徐成冉 邮  箱：cxu@pku.edu.cn
职  称：研究员
办公室电话：**
办公室地址：北京市海淀区颐和园路5号，北京大学，吕志和楼，100871
实验室电话：**
实验室地址：北京市海淀区颐和园路5号，北京大学，吕志和楼，100871


个人简介
科研领域
代表性论文
教育经历:2000 - 2005 , 理学博士 , 植物学 , 北京大学
1995 - 1999 , 理学学士 , 遗传学 , 复旦大学
荣誉奖励:优秀青年科学基金，2015
NIH Career Development Award (K01) , 2012
工作经历:2013 - 至今 , Investigator , Peking University, School of Life Sciences
2012 - 2013 , Research Investigator Senior , University of Pennsylvania, School of Medicine
2009 - 2012 , Research Associate , University of Pennsylvania, School of Medicine
2008 - 2009 , Postdoctoral Associate , Fox Chase Cancer Center
2005 - 2008 , Research Associate , The Scripps Research Institute 执教课程:分子生物学实验室科研技能（本科），主讲，北京大学 , 秋季
发育生物学（ PTN） , 主讲 , 北京大学 , 春季
高级细胞生物学 （本科），讲课，北京大学 , 春季
细胞生物学 （研究生），主讲，北京大学 , 秋季
本实验室主要兴趣：
　　干细胞生物学/再生医学：胚胎干细胞定向分化；组织器官再生。
　　　　发育生物学：哺乳动物肝脏和胰腺发育机理。
　　　　系统生物学：细胞信号、表观遗传对发育和再生过程中基因网络的调控。
　　哺乳动物中肝脏及胰腺相互协调在代谢的过程中发挥关键作用。在胚胎发育的早期，胰腺和肝脏的祖细胞从前肠内胚层的一个多能细胞区域竞争性起源，这个过程受到一些共同的细胞信号和转录因子调控。当肝脏和胰腺的细胞出现损伤和功能紊乱时，就会导致许多代谢疾病（如肝病和糖尿病），严重影响健康。因此如何促进肝脏和胰腺的再生是本领域的重要问题。干细胞研究和肝脏、胰腺发育的调控相结合，将更好地解决这一问题。
　　本实验室长期研究方向主要集中在肝脏及胰腺发育过程中细胞分化，器官建成和再生，主要包括，（1）研究哺乳动物从胚胎发生开始的发育过程中肝实质细胞及内分泌细胞的分化及成熟机制。细胞信号、表观遗传修饰和基因网络协调作用，对这些细胞的分化及成熟过程进行着严格的调控。这些不同层次的调控机制是我们关注的重点。（2）利用获得的肝脏发育过程中的线索指导体外胚胎干细胞分化成成熟的肝实质细胞，用于对肝病进行细胞水平的治疗。（3）将胰腺发育中内分泌细胞分化和成熟过程中获得线索应用于干细胞分化为β细胞的流程，以更好的诱导出有生理功能、成熟的分泌胰岛素的β细胞。（4）通过对肝脏和胰腺发育过程的分子机制研究，结合体外干细胞诱导分化，体外重建有功能的肝脏和胰岛，为再生医疗治疗代谢疾病奠定基础。
*corresponding author; #contribute equally
1. Xin-Xin Yu and Cheng-Ran Xu*, Understanding generation and regeneration of pancreatic β cells from a single-cell perspective (Review). Development (in press), 2020
2. Ye Feng#, Wei-Lin Qiu#, Xin-Xin Yu, Yu Zhang, Mao-Yang He, Weiyi Zhang, Michael Franti, Junqing Ye*, Joerg D. Hoeck* and Cheng-Ran Xu*, Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis. Molecular Metabolism (in press), 2020
3. Xin-Xin Yu#, Wei-Lin Qiu#, Liu Yang, Yu Zhang, Mao-Yang He, Lin-Chen Li and Cheng-Ran Xu*, Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution. The EMBO Journal (2019) e100164
4. Li Yang, Lin-Chen Li, Lamaoqiezhong, Xin Wang, Wei-Hua Wang, Yan-Chun Wang and Cheng-Ran Xu*, The contributions of mesoderm-derived cells in liver development (Review). Seminars in Cell and Developmental Biology, 2018
5.Lin-Chen Li#, Wei-Lin Qiu#, Yu-Wei Zhang, Zi-Ran Xu, Yi-Ni Xiao, Caiying Hou, Lamaoqiezhong, Peng Yu, Xin Cheng and Cheng-Ran Xu*, Single-cell transcriptomic analyses reveal distinct dorsal/ventral pancreatic programs. EMBO reports, 2018
