姓　　名：王琛柱
学　　科：生物化学及分子生物学
电话/传真：+86-/+86-
电子邮件：czwang@ioz.ac.cn
通讯地址：北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 100101
更多信息：昆虫行为生理和生物化学研究组

简历介绍：
　　王琛柱，男，博士，中国科学院动物研究所研究员，博士生导师。2009年国家****科学基金获得者。中国科学院研究生院教授，农业虫害鼠害综合治理研究国家重点实验室学术委员会学术带头人，昆虫行为生理学和生物化学研究组组长。
　　1985年获山西农业大学学士学位，1988年和1991年分别获北京农业大学（现中国农业大学）硕士、博士学位。1991－1993年中国科学院动物研究所博士后。1993年任中国科学院动物研究所副研究员，1997年任研究员至今。曾赴美国University of Arizona、荷兰Wageningen University、英国University of Cambridge等机构进行访问和合作研究。
研究领域：
　　嗅觉和味觉对于动物的生存和繁衍至关重要，在昆虫的觅食、择偶、识别亲属过程中起关键作用。王琛柱实验室的研究主要揭示昆虫选择寄主植物和寻找配偶的神经生物学机制。蛾类昆虫具有发达的化学感觉系统，因而作为我们研究的主要模型。在国家****科学基金项目、国家自然科学基金重点项目、国家重点基础研究发展规划项目的支持下，我们长期以我国重要农业害虫----广食性的棉铃虫和专食性的烟青虫为主要研究对象，揭示了两个近缘种寄主选择和信息素通信的生理、生化和分子机理。首次在室内建立种间杂交体系，系统研究了植物--害虫--寄生蜂间的防御与反防御、适应与反适应的关系，阐明了棉铃虫与烟青虫识别各自性信息素、保持种间生殖隔离的神经生物学机制。近年来，我们综合利用基因组编辑、分子生物学、神经生物学、行为学的方法和技术，研究（1）昆虫的嗅觉和味觉感受神经元及其受体的结构与功能，（2）昆虫的外周和中枢神经系统对化学信号的编码机制，从而阐释生物互作和化学通信系统的协同演化，为合理治理重要农业害虫提供新思路、新方法和新途径。
社会任职：
　　现兼任SCI期刊Arthropod-Plant Interactions副主编，Entomologia Experimentalis et Applicata、Insect Science和Archives of Insect Biochemistry and Physiology编委，Journal of Comparative Physiology A顾问委员；中文核心期刊《应用昆虫学报》副主编，《昆虫学报》和《植物保护学报》编委；亚太地区化学生态学家协会理事，中国昆虫学会常务理事。
获奖及荣誉：
承担科研项目情况：
　　目前主持科技部国家重点研发计划项目课题、国家自然科学基金重点项目和面上项目，参加中国科学院战略性先导科技专项。
代表论著：
Tang R, Jiang NJ, Ning C, Li GC, Huang LQ, Wang CZ. 2020. The olfactory reception of acetic acid and ionotropic receptors in the Oriental armyworm, Mythimna separata Walker. Insect Biochemistry and Molecular Biology 118: 103312.
Sun YL, Dong JF, Huang LQ, Wang CZ. 2020. The cotton bollworm endoparasitoid Campoletis chlorideae is attracted by cis-jasmone or cis-3-hexenyl acetate but not by their mixtures. Arthropod-Plant Interactions 14: 169-179.
Chen CY, Liu YQ, Song WM, Chen DY, Chen FY, Chen XY, Chen ZW, Ge SX, Wang CZ, Zhan S, Chen XY, Mao YB. 2019. An effector from cotton bollworm oral secretion impairs host plant defense signaling. Proceedings of the National Academy of Sciences: .
Jiang NJ, Tang R, Wu H, Xu M, Ning C, Huang LQ, Wang CZ. 2019. Dissecting sex pheromone communication of Mythimna separata (Walker) in North China from receptor molecules and antennal lobes to behavior. Insect Biochemistry and Molecular Biology 111: 103176.
Wu H, Li RT, Dong JF, Jiang NJ, Huang LQ, Wang CZ. 2019. An odorant receptor and glomerulus responding to farnesene in Helicoverpa assulta (Lepidoptera: Noctuidae). Insect Biochemistry and Molecular Biology 115: 103106.
Zhang ZJ, Zhang SS, Niu BL, Ji DF, Liu XJ, Li MW, Bai H, Palli SR, Wang CZ, Tan AJ. 2019. A determining factor for insect feeding preference in the silkworm, Bombyx mori. PLoS Biology 17: e**.
