姓　　名：何宏轩
学　　科：生物化学及分子生物学
电话/传真：+86-/
电子邮件：hehx@ioz.ac.cn
通讯地址：北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 中国科学院动物生态与保护生物学重点实验室 100101
更多信息：野生动物疫病研究组

简历介绍：
　　何宏轩，博士，男，汉族，现为中国科学院动物研究所研究员，博士生导师，动物疫病研究组组长。《Molecular and Biochemistry》，《生物物理和生物化学》，《微生物学报》等杂志审稿人。中国动物学会和中国畜牧兽医学会会员。
　　1993年7月毕业于河南职业技术师范学院，获学士学位，1998年6月毕业于解放军农牧大学，获硕士学位，2002年6月毕业于解放军军需大学，获博士学位，2003年在清华大学生物科学与技术系作博士后研究，2004年在美国康乃尔大学作博士后研究。曾经获得河南省优秀中青年骨干教师，河南省教育系统学术技术带头人，河南省****等荣誉。曾在河南科技学院工作，自1996年起先后担任教研室主任、系副主任、系主任、副院长等职务。1999年7月任讲师，2002年6月任副教授，2005年8月任教授。2004年被河北师范大学和河南农业大学聘为硕士生导师，2006年被中国科学院动物研究所聘为博士生导师。
　　曾主持或参加 “十一五” 国家科技支撑重点项目、国家重点基础研究发展计划（973计划）、国家高技术研究发展计划（863）、国家自然科学基金、中国博士后基金以及河南省****基金等20余项。获得省部级科研奖7项。在《Emerging infectious diseases》、 《Journal of infectious diseases》、《Reviews in medical virology》 、《Vaccine》、《DNA and Cell Biology》、《Journal of Nanoscience and Nanotechnology》、《生物化学和生物物理进展》等国内外期刊发表学术论文120余篇。编写著作9部。。
工作经历
　　2006年1月－至今 中国科学院动物研究所，研究员，博士生导师
　　2005年8月－2005年12月 河南科技学院动物科学学院，教授
　　2004年10月－2005年11月 美国康乃尔大学兽医学院，博士后
　　2003年1月－2004年10月 清华大学生物科学与技术系，博士后
　　2002年6月－2005年8月 河南科技学院动物科学系，副教授
　　1999年7月－2002年6月 河南科技学院动物科学系，讲师
　　1993年7月－1999年7月 河南职业技术师范学院畜牧兽医系，助教
学历
　　1999年9月－2002年6月 中国人民解放军军需大学畜牧兽医学院，获农学博士学位
　　1996年9月－1998年6月 中国人民解放军农牧大学畜牧兽医学院，获农学硕士学位
　　1989年9月－1993年6月 河南科技学院畜牧兽医系，获农学学士学 研究领域：
　　研究兴趣主要集中在了解主要疾病疫源地生态和主要宿主迁徙动态、生境利用及其与家畜和人类活动关系的基础上，开展病原的检测和溯源研究，以及病原与宿主的协同进化关系；从人兽共患病病原体和宿主的关系入手，根据生物信息学原理和协同进化理论，运用病原学和分子生物学方法，调查野生动物病原多样性，揭示自然条件下野生动物源性疫病发生发展规律以及未知病原体/重大疫病对野生动物/家养动物/人类的内在影响机制。
社会任职：
国家林业局中国科学院野生动物疫病研究中心常务副主任
国家林业局野生动物疫病预警与防控专家组成员
亚太野生动物疫病合作网络中方负责人
国际野生动物疫病协会理事
亚洲生物技术协会联合会委员
国际动物学会会员
《中国媒介生物学及控制杂志》编委
《Integrative Zoology（整合动物学）》编委
《Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases》特约审稿人
《American Journal of Tropical Medicine & Hygiene》特约审稿人
《Journal of Helminthology》特约审稿人
《PloS one》特约审稿人
获奖及荣誉：
承担科研项目情况：
国家科技支撑计划课题，2009BAI83B00，项目名称：人兽共患病感染动物模型技术研究及我国特有野生动物实验动物化，2009BAI83B01，课题名称：重要人兽共患病野生动物野生和室内种群实验室感染模型的建立及差异性研究，2010-2012.
国家高技术研究发展计划（863）（2007AA100606）：重大动物疫病快速检测试剂的研发2007-2010。
国家重点基础研究发展计划（973计划）：农业鼠害暴发成灾规律、预测及可持续控制的基础研究（**BC109103），2007-2012。
科技部十二五支撑, 野生动物跨境传播重要疫病监测与防控技术研究（“十二五”国家科技支撑计划2013BAD12B04），2013-2017。
国家自然科学基金，TRX-2抗氧化系统在缺硒状态宿主中抗微小隐孢子虫感染的作用机制研究（**），2011-2013。
国家自然科学基金，MicroRNA参与调控微小隐孢子虫感染缺硒宿主的分子机制研究（**），2012-2014.
国家林业局野生动物疫源疫病监测项目，候鸟禽霍乱疫源地追溯及其预警体系的建立，2014-2015。
现代农业产业技术体系北京市家禽创新团队，疫病控制岗位专家，2010-2015。
代表论著：
Shelan Liu, Chengliang Chai, Chengmin Wang, Said Amer,Huakun Lv, Hongxuan He, Jimin Sun and Junfen Lin. Systematic review of severe fever with thrombocytopenia syndrome:virology, epidemiology, and clinical characteristics. Reviews In Medical Virology 2014, 24: 90-102.

