姓　　名：周　琪
学　　科：发育生物学
电话/传真：+86-/+86-
电子邮件：zhouqi@ioz.ac.cn
通讯地址：北京市朝阳区大屯路甲3号院 中国科学院干细胞与再生医学创新研究院大楼
中国科学院动物研究所 干细胞与生殖生物学国家重点实验室 100101
更多信息：生殖工程研究组

简历介绍：
　　周琪，博士，研究员，中国科学院院士，发展中国家科学院院士。现任中国科学院党组成员、副秘书长、科技创新发展中心主任、北京分院院长。主要从事生殖、发育、干细胞等研究与转化工作。长期担任国家973计划、863计划、国家重大科学研究计划项目首席科学家，中国科学院干细胞领域战略性科技先导专项首席科学家。在体细胞重编程、干细胞多能性和细胞命运决定等基础研究，和细胞分化与转分化、基因编辑、动物克隆与遗传修饰等生物技术研究方面均取得多项原创性成果，在 Cell, Nature, Science等刊物发表SCI论文200余篇。研究成果多次入选“中国科学十大进展”等国内、国际年度科技进展。领导组建了国家干细胞资源库，致力于干细胞的临床转化，通过临床级干细胞的建立和分化、细胞治疗的安全性和有效性研究等系列工作，推动了多项国际首批胚胎干细胞来源的功能细胞的临床治疗（帕金森氏病等）研究，领导制订和发布了我国多个干细胞临床应用的标准和规范。获得国家自然科学二等奖、发展中国家科学院生物学奖、中科院杰出科技成就奖、周光召基金会****基础科学奖等奖励。
研究领域：
　　生殖、发育、干细胞等研究与转化。
社会任职：
获奖及荣誉：
承担科研项目情况：
代表论著：
(#为共同第一作者，*为通讯作者) Fu R^#, Yu D^#, Ren J^#, Li C^#, Wang J, Feng G, Wang X, Wan H, Li T, Wang L, Zhang Y, Hai T^*, Li W^*, Zhou Q^*. (2020) Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs. Protein Cell. 2020 Feb;11(2):97-107. doi: 10.1007/s13238-019-00676-8. Epub 2019 Nov 28
Cui T^#, Jiang L^#, Li T^#, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W^*, Zhou Q^*. (2019) Derivation of Mouse Haploid Trophoblast Stem Cells. Cell Rep. 26(2):407-414.e5. doi: 10.1016/j.celrep.2018.12.067.
Li Y^#, Wang L^#, Zhang L^#, He Z^#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y^*, Zhou Q^*, Li W^*. (2019) Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. J Cell Biol. 2019 May 6;218(5):1553-1563. doi: 10.1083/jcb.. Epub 2019 Feb 15.
Wang L^#, Wu W^#, Gu Q^#, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q^*, Yin Z^*, Hao J^*. (2019) The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell. 2019 Jun;10(6):455-460. doi: 10.1007/s13238-018-0606-8. Epub 2019 Jan 23.
Wang J^#, Wang L^#, Feng G^#, Wang Y^#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W^*, Zhou Q^*. (2018) Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell 2018 Dec 13;175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.
Li ZK^#, Wang LY^#, Wang LB^#, Feng GH^#, Yuan XW^#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W^*, Zhou Q^*, Hu BY^*. (2018) Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell 23(5):665-676.
Li TD^#, Feng GH^#, Li YF^#, Wang M^#, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q^*. (2017) Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A. 2017 Oct 23. pii: . doi: 10.1073/pnas.. [Epub ahead of print]
He ZQ^#, Xia BL^#, Wang YK^#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q^*. (2017) Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening. Cell Rep. 20(9):2227-2237.
Gu Q^#, Wang J^#, Wang L^#, Liu ZX, Zhu WW, Tan YQ, Han WF, Wu J, Feng CJ, Fang JH, Liu L, Wang L, Li W, Zhao XY, Hu BY, Hao J^*, Zhou Q^*. (2017) Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem Cell Reports 9(1):366-380.
Li X^#, Cui XL^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W^*, Zhou Q^*. (2016) Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 164(1-2):279–292.
Li Z^#, Wan H^#, Feng G^#, Wang L^#, He Z, Wang Y, Wang XJ, Li W^*, Zhou Q^*, Hu B^*. (2016) Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res. 26(1):135-138.
Zhou Q^#, Wang M^#, Yuan Y^#, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY^*, Sha J^*, Zhou Q^* (2016) Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. Cell Stem Cell 18(3):330-340.
Chen Q^#*, Yan M^#, Cao Z^#, Li X^#, Zhang Y^#, Shi J^#, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E^*, Zhai Q^*, Zhou Q^*. (2016) Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351(6271):397-400.
Wan H^#, Feng C^#, Teng F^#, Yang S^#, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W^*, Zhao X^*, Zhou Q^*. (2015) One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res. 25(2):258-261.
Chen Y^#, Niu Y^#, Li Y^#, Ai Z, Kang Y, Shi H, Xiang Z, Yang Z, Tan T, Si W, Li W, Xia X, Zhou Q^*, Ji W^*, Li T^*. (2015) Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell Stem Cell 17(1):116-124.
Chen T^#, Hao YJ^#, Zhang Y^#, Li MM^#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ^*, Yang YG^*, Zhou Q^*. (2015) m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 16(3):289-301.
Li X^#, Wang JQ^#, Wang LY^#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q^*. (2015) Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. J Mol Cell Biol. 7(5):486-488.