6. Lin-Chen Li#, Xin-Xin Yu#, Yu-Wei Zhang#, Ye Feng, Wei-Lin Qiu and Cheng-Ran Xu*, Single-cell transcriptomic analyses of mouse pancreatic endocrine cells. JoVE, 2018
7. Xin-Xin Yu#, Wei-Lin Qiu#, Liu Yang, Lin-Chen Li, Yu-Wei Zhang and Cheng-Ran Xu*, Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment. Development, 2018, 145(6):doi: 10.1242/dev.163162
8. Wei-Lin Qiu#, Yu-Wei Zhang#, Ye Feng#, Lin-Chen Li, Liu Yang, Cheng-Ran Xu*, Deciphering pancreatic islet β-cell and α-cell maturation pathways and characteristic features at the single-cell level. Cell Metabolism, 2017, 25:1194-1205
9. Li Yang#, Wei-Hua Wang#, Wei-Lin Qiu#, Zhen Guo, Erfei Bi and Cheng-Ran Xu*, A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation. Hepatology, 2017, 66(5):1387-1401
10. Ramkumar Mohan, Yi-Ping Mao, Shun-Gang Zhang, Yu-Wei Zhang, Cheng-Ran Xu, Gérard Gradwohl and Xiao-Qing Tang*. Differentially expressed microRNA-483 confers distinct functions in pancreatic beta- and alpha-cells. Journal of Biological Chemistry, 2015, 32: 19955-19966
11. Cheng-Ran Xu, Lin-Chen Li, Greg Donahue, Lei Ying, Yu-Wei Zhang, Paul Gadue & Kenneth S. Zaret*. Dynamics of Genomic H3K27me3 Domains and Role of EZH2 during Pancreatic Endocrine Specification. The EMBO Journal, 2014, 33: 2157-2170
12. Cheng-Ran Xu & Kenneth S. Zaret*. Chromatin `Pre-Pattern` and Epigenetic Modulation in the Cell Fate Choice of Liver over Pancreas in the Endoderm. Nucleus, 3(2): 150-154 (2012)
13. Cheng-Ran Xu, Philip A. Cole, Jay D. Kormish, Shannon Dent & Kenneth S. Zaret*. Chromatin `Pre-Pattern` and Histone Modifiers in a Fate Choice for Liver and Pancreas. Science, 332: 963-6 (2011)
14. Cheng-Ran Xu & Ann J. Feeney*. The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. Journal of Immunology, 182(3): 1362-9 (2009)
15. Cheng-Ran Xu, Lana Schaffer, Steven R. Head & Ann J. Feeney*. Reciprocal patterns of methylation of H3K27 and H3K36 on proximal vs. distal IgVH genes are modulated by IL7 and Pax5. The Proceedings of the National Academy of Sciences USA (PNAS), 105: 8685-8690 (2008)
16. Cheng-Ran Xu, Cui Liu, Yi-Lan Wang, Lin-Chen Li, Wen-Qian Chen, Zhi-Hong Xu & Shu-Nong Bai*. Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. The Proceedings of the National Academy of Sciences USA (PNAS), 102: 14469-14474 (2005）