Guo Yunhai, Hongxuan He. Identification and characterization of a goose-type lysozyme from sewage snail Physa acuta.Fish & Shellfish Immunology,2014, 39 (2 ): 321-325.

Liu Huimin, YanJing, WangYutian, YanQi, ZhaoLinping, YanRuoqian, Hongxuan He. Isolation of Moraxella bovoculi from racehorses with keratoconjunctivitis. Journal Of Veterinary Diagnostic Investigation, 2014, 26 (4 ): 585-587.

Liu Huimin, YanJing, Luo Jing, Yan Ruoqian, ChenHao , ChengHai, LiuDawei, Hongxuan He.Mycobacteriosis Associated with Mycobacterium peregrinum Infection in Red-Crowned Cranes (Grus japonensis) in China. journal of wildlife diseases, 2014, 50(3 ): 703-706.

GaoShanshan, ZhangMin, AmerSaid, LuoJing, WangChengmin, WuShaoqiang, ZhaoBaohua, Hongxuan He.Development of an immunomagnetic bead separation-coupled quantitative PCR method for rapid and sensitive detection of Cryptosporidium parvum oocysts in calf feces. Parasitology Research,2014, 13 ( 6 ): 2069-2077.

Liu Huimin, WangYutian, YanJing, WangChengmin, Hongxuan He.Appearance of Multidrug-Resistant Virulent Rhodococcus equi Clinical Isolates Obtained in China. Journal Of Clinical Microbiology, 2014,52(2 ): 703-703

Tao Zhang and Hongxuan He. Test of immunocompetence handicap hypothesis in mice (Mus musculus) infected with Trichinella spiralis. Canadian Journal of Zoology, 2014,92: 817–821

Joy Scaria , Jenn-Wei Chen, Nicodemus Useh, Hongxuan He , Sean P. McDonough , Chunhong Mao , Bruno Sobral , Yung-Fu Chang.Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays . International Journal of Infectious Diseases ,27 (2014) e20–e25

Guoying Dong,Jing Luo, Kai Zhou ,Bin Wu,Chao Peng,Guangju Ji,Hongxuan He. Characterization of the amantadine-resistant H5N1 highly pathogenic avian influenza variants isolated from quails in Southern China. Virus Genes, 2014. 49(2) 223-232.

Chengmin Wang, Jing Luo,Jing Wang,Wen Su, Shanshan Gao, Min Zhang, Li Xie,Hua Ding, Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hongxuan He. Novel human H7N9 Influenza Virus in China. Integrative Zoology, 2014,9: 356–361.

Chengmin Wang, Jing Wang, Wen Su, Shanshan Gao, Jing Luo, Min Zhang, Li Xie, Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hong Zhang, Hua Ding, Hongxuan He. Relationship between domestic and wild birds in live poultry market and a novel human H7N9 virus in China. The Journal of Infectious diseases, 2014,209(1):34-37.

Yingchun Du, Jing Luo, Chengmin Wang, Qingna Wen, Mingxing Duan, Hong Zhang, and Hongxuan He.Detection of Drug-Resistant Klebsiella pneumoniae in Chinese hares (Lepus sinensis). Journal of Wildlife Disease,2014,50(1):109-12

Jing Luo, Guoying Dong, Kai Li, Zongji Lv, Xiaowei Huo, and Hongxuan He. Exposure to swine H1 and H3 and avian H5 and H9 influenza A viruses among feral swine in southern China, 2009. Journal of Wildlife Diseases, 2013,49(2):375-380.

