黄家强 职称：教授
学历：研究生
学位：博士
电话：
邮箱：jqhuang@bjtu.edu.cn




教育背景
工作经历
研究方向
招生专业
科研项目
教学工作
论文/期刊
专著/译著
专利
软件著作权
获奖与荣誉
社会兼职
教育背景
医学博士，1997年 华中科大同济医学院（原同济医科大学)。

工作经历
1993-1994年：华中科大同济医学院基础医学院免疫室，助教;
1997-1999年：北京大学医学部免疫系, 人类基因疾病中心，博士后；
1999-2004年：美国国立健康研究院（NIH），美国国家癌症研究所（NCI）, 分子免疫调节实验室， 访问(1999-2001), 科学家 (2001-2004, Basic Research Program, SAIC-Frederick)；
2004-2006年：美国约翰霍普金斯大学医学院， Faculty member，助理研究员；
2006-2011年： 美国Qiagen-SABiosciences，资深科学家；
2011- ：交通大学理学院生命科学与生物工程研究院， 教授；
2013- ： 美国NCI， Cancer & Inflammation Program, 合作研究员。


研究方向
生物化学与分子生物学
细胞生物学


招生专业
生物学硕士


科研项目


1.交大—诺森项目联合转化研究创新中心（S18L00290）；2018-2028；2，000万元；项目负责人。
2.骨髓锌指1的表观调控在胃癌化疗敏感性中与金属硫蛋白2A相互作用机制。自然科学基金面上（**）；67万；子课题负责。
3.免疫力科研检测（KSL**）；2018-2019；3万元；项目负责人。
4.河南“1125聚才计划”创新创业领军团队；2017-2020；300万元；领军人才，项目负责人。
5.阿尔茨海默病检测试剂盒研发（KSL**）；166万；参与。
6.Funded in part by Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN1E（2013.5- ）。
7.Supported in part by the Intramural Research Program of the NCI, NIH（2013.5-）。
8.耐药结核菌检测方法的研究（KSL**）；2014-2017；50万元；项目负责人。
9.恶性肿瘤发病机制及转化研究教育部重点实验室开放基金:金属硫蛋白2A（MT2A）在胃癌中的表观调控及其功能应用研究(开放-8); 2014-2016；10万元；主持。
10.以生物技术药为主的综合性新药研发技术大平台建设（2013ZX-005）；"重大新药创制”国家科技重大专项；1300.00万元；2013-2015；子课题负责人（680万元）。
11. AMP-18在胃癌中功能机制研究及其临床应用价值（人才基金）; 2012-2015；15万元；主持



教学工作
《遗传学》（本科生);
《表观遗传学》（双语授课）（本科生);
《生命科学纵横》（本科生);
《分子细胞免疫学》（双语授课）（研究生），
1994-1997年 华中科大同济医学院，《免疫学》（研究生），《医学免疫学》（本科生）。
1997-1999年 北京大学, 《医学分子免疫学》（研究生），《医学免疫学》（本科生）。


论文/期刊
参与著书两部，发表综述、论文四十余篇， 单篇影响因子最高为24分，累计引用超过1000次，单篇最高引用超过120次。以第一作者发表在《Journal of Immunology》、《EMBO J.》、《Nuclear Acid Research》上的论文被《 Nature Review of Immunology》、《Faculty of 1000》等专题报导评论。

Selected peer-reviewed publications:

