汤楠博士北京生命科学研究所研究员
NanTang,Ph.D.
AssistantInvestigator,NIBS,Beijing，China
Phone：86-10-80726688
Fax：86-10-80726689
E-mail：tangnan@nibs.ac.cn
教育经历Education2005年美国加州大学圣地亚哥分校，博士Ph.D.,UniversityofCalifornia,SanDiego,CA,USA1993年西安交通大学，医学学士M.D.,Xi’AnJiaoTongUniversity,Xi’An,P.R.China工作经历ProfessionalExperience2012年-北京生命科学研究所研究员AssistantInvestigator,NationalInstituteofBiologicalSciences,Beijing,China2006-2012美国加州大学旧金山分校解剖发育生物学系，博士后PostdoctoralFellow,Dept.ofAnatomyandPrograminDevelopmentalBiology,UniversityofCalifornia,SanFrancisco,CA,USA2000-2005美国加州大学圣地亚哥分校分子病理学系，博士研究生GraduateResearchAssistantinMolecularPathology,UniversityofCalifornia,SanDiego,CA,USA1998-2000美国加州大学圣地亚哥分校细胞及发育生物学系，博士后研究员PostdoctoralResearcher,CellandDevelopmentalBiology,DivisionofBiologicalSciences,UniversityofCalifornia,SanDiego,CA,USA研究概述ResearchDescription通过诱导自我修复与再生以治疗因疾病、创伤、衰老或遗传因素所造成的器官组织缺损是生物学和现代医学目前面临的重大挑战。我们当前的研究兴趣集中在利用小鼠肺脏作为模型，揭示胚胎发育和组织再生的机理。小鼠的肺气管及支气管发育是一个高度程序化的(stereotyped)过程。在胚胎发育过程中，气管的分支以及上皮细胞的分化受到严格的时空调控，最终形成功能正常的肺脏。本实验室运用遗传学，细胞生物学，器官培养和动态成像等多种手段探索肺气管形态发生和上皮前体细胞命运决定的分子机理。这些机理的揭示对了解肺发育异常及呼吸道疾病有着重要的意义。另外，肾脏，乳腺，胰腺，腮腺，和血管等也都是由分支发育起始最终形成结构复杂和功能各异的器官和组织。因此我们的研究结果将为这些器官和组织的发育以及再生提供理论基础，并有助于找到有效的生物工程方法去构建新的器官与组织。Theresearchgoalofourlaboratoryistounderstandthecellularandmolecularbasisforhowcomplexthree-dimensionaltissuesareestablishedduringvertebrateembryonicdevelopmentandtissueregeneration.Wecurrentlyfocuslargelyonunderstandinglungdevelopment.Lungdevelopsfromepithelialtubesthatbranchintoacomplexnetworkcomprisingtubesofdifferentsizesandshapes.Duringbranchingmorphogenesis,thefatesofepithelialcellsinconductingairways(bronchiandbronchioles)andperipheralgasexchangeregions(alveoli)ofthelungaretightlycontrolledtemporallyandspatiallyinordertopreparefornormallungfunctionatbirth.Byemployingaconvergenceofmousegenetics,cellbiology,organcultureandthree-dimensionaltime-lapseimaging,wewillinvestigatethegeneticandcellularmechanismsthatunderlieairwaybranchingmorphogenesisandairwayepithelialprogenitorcellfatespecification.Knowledgeobtainedfromourstudiesshouldsignificantlyadvanceourunderstandingofrespiratorydisordersandcongenitaldefectsinhumanneonates,andprovideinsightintohowthedisruptionofmorphogeneticprogramsearlyinlungdevelopmentcanleadtodeficienciesthatpersistthroughoutlife.Furthermore,ourstudieswillprovideinformationthatisfundamentalforfuturebioengineeringeffortsaimedatgeneratingafunctionalrespiratoryorgan.发表文章Publications1.TangN,MarshallWF(2011)CentrosomePositioninginVertebrateDevelopment.JCellSciinpress(invitedreview)2.TangN,MarshallWF,McMahonM,MetzgerRJ,MartinGR(2011)ControlofmitoticspindleanglebytheRAS-regulatedERK1/2Pathwaydetermineslungtubeshape.ScienceJul15;333:342-5.PMID:21764747Alsosee“TubularTransformation”(2011),ScienceJul15;333:294-295(2011);“Development:Theepithelialcontortionists”(2011),NatureReviewsMolecularCellBiologySep1;12:5453.ZhengB,TangT,TangN,KudlickaK,OhtsuboK,MaP,MarthJD,FarquharMGandLehtonenE(2006)EssentialroleofRGF-PX1/sortingnexin13inmousedevelopmentandregulationofendocytosisdynamics.PNASNov7;103(45):16776-81.PMID:170771444.TangN,MackF,HaaseVH,SimonMCandJohnsonRS(2006)pVHLfunctionisessentialforendothelialextracellularmatrixdeposition.MolCellBiol.Apr;26(7):2519-30PMID:155424325.MendozaMC,DuF,IranfarN,TangN,MaH,LoomisWFandFirtelRA(2005)LossofSMEK,anovel,conservedprotein,suppressesmek1nullcellpolarity,chemotaxisandgeneexpressiondefects.MolCellBiol.Sep;25(17):7839-53.PMID:161077286.TangN,WangLC,EskoJ,GiodanoF,HuangY,GerberHP,FerraraNandJohnsonRS(2004)LossofHIF-1alphainendothelialcellsdisruptsahypoxia-drivenVEGFautocrineloopnecessaryfortumorigenesis.CancerCellNov;6(5):485-95.PMID:15542432