关键词: 光学相干层析成像/
受激辐射/
抽运探测/
分子特异性
English Abstract
Stimulated-emission based spectral domain optical coherence tomography for molecular contrast imaging
Hu Zhe-Hao,Shangguan Zi-Wei,
Qiu Jian-Rong,
Yang Shan-Shan,
Bao Wen,
Shen Yi,
Li Peng,
Ding Zhi-Hua
1.College of Optical Science and Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, China
Fund Project:Project supported by the National Key Research and Development Program of China (Grant No. 2017YFA0700501), the National Natural Science Foundation of China (Grant Nos. 61335003, 61327007, 11404285, 61475143), and the National High Technology Research and Development Program of China (Grant No. 2015AA020515).Received Date:28 July 2017
Accepted Date:24 May 2018
Published Online:05 September 2018
Abstract:Due to unnoticeable changes in complex refractive index of tissue under varied pathological and physiological states, the traditional optical coherence tomography (OCT) is deficient in molecular characterization. In this paper, the stimulated-emission based optical coherence tomography is proposed, which provides both molecular contrast and scattering contrast OCT imaging simultaneously. Based on the established ultra-high resolution spectral domain OCT system, a pump-probe spectral domain OCT system with a single wide-bandwidth light source is developed through an added modulated pump beam via spectrum splitting. In addition, the theory about the stimulated-emission signal and the image formulation under the modulated pump beam is presented. The coherent detection of the transient stimulated emission is realized by the developed pump-probe spectral domain OCT system. With the stimulated-emission OCT signal and the traditional OCT signal obtained at the same time, molecular contrast OCT images of the samples consisting of nitride powder are reconstructed successfully.
Keywords: optical coherence tomography/
stimulated emission/
pump-probe detection/
molecular specificity