Lin S, Wang X, Pan Y, Tian R, Lin B, Jiang GS, Chen K, He YQ, Zhang L, Zhai W, Jin P, Yang L, Li G, Wu Y, Hu J, Gong W, Chang Z, Sheng JQ, Lu Y, Wang JM, Huang J . Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human GastricCarcinogenesis by Interacting with Metallothionein 2A. Clin Cancer Res. 2018 Oct 9. pii: clincanres.1281.2018. doi: 10.1158/1078-0432.CCR-18-1281. [Epub ahead of print] PubMed PMID: **.
Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, H Badger J, O'hUigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM. The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance. J Immunol. 2018 Mar. 15;200(6):2174-2185.
Wang XF，Chen K, Yu Y，Xiang Y， Kim JH，Gong W，Huang J，Shi S， LiQ，Zhou M，Sayers T, Tewary P, Gao B, and Wang JM. Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib. Oncotarget, 2017, Vol. 8, (No. 65), pp: 109068-109078.
Lin B, Zhou X, Lin S, Wang X, Zhang M, Cao B, Dong Y, Yang S, Wang JM, Guo M, Huang （corresponding author）. Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma. J Mol Med (Berl). 2017; 95 (11): 1237-1249。
Jiao YY, Fu YH, Yan YF, Hua Y, Ma Y, Zhang XJ, Song JD, Peng XL, Huang J, Hong，T, He JS. A single intranasal administration of virus-like particle vaccine induces an efficient protection for mice against human respiratory syncytial virus. Antiviral Res. 2017 Aug; 144:57-69.
Lin S, Lin B, Wang X, Pan Y, Xu Q, He JS, Gong W, Xing R, He Y, Guo L, Lu Y, Wang JM, Huang (corresponding author）. Silencing of ATP4B of ATPase H(+)/K(+) Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. Oncol Res. 2017 Mar 13;25(3):317-329.
Pan Y, Lin S, Xing R, Zhu M, Lin B, Cui J, Li W, Gao J, Shen L, Zhao Y, Guo M, Wang JM, Huang J (corresponding author), Lu Y: Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-kappab activation. Antioxid Redox Signal 2016; 24 (15): 839-854.
Xiang Y, Yao X, Chen K, Wang X, Zhou J, Gong W, Yoshimura T, Huang J, Wang R, Wu Y, Shi G, Bian X, Wang J. The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells. Am J Cancer Res. 2016; 6 (11):2599-2610.
Xing R, Li L, Chen L, Gao Z, Wang H, Li W, Cui J, Tian G, Liang Q, Yu J, Sung JJ, Luo G, Gao H, Xu X, Yang H, Wang J, Zhang X, Wang JM, Huang J, Yu Y, Wang J, Lu Y. Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells. Oncogene. 2016 May 19;35(20):2584-91.
Guo L, Bai H, Zou D, Hong T, Liu J, Huang J, He P, Zhou Q, He J. The role ofmicroRNA-133b and its target gene FSCN1 in gastric cancer. J Exp Clin Cancer Res. 2014 Nov 30;33(1):99.
Chen K, Xiang Y, Huang J, Gong W, Yoshimura T, Jiang Q, Tessarollo L, Le Y, Wang JM. The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation. J Biol Chem. 2014 Jun 20; 289 (25): 17553-63.
Pan Y*, Huang J*, (*Co-first author), Xing R et al. Metallothionein 2A inhibits NF-kappaB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection. J Transl Med. 2013; 11: 173.
Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y. IL-7Rapha deficiency in p53(null) mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. 2012; 19: 1139-51.
Hamano, R., Huang, J., Toshimura, T., Howard, O.M. Z., Oppenheim, J.J., Chen, X. TNF induces co-stimulatory TNF receptor superfamily member TNFR2, 4-1BB andOX40 on CD4+FoxP3+ regulatory T cells. Eur. J. Immunol. 2011; 41: 2010-20.
Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. Proc Natl Acad Sci U S A. 2011; 108: 5626-31.
Huang, J.（corresponding author）, Quellhorst, G.J., Gu, X. Xiang, Y., Zeng, X., Boon., K., An innovative approach for profiling of histone modification marks and gene expression across a panel of oncogenes and tumor suppressor genes in multiple cancer cell lines. Cancer Research 2010 70（8）：Supplement, pp. LB-140.
Song, B. Zeng X., Blanchard, R., Huang J. （corresponding author）. A fast ChIP approach to integrated analysis of epigenetic and transcriptional regulation in multiple cancer cell types. Cancer Research 2009 69（9）： Supplement, pp. 5211.
Huang, J., Chen, K., Huang, J., Gong, W., Dunlop, N.M., Howard, O.M., Bian, X., Gao, Y., Wang, J.M. Regulation of the leukocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis. 2009; 30: 348-55.
Zhu, G., Augustine, M.M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A.C., Huang, J., Xu, H., Flies, A.S., Flies, S.J., Tamada, K., Colonna, M., van Deursen, J.M., Chen, L. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood. 2009; 113:1759-67.
Blanchard, R., Gu, X.,, Huang, J., Burnette,A., and Zeng,X.. Differential p53 binding site occupancy in apoptotic and cell cycle regulating gene promoters across different cancer cell types upon treatment with 5-fluorouracil. Cancer Res., May 2008; 68: 1746.
Jiang, Q., Huang, J., Li, W.Q., Muegge, M., and Durum, S.K. Role of the Intracellular Domain of IL-7 Receptor in T Cell Development. J. Immunol. 2007; 178: 228-234.
Wang, L.H., Yang, X.Y., Zhang, X., An, P., Kim, H., Huang, J., Clarke, R., Osborne, C.K., Inman, J.K., Appella, E., and Farrar, L.W. Disruption of estrogen receptor zinc finger domains and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell. 2006; 10: 487-499.
Huang, J., Fan, T., Yan, Q., Zhu, H., Fox, S., Issaq, H.J., Best, L., Gangi, L., Munroe, D. and Muegge, K. Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res. 2004; 32: 5019-5018.
Wang, L.H., Yang, X.Y., Zhang, X., Huang, J., Mihalic, K., Zhu, H., Xiao, W., Muegge, K., Farrar, L.W. Transcriptional inactivation of STAT3 by PPAR gamma suppresses IL-6-responsive multiple myeloma cells. Immunity. 2004; 20: 205-18.
Yan, Q.*, Huang, J.* (Co-first author), Fan, T., Zhu, H., Muegge, K. Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. EMBO J. 2003; 19: 5154-5162.
Fan, T. Yan, Q., Huang, J., Austin, S., Cho, E., Ferris, D., Muegge, K. Lsh deficient murine embryonic fibroblasts show reduced proliferation with signs of abnormal mitosis. Cancer Research. 2003; 63: 4677-4683.
Khaled, A. R, Li, W. Q., Huang, J., Fry, T. J, Khaled, A. S., Mackall, C. L., Muegge, K., Young, H. A., Durum, S. K. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity. 2002; 17: 561-573.
Huang, J., Durum, S. K., and Muegge, K. Cutting edge: Histone acetylation and recombination at the TCR gamma locus follows IL-7 induction. J. Immunol. 2001; 167: 6073-6077.
Han W, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, Gu W, Huang J, Gui L, Tang Y, Li F, Song Q, Di C, Wang L, Shi Q, Sun R, Xia D, Rui M, Tang J, Ma D. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J. 2001 Jul 1;357(Pt 1):127-35.
Huang, J. & Muegge, K. Control of chromatin accessibility for V(D)J recombination by interleukin 7. J. Leukoc. Biol. 2001; 69:907-11.

















