, Donghui Zhang, Song Wang, Junlin Teng & Jianguo Chen. 2018. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating the localization of CP110-CEP97 complex at the mother centriole. Nature Communications. 2018. 9:4511. DOI: 10.1038/s41467-018-06990-9.
7.Zheng Pengli, qingzhou chen, Xiaoyu Tian, nannan Qian, peiyuan Chai, bing liu, Junjie Hu, Craig Blackstone, Desheng Zhu, Junlin Teng & Jianguo Chen. 2018. DNA Damage Triggers Tubular Endoplasmic Reticulum Extension to Promote Apoptosis by Facilitating ER-mitochondria Signaling. Cell Research. 28:833–854; https://doi.org/10.1038/s41422- 018-0065-z
8.Huang Ning, Yuqing Xia, Donghui Zhang, Song Wang, Yitian Bao1, Runsheng He, Junlin Teng & Jianguo Chen. 2017. Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. Nature Communications. | 8:15057 | DOI: 10.1038/ncomms15057
9.Zhou Haining, Tianning Wang, Tao Zheng, Junlin Teng, Jianguo Chen. 2016. Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nature Communications 7, doi:10.1038/ncomms10151
10.Chen Liang, Sizheng Xu, Yiwei Xu, Weiwei Lu, Lin Liu, Di Yue, Junlin Teng* & Jianguo Chen*. 2016. Cab45S Promotes Cell Proliferation throughSERCA2b Inhibition and Ca2+ Signaling. Oncogene. 35: 35-46.
11.He Runsheng, Huang Ning, Bao Yitian, Zhou Haining, Teng Junlin and Chen Jianguo. 2013. LRRC45 is a Centrosome Linker Component Required for Centrosome Cohesion. Cell Reports. 4:1100-1107.
12.Wang Jingjing, Shan Chunyan, Cao Wenyuan, Zhang Chen, Teng Junlin*, Chen Jianguo*. 2013. SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its anterograde trafficking. Hum. Mol. Genet. 22(24): 4888-4900.
13.Miao Linqing, Teng Junling , Lin Jiqiang, Liao Xianzhi, and Chen Jianguo. 2013. 14-3-3 protein interact with neurofilament protein-L and regulate dynamic assembly of neurofilament. J Cell Sci. 126:427-436.
14.Wu Qixi, He Runsheng, Zhou Haining, Yu CH Albert, Zhang Bo, Teng Junlin and Chen Jianguo. 2012. Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity. Cell Res. 22（9）：1390-1401.
15.Wang Qiao, Teng Junlin, Shen Birong, Zhang Wei, Guo Yige, Su Xiaolei，Zhang Chuanxi, Yu Albert CH, Chen Jianguo. 2010. Characterization of Kinesin-like Proteins in Silkworm Posterior Silkgland Cells. Cell Res. 20: 713-727
16.Li Huihui, Yan Guo, Junlin Teng, Mingxiao Ding, Albert Cheung Hoi Yu and Jianguo Chen. 2006. 14-3-3gamma affects dynamics and integrity of glial filaments by binding to phosphorylated GFAP. J of Cell Science. 119: 4452-4461
17.Chen, J., Nakata, T., Zhang, Z. and Hirokawa, N. 2000. The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. Journal of Cell Science 113, 3861-3869.
18.Chen, J., Kanai, Y., Cowan, N. J. and Hirokawa, N. (1992). Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature. 360, 674 - 677.
我们致力于细胞增殖、分化，以及个体发育过程中细胞结构与功能的动态变化及其调控机制等方面的研究。特别关注细胞骨架对细胞极性化形态结构以及生命活动过程的组织作用；神经系统的发育与细胞分化；细胞内膜系统的动态行为与信号转导、肿瘤细胞的增殖、细胞自噬和细胞凋亡等的关系。