Shuai L^#, Wang Y^#, Dong M^#, Wang X^#, Sang L, Wang M, Wan H, Luo G, Gu T, Yuan Y, Feng C, Teng F, Li W, Liu X, Li T, Wang L, Wang XJ, Zhao XY, Zhou Q^*. (2015) Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro. J Mol Cell Biol. 7(4):326-337.
Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W,Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q. (2015) CRISPR germline engineering—the community speaks. Nat. Biotechnol. 33(5):478-486.
Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi Y-M, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha H-Y, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang S-M, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo S-K, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh S-K, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN^*, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan B-Z, Zeng F, Zhou Q. (2015) Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI). Regen. Med. 10(2s):1-44.
.Wang J^#, Hao J^#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z^*, Zhou Q^*. (2015) Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. Stem Cell Res Ther. 2015 Nov 12;6(1):223. doi: 10.1186/s13287-015-0206-y.
Li W^#, Li X^#, Li T^#, Jiang MG^#, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q^*. (2014) Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 14(3):404-414.
Hai T^#, Teng F^#, Guo R, Li W, Zhou Q^*. (2014) One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res. 24(3):372-375.
Zhou Q^*. (2014) Balancing the welfare: the use of non-human primates in research. Trends Genet. 30(11):476-478.
Gu Q^#, Hao J^#, Hai T^#, Wang J^#, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z^*, Zhou Q^*. (2014) Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein Cell. 5(5):338-342.
Li W^#, Teng F^#, Li T, Zhou Q^*. (2013) Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat. Biotechnol. 31(8):684–686.
Wan H^#, He Z^#, Dong M, Gu T, Luo GZ, Teng F, Xia B, Li W, Feng C, Li X, Li T, Shuai L, Fu R, Wang L, Wang XJ, Zhao XY^*, Zhou Q^*. (2013) Parthenogenetic haploid embryonic stem cells produce fertile mice. Cell Res. 23(11):1330-1333.
Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ^*, Zhou Q^*. (2013) MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. J Biol. Chem. 288(33):23659–23665.
Li W^#, Shuai L^#, Wan H^#, Dong M^#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY^*, Zhou Q^*. (2012) Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490(7420):407-411.
Sheng C^#, Zheng Q^#, Wu J^#, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z^*, Zhou Q^*. (2012) Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res. 22(1):208-218.
Sheng C^#, Zheng Q^#, Wu J^#, Xu Z, Sang L, Wang L, Guo C, Zhu W, Tong M, Liu L, Li W, Liu ZH, Zhao XY, Wang L, Chen Z^*, Zhou Q^*. (2012) Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors. Cell Res. 22(4):769-772.
Gu Q^#, Hao J^#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q^*. (2012) Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein Cell. 3(1):71-79.
Tong M^#, Lv Z^#, Liu L^#, Zhu H^#, Zheng QY^#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng F, Wang L, Wang XJ, Sha JH^*, Zhou Q^*. (2011) Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. Cell Res. 21(11):1634-1637.
Li W^#, Zhao XY^#, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L^*, Zhou Q^*. (2011) iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Res. 21(3):550-553.
Riaz A^#, Zhao X^#, Dai X^#, Li W, Liu L, Wan H, Yu Y, Wang L, Zhou Q^*. (2011) Mouse cloning and somatic cell reprogramming using electrofused blastomeres. Cell Res. 21(5):770-778.
Niu Y^#, Yu Y^#, Bernat A^#, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P^*, Zhang K^*, Zhou Q^*, Ji W^*. (2010) Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. Proc. Natl. Acad. Sci. U. S. A. 107(41):17663-17667.
Zhao XY, Lv Z, Li W, Zeng F^*, Zhou Q^*. (2010) Production of mice using iPS cells and tetraploid complementation. Nat. Protoc. 5(5):963-971.
Liu L^#, Luo GZ^#, Yang W^#, Zhao X^#, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ^*, Zhou Q^*. (2010) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J. Biol. Chem. 285(25):19483-19490.
Dai X^#, Hao J^#, Hou XJ^#, Hai T, Fan Y, Yu Y, Jouneau A, Wang L, Zhou Q^*. (2010) Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. J. Biol. Chem. 285(40):31002-31010.
Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F^*, Zhou Q^*. (2009) iPS cells produce viable mice through tetraploid complementation. Nature 461(7260):86-90.
Dai XP, Hao J, Zhou Q^*. (2009) A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos. Reproduction 138(2):301-308.
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.Ma M^#, Guo X^#, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R^*, Sha J, Zhou Q^*. (2008) Protein expression profile of the mouse metaphase-II oocyte. J. Proteome Res. 7(11):4821-4830.
.Mai Q^#, Yu Y^#, Li T, Wang L, Chen MJ, Huang SZ^*, Zhou C^*, Zhou Q^*. (2007) Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Res. 17(12):1008-1019.
Yang J, Yang S, Beaujean N, Niu Y, He X, Xie Y, Tang X, Wang L, Zhou Q^*, Ji W^*. (2007) Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro. Biol. Reproduc. 76(1):36-42.
Yang S^*, He X, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Zhou Q^*, Ji W^*. (2007) Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys. Theriogenology 67(6):1194-1201.
Zhou Q^#*, Yang SH^#, Ding CH^#, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP^*, Ji WZ^*. (2006) A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Hum. Reproduc. 21(10):2564-2571.
Li T, Zheng J, Xie Y, Wang S, Zhang X, Li J, Jin L, Ma Y, Wolf DP, Zhou Q^*, Ji W^*. (2005) Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. Stem Cells 23(9):1295-1303.
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写给考生的话：
　　学而不思则罔，思而不学则殆。—《论语》