Sun YL, Dong JF, Ning C, Ding PP, Huang LQ, Sun JG, Wang CZ. 2019. An odorant receptor mediates the attractiveness of cis-jasmone to Campoletis chlorideae, the endoparasitoid of Helicoverpa armigera. Insect Molecular Biology 28: 23-34.
Guo H, Kunwar K, Smith D. 2020. Multiple channels of DEET repellency in Drosophila. Pest Management Science 76: 880-887.
Keesey IW, Jiang N, Weissflog J, Winz R, Svatos A, Wang CZ, Hansson BS, Knaden M. 2019. Plant-based natural product chemistry for integrated pest management of Drosophila suzukii. Journal of Chemical Ecology 45: 626-637.
Guo H, Wang CZ. 2019. The ethological significance and olfactory detection of herbivore-induced plant volatiles in interactions of plants, herbivorous insects, and parasitoids. Arthropod-Plant Interactions 13: 161-179.
Yang K, Huang LQ, Ning C, Wang CZ. 2017. Two single-point mutations shift the ligand selectivity of a pheromone receptor between two closely related moth species. eLife 6: e29100.
Li RT, Ning C, Huang LQ, Dong JF, Li X, Wang, CZ. 2017. Expressional divergences of two desaturase genes determine the opposite ratios of two sex pheromone components in Helicoverpa armigera and Helicoverpa assulta. Insect Biochemistry and Molecular Biology 90: 90-100.
Di C, Ning C, Huang LQ, Wang CZ. 2017. Design of larval chemical attractants based on odorant response spectra of odorant receptors in the cotton bollworm. Insect Biochemistry and Molecular Biology 84: 48-62.
Yang, L., Wang, X., Bai, S., Li, X., Gu, S., Wang, C.-Z., Li, X., 2017. Expressional divergence of insect GOX genes: From specialist to generalist glucose oxidase. Journal of Insect Physiology 100: 21-27.
Cheng Q, Gu S, Liu Z, Wang CZ, Li X. 2017. Expressional divergence of the fatty acid-amino acid conjugate-hydrolyzing aminoacylase 1 (L-ACY-1) in Helicoverpa armigera and Helicoverpa assulta. Scientific Reports 7: 8721.
Xu M., Dong JF., Wu H, Zhao XC, Huang LQ, Wang CZ. 2017. The inheritance of the pheromone sensory system in two Helicoverpa species: dominance of H. armigera and possible introgression from H. assulta. Frontiers in Cellular Neuroscience 10: 302.
Zhu J, Iovinella I, Dani FR, Liu YL, Huang, LQ, Liu Y, Wang CZ, Pelosi P, Wang G. 2016. Conserved chemosensory proteins in the proboscis and eyes of Lepidoptera. International Journal of Biological Sciences 12: 1394-1404.
Xu M, Guo H, Hou C, Wu H, Huang LQ, Wang CZ. 2016. Olfactory perception and behavioral effects of sex pheromone gland components in Helicoverpa armigera and Helicoverpa assulta. Scientific Reports 6: 22998.
Tang R, Zhang F, Kone N, Chen JH, Zhu F, Han RC, Lei CL, Kenis M, Huang LQ, Wang CZ. 2016. Identification and testing of oviposition attractant chemical compounds for Musca domestica. Scientific Reports 6: 33017.
Ning C, Yang K, Xu M, Huang LQ, Wang CZ. 2016. Functional validation of the carbon dioxide receptor in labial palps of Helicoverpa armigera moths. Insect Biochemistry and Molecular Biology 73: 12-19.
Wu H, Xu M, Hou C, Huang LQ, Dong JF, Wang CZ. 2015. Specific olfactory neurons and glomeruli are associated to differences in behavioral responses to pheromone components between two Helicoverpa species. Frontiers in Behavioral Neuroscience 9.
Lu PF, Wang R, Wang CZ, Luo YQ, Qiao HL. 2015. Sexual differences in electrophysiological and behavioral responses of Cydia molesta to peach and pear volatiles. Entomologia Experimentalis et Applicata 157: 279-290
Jiang XJ, Chao N, Guo H, Jia YY, Huang LQ, Qu MJ, Wang CZ. 2015. A gustatory receptor tuned to D-fructose in antennal sensilla chaetica of Helicovera armigera. Insect Biochemistry and Molecular Biology 60:39-46
写给考生的话：
　　“对于一名生物****来说，令自己感到羞辱但极为高兴的体验，莫过于其自以为是的想法被大自然简单的事实所修正。对生命系统如何运作的好奇诱使他追踪细微的线索，而当踪迹好像消失的时候他提出假说，通常是一个接着一个。假说实际上是一种痴心妄想；当事实真相被面对面揭露的时候，假说将不复存在。然而，如果没有了假说和痴心妄想，生活将枯燥得无法忍受。” ――神经行为学家Ken Roeder