关键词: 驱动马达/
单分子技术/
力学化学耦合
English Abstract
Advances in the mechanism of mechanochemical coupling of kinesin
Li Ming1,Ouyang Zhong-Can2,
Shu Yao-Gen1,2
1.School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;
2.Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China
Fund Project:Project supported by the National Basic Research Program of China (Grant No. 2013CB932804), the National Natural Science Foundation of China (Grant Nos. 11574329, 11322543, 11105218), and the Joint NSFC-ISF Research Program (Grant No. 51561145002).Received Date:14 July 2016
Accepted Date:02 August 2016
Published Online:05 September 2016
Abstract:Kinesin is one of the most important linear motors for intracellular transport. It has two main features. One is its persistence: at least one head is attached to the microtubule during stepping, so that it can move a long distance before detaching. Another feature is the tight mechanochemical coupling: it consumes one adenosine-triphosphate for each step. Therefore, there should be a mechanism responsible for the coordination of the two heads to achieve the high persistence and tight coupling. The underlying mechanism is the mechanochemical coupling, which is the basic issue for all chemical-driven molecular motors. Owing to the developments of single-molecule experiments and molecular dynamics simulations, a breakthrough in the coupling mechanism has been made in recent decades. In this article, we review the progress of the relevant researches from the perspective of kinematics, energetics, coordination of two heads and force generating mechanism. We also present a personal perspective on the future studies of kinesin.
Keywords: kinesin/
single molecule technology/
mechanochemical coupling
