佟向军
北京大学生命科学学院副教授
传真:+86-10-62751526联系电话:+86-10-62753077北京市海淀区颐和园路5号，北京大学生命科学学院,北京,中国,邮政编码:100871

个人简历
科研领域描述本实验室主要兴趣在于：

实验室主要兴趣是斑马鱼的胚胎发育。
斑马鱼是研究脊椎动物发育和人类疾病的理想模式生物。随着斑马鱼基因组计划的接近完成，我们面临着研究将近30,000个在斑马鱼和其他脊椎动物都保守的基因的功能及其调控的艰巨任务。大规模的反转录病毒插入诱变技术已在斑马鱼中得到成功地应用，最近，曾经在果蝇中广泛应用的增强子诱捕技术和基因诱捕技术，也在斑马鱼中得以推广。我们实验室目前正在应用大规模增强子诱捕技术、基因诱捕技术和基因组尺度的反转录病毒插入诱变技术，筛选在斑马鱼胚胎发育过程中起重要作用的基因。

ResearchDescription:
Thezebrafishisanexcellentmodelanimaltostudyvertebratedevelopmentandhumandiseases.Withthenearcompletionofitsgenomesequence,wefaceanenormousandimmediatechallengetorevealthefunctionandregulationofapproximately30,000highlyconservedgenescontainedinzebrafishandothervertebrategenomes.Large-scaleretroviralinsertionalgeneticscreenshavebeensuccessfullyappliedtozebrafish.Morerecently,enhancer/genetrapstrategy,apowerfultooloffunctionalgenomicsasshownbysuccessfulworkinDrosophila,hasbeenreportedinzebrafish.Nowweareapplyingthelargescaleenchancer-trapandgene-trapmediatedbyTol2transposonscreenandAGenome-WideMutagenesisScreenMediatedbyRetrovirusInsertioninzebrafish.


代表性论文1.IkezoeT,ChenSS,TongXJ,HeberD,TaguchiH,KoefflerHP,Oridonininducesgrowthinhibitionandapoptosisofavarietyofhumancancercells,IntJOncol.,2012,23(4):1187-93.
2.TongX,XieD,O'KellyJ,MillerCW,Muller-TidowC,KoefflerHP,Cyr61,amemberofCCNfamily,isatumorsuppressorinnon-smallcelllungcancer,JBiolChem.,2012,276(50):47709-14
3.ChenPP,LiWJ,WangY,ZhaoS,LiDY,FengLY,ShiXL,KoefflerHP,TongXJ,andXieD,ExpressionofCyr61,CTGF,andWISP-1correlateswithclinicalfeaturesoflungcancer,PLoSONE,2007,2(6):e534
4.YanWang,Dong-PingLiu,Ping-PingChen,H.PhillipKoeffler,Xiang-JunTong,andDongXie,InvolvementsofIFNRegulatoryFactor-1andIFNRegulatoryFactor-2intheFormationandProgressionofHumanEsophagealCancers,CancerRes.,2007,67:(6)：2535-43
5.KawabataH,TongX,KawanamiT,WanoY,HiroseY,SugaiS,KoefflerHP,Analysesforbindingofthetransferrinfamilyofproteinstothetransferrinreceptor2,BrJHaematol,2004,127(4):464-73
6.TongX,O'KellyJ,XieD,MoriA,LempN,McKennaR,MillerCW,KoefflerHP,Cyr61suppressesthegrowthofnon-small-celllungcancercellsviathebeta-catenin-c-myc-p53pathway,Oncogene,2004,23(28):4847-55
7.XieD,YinD,TongX,O'KellyJ,MoriA,MillerC,BlackK,GuiD,SaidJW,KoefflerHP,Cyr61isoverexpressedingliomasandinvolvedinintegrin-linkedkinase-mediatedAktandbeta-catenin-TCF/Lefsignalingpathways,CancerRes.,2004,64(6):1987-96
8.TongX,XieD,RothW,ReedJ,KoefflerHP,NADE(p75NTR-associatedcelldeathexecutor)suppressescellulargrowthinvivo,IntJOncol.,2003,22(6):1357-62
9.HoffmanWK,TongXJ,AjiokaRS,KushnerJP,KoefflerHP,Mutationanalysisoftransferrin-receptor2inpatientswithatypicalhemochromatosis,Blood,2002,100(3):1099-100
10.TongX,KawabataH,KoefflerHP.,IrondeficiencycanupregulateexpressionoftransferrinreceptoratboththemRNAandproteinlevel,BrJHaematol.,2002,116(2):458-64
11.KawabataH,GermainRS,IkezoeT,TongX,GreenEM,GombartAF,KoefflerHP,Regulationofexpressionofmurinetransferrinreceptor2,Blood,2001,98(6):1949-54
12.JieLiu,XiangjunTong,ShijinPang,ZhongheZhai,Theperiodicityinthestructureofnativeneurofilamentsstudiedwithscanningtunnelingmicroscopy,AppliedSurfaceScience,1999,144-145（1999）644-647
13.佟向军翟中和陈建国,神经丝蛋白NF-L与NF-M杂合分子的表达与组装――中等分子量神经丝蛋白的第一段杆状区是影响装配的结构域,中国科学（C辑）,1999,29（4）：337
14.佟向军陈建国刘洁庞世瑾翟中和,牛脊髓神经丝的体外组装与结构,中国科学（C辑）,1999,29（2）：117-124
15.闵光伟杨澄佟向军翟中和,植物角蛋白中间纤维在体外的装配特性,中国科学(C辑),1999,29(4)367-374
16.JieLiu，XiangjunTong，JianguoChen，ShijinPang，ZhongheZhai,InvestigationontheStructureofNativeNeurofilamentswithScanningTunnelingMicroscopy,ElectronMicrocopySymposiumJJ,1998,VolumeIV：269-270
17.ZhaiZhonghe，TongXiangjun，MinGuangwei，YangCheng，LiuJie,Invitroassemblyofnuclearlamine,keratinintermediatefilamentsandneurofilaments.,ElectronMicroscopySymposiumJJ,1998,VolumeIV：247-248
18.刘洁，佟向军，庞世瑾，翟中和,应用扫描隧道显微镜研究神经丝的结构,科学通报,1998,（43）：18