专著/译著
参与编写：
苏娜 沈关心 主编《抗体工程》科学出版社 1996
杨锡强 主编《儿童免疫学》 人民卫生出版社 2001


专利

1.一种复方镇痛药。 Patent No: ZL 94 1 08418.3。 International paten classic No: A61K 31/55.2。
2.Chemokine-like factors (CKLFs) with chemotactic and hematopoietic stimulating activities。International patent classic No: C07K 14/52, C12N 15/19, A61K 38/19。
3.Nucleic acid molecule encoding chemokine-like factor 1 (CKLF1)。United States Patent **。
4.MT2A基因组蛋白乙酰化修饰检测试剂盒及引物对。专利申请号：6。
5.片段化交联DNA的快速分离与检测试剂盒及方法。 专利申请号：5。
6.石蜡包埋组织样本中交联DNA的快速分离与检测的方法。专利申请号20**。
7.一种基于ATP4B基因体DNA的表观修饰检测引物对及试剂盒。专利申请号：7。
8.一种用于肝癌诊断、化疗与预后检测的分子标记物及试剂盒。专利申请号：3.4。
9.用于胃癌诊断、化疗和预后检测的分子组合物及试剂盒。专利申请号：S**。
10.用于胃癌诊断、化疗和预后检测的分子标记物及试剂盒。专利申请号：S**。







软件著作权


获奖与荣誉


社会兼职