范六民 邮  箱：lmfan@pku.edu.cn
职  称：教授
办公室地址：北京市海淀区颐和园路5号，北京大学，王克桢楼，100871
实验室地址：北京市海淀区颐和园路5号，北京大学，王克桢楼，100871


个人简介
科研领域
代表性论文
教育经历:2001 - 2004 , 博士后 , 植物信号转导 , Pennsylvania State University
1997 - 1999 , 博士后 , 植物信号转导 , 中国农业大学
1994 - 1997 , 理学博士 , 生物系 , 武汉大学生命科学学院
1989 - 1992 , 理学硕士 , 植物学专业 , 北京大学生物系
1985 - 1989 , 理学学士 , 生物系 , 河南师范大学
荣誉奖励:教育部新世纪优秀人才支持计划 , 2004
工作经历:2009 - 至今 , 教授 , 北京大学生命科学学院
2004 - 2009 , 副教授 , 北京大学生命科学学院
1999 - 2004 , 副教授 , 中国农业大学 社会服务工作:教育部新世纪优秀人才支持计划 , 2004
杂志任职:1. 2006 - 至今，Environmental and Experimental Botany编委。2. 2010 - 至今，植物生理学报编委。杂志编辑:Editorial Board , Environmental and Experimental Botany , 2006 - 至今编委 , 植物生理学报, 2010 - 至今执教课程:遗传学讨论课（本科生）
植物激素（研究生）
1、植物干旱和高盐反应的分子基础
2、植物胁迫响应中植物激素的交互作用
　　逆境是影响植物生长发育的主要环境因子。逆境信号转导中脱落酸起非常重要的作用。我们以拟南芥和水稻作为模式植物进行逆境及脱落酸信号转导途径中关键因子的发掘，研究它们的生物学功能及其与农艺形状的关系。另外一个研究重点是，用遗传学、生物化学和分子遗传学方法揭示植物发育及逆境中脱落酸与其它激素信号之间的交互作用。
1. Yang B, Song Z, Li C, Jiang J, Zhou Y, Wang R, Wang Q, Ni C, Liang Q, Chen H, Fan LM. (2018)
RSM1, an Arabidopsis MYB protein, interacts with HY5/HYH to modulate seed germination and seedling development in response to abscisic acid and salinity. PLoS Genet 14(12): e**.
2.Liang L, Yang J, Gao Z, Wang Q, Liang Q, Song Z, Bi Y, Li C, He H, Fan LM. (2018) SPINDLY is involved in ABA signaling bypassing the PYR/PYLs/RCARsmediated pathway and partly through functional ABAR. Environ Exp Bot 151: 43-54.
3. Lin F, Jiang Y, Li J, Yan T, Fan L, Liang J, Chen ZJ, Xu D, Deng XW. (2018) B-BOX DOMAIN PROTEIN28 negatively regulates photomorphogenesis by repressing the activity of transcription factor HY5 and undergoes COP1-mediated degradation. Plant Cell 30(9): 2006-2019.
4. Lin F, Xu D, Jiang Y, Chen H, Fan L, Holm M, Deng XW. (2017) Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis.Proc Natl Acad Sci U S A 114(25): 6617-6622.
5. Li K, Yu R, Fan LM, Wei N, Chen H, Deng XW.(2016) DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis. Nat Commun 7: 11868.
6. Yang M, Wang X, Huang H, Ren D, Su Y, Zhu P, Zhu D, Fan L, Chen L, He G, Deng XW. (2016) Natural variation of H3K27me3 modification in two Arabidopsis accessions and their hybrid.J Integr Plant Biol 58(5): 466-474.
7. Li C, Zhou Y, Fan LM. (2015) A novel repressor of floral transition, MEE3, an abiotic stress regulated protein, functions as an activator of FLC by binding to its promoter in Arabidopsis. Environ Exp Bot 113: 1-10.
8. Li K, Gao Z, He H, Terzaghi W, Fan LM, Deng XW, Chen H. (2015) Arabidopsis DET1 represses photomorphogenesis in part by negatively regulating DELLA protein abundance in darkness. Mol Plant 8: 622-630.
9. Li C, Ng CKY, Fan LM. (2015) MYB transcription factors, active players in abiotic stress signaling. Environ Exp Bot 114: 80-91.
10. Qiao W, Li C, Fan LM. (2014) Cross-talk between nitric oxide and hydrogen peroxide in plant responses to abiotic stresses. Environ Exp Bot 100: 84-93.
11. Feng X, Peng ZY, Fu X, Zhang H, Li S, Deng XW, Fan LM. (2012) Similarity and distinction between organ-specific gibberellin-modulated genome Expression between Arabidopsis and rice. Environ Exp Bot 78:127-137.
12. Qiao W, Fan LM. (2011) Epigenetics, a mode for plants to respond to abiotic stresses. Front Biol 6: 477–481.
13. Chen H, He H, Zou Y, Chen W, Yu R, Liu X, Yang Y, Gao YM, Xu JL, Fan LM, Li Y, Li ZK, Deng XW. (2011) Development and application of a set of breeder-friendly SNP markers for genetic analyses and molecular breeding of rice (Oryza sativa L.). Theor Appl Gene 123: 869-879.
14. Bai S, Zhao J, Zhang Y, Huang W, Xu S, Chen H, Fan LM, Chen Y, Deng XW. Rapid and reliable detection of 11 food-borne pathogens using thin-film biosensor chips. Appl Microbiol Biotechnol 2010, 86: 983-990.
15. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, Deng XW. Biochemical Insights on Degradation of Arabidopsis DELLA Proteins Gained From a Cell-Free Assay System. Plant Cell 2009, 21: 2378-2390.
16. Zhang W, Fan LM. (2009) Actin dynamics regulates voltage-dependent calcium-permeable channels of the Vicia faba guard cell plasma membrane. J Integr Plant Biol 51: 912-921.
16. Qiao W, Xiao S, Yu L, Fan LM. (2009) Expression of a rice gene OsNOA1 re-establishes nitric oxide synthesis and stress-related gene expression for salt tolerance in Arabidopsis nitric oxide-associated 1 mutant Atnoa1. Environ Exp Bot 65:90-98.
18. Fan LM, Zhang W (contributed equally), Chen JG, Taylor JP, Jones AM, Assmann SM. (2008) Abscisic acid regulation of guard-cell K+ and anion channels in Gβ and RGS-deficient Arabidopsis lines. PNAS 105: 8476-8481.
19. Qiao W, Fan LM. (2008) Nitric oxide signaling in plant responses to abiotic stresses. J Integr Plant Biol 50: 1238-1246.
20. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Sch?fer E, Fu X, Fan LM, Deng XW. (2008) Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature 451: 475-479.
21. Ding L, Fan LM, Assmann SM. (2007) pgd1, an Arabidopsis thaliana deletion mutant, is defective in pollen germination. Sex Plant Reprod 20: 137-149.
22. Fan LM (corresponding author), Feng X, Wang Y, Deng XW (corresponding author). (2007) Gibberellin signal transduction in rice. J Integr Plant Biol 49: 731-741.
23. Zhou J, Wang X, Jiao Y, Qin Y, Liu X, He K, Chen C, Ma L, Wang J, Xiong L, Zhang Q, Fan LM, Deng XW. (2007) Rice employs largely organ-specific programs in regulation of genome expression in response to drought and high-salinity stresses. Plant Mol Biol 63: 591-608.
24. Zhang W, Fan LM, Wu WH. (2007) Osmo-sensitive stretch-activated calcium channels in Vicia faba guard cells are regulated by actin dynamics. Plant Physiol 143: 1140-1151.
25. Bai SL, Zhong X, Ma L, Zheng W, Fan LM, Wei N, Deng XW. (2007) A simple and reliable assay for detecting specific nucleotide sequence variations in plants using optical thin-film biosensor chips. Plant J 49: 354-366.
26. Fan LM, Zhao ZX, Assmann SM. (2004) Guard cells: a dynamic signaling model. Curr Opin Plant Biol 7: 537-546.
27. Wang YF, Fan LM, Zhang WZ, Zhang W, Wu WH. (2004) Ca2+-permeable channels in the plasma membrane of Arabidopsis pollen protoplasts are regulated by actin microfilaments. Plant Physiol 136: 3892-3904.
28. Coursol S*, Fan LM* (* contributed equally), Le Stunff H, Gilroy S, Speigel S, Assmann SM. (2003) Sphingolipid signalling in guard cells involves G proteins. Nature 423:651-654.
29. Fan LM, Wang YF, Wang H, Wu WH. (2003) Outward K+ channels in Brassica chinensis pollen protoplasts are regulated by external and internal pH. Protoplasma 220:143-152.
30. Fan LM, Wang YF, Wang H, Wu WH. (2001) In vitro Arabidopsis pollen germination and characterization of the inward potassium currents in Arabidopsis pollen grain protoplasts. J Exp Bot 52: 1603-1614.
31. Fan LM, Wu WH. (2000) External pH regulates the inward K+ channels in the plasma membranes of Brassica pollen protoplasts. Prog Nat Sci 10: 68-73.
32. Fan LM, Wu WH, Yang HY. (1999) Identification and characterization of the K+ inward currents in the plasma membranes of Brassica pollen protoplasts. Plant Cell Physiol 40: 859-865.