Jun-Song Wu, Na Zhao, Hao Pan, Cheng-Min Wang, Bin Wu, Hong-Mei Zhang,Hongxuan He, Dan Liu, Said Amer, She-Lan Liu.Patterns of polymorphism and divergence in the VP1 gene of enterovirus 71 circulating in the Asia-Pacific region between 1994 and 2013.Journal of Virological Methods, 2013,193:713–728.

She-Lan Liu, Jing Wang, Xu-Hui Yang, Jin Chen, Ren-Jie Huang,Bing Ruan, Hongxuan He, Chengmin Wang, Hong-Mei Zhang,Zhou Sun, Li Xie and Hui Zhuang. Pandemic influenza A(H1N1) 2009 virus in pregnancy. Reviews in Medical Virology, 2013,23: 3–14.

Chengmin Wang，Hongxuan He. Leptospira spp. in Commensal Rodents, Beijing, China. Journal of Wildlife Diseases,2013,49(2):461-463.

Chengmin Wang, Yanyu Zhang, Bin Wu, Shelan Liu, Ping Xu, Yanmin Lu, Jing Luo, Dale Louis Nolte, Thomas Jude Deliberto, Mingxing Duan, Hong Zhang, Hongxuan He. Evolutionary characterization of the pandemic H1N1/2009 Influenza Virus in humans based on non-structural genes. PLoS ONE,2013, 8(2): e56201.

Shanshan Gao,Na Zhaoa, Said Amer, Mingming Qian, Mengxi Lv, Yuliang Zhao, Xin Su, Jieying Cao, Hongxuan He, Baohua Zhao.Protective efficacy of PLGA microspheres loaded with divalent DNA vaccine encoding the ompA gene of Aeromonas veronii and the hly gene of Aeromonas hydrophila in mice,Vaccine,2013,48(19):5754-5759.

Liu H, Yan Q, Zhao B, Luo J, Wang C, Du Y, Yan J, Hongxuan He. Isolation, molecular characterization, and phylogenetic analysis of encephalomyocarditis virus from South China tigers in China. Infection, Genetics and Evolution,2013,19:240–243.

Liu H, Yan Q, Hongxuan He. Complete Nucleotide Sequence of Encephalomyocarditis Virus Isolated from South China Tigers in China. Genome A,1(4):e00651-13.

Zhang Min and Hongxuan He. Parasite-mediated selection of major histocompatibility complex variability in wild brandt’s voles (Lasiopodomys brandtii) from Inner Mongolia, China. BMC Evolutionary Biology, 2013, 13:149.

Hu Yi , LIU Peng-Peng, ZHANG Zhi-Ming, LU He-Zhen, LUO Jing, WANG Cheng-Min,LIU Jun-Xu, ZHAO Bao-Hua, Hongxuan He.Inhibition of Highly Pathogenic Avian Influenza A Virus H5N1 Growth and Induction of Inflammatory Mediators by Geldanamycin Progress in Biochemistry and Biophysics,2013, 40(11): 1132~1139

Chengmin Wang,Jing Wang,Jing Luo,Li Xie,Hua Ding,Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hongxuan He. Relationship between H7subtype avian influenza virus and poultry and human. Progress in Biochemistry and Biophysics,2013, 40(5): 416~424.

Wenjie Dong, Jing Luo, Hongxuan He, Long Jiang. A reinforced composite structure composed of polydiacetylene assemblies deposited on polystyrene microspheres and its application to H5N1 virus detection. International Journal of Nanomedicine,2013:8:221 - 232

Shelan Liu, Chengliang Chai, Chengmin Wang, Said Amer,Huakun Lv, Hongxuan He, Jimin Sun and Junfen Lin.Systematic review of severe fever with thrombocytopenia syndrome:virology, epidemiology, and clinical characteristics. Reviews in Medical Virology, 2013, DOI: 10.1002/rmv.1776

Shelan Liu, Jing Wang, Xului Yang, Jin Chen, Renjie Huang, Bing Ruan, Hongxuan He, Chengmin Wang, Hongmei Zhang, Zhou Sun, Li Xie, Hui Zhuang. Pandemic influenza A(H1N1) 2009 virus in pregnancy. Reviews in Medical virology, 2013,23: 3–14.

Jing Luo, Zhigao Zeng, Yanling Song, Hongxuan He. Brucellosis in Takins, China. Emerging Infectious Diseases ,2012,18(9):1527-1529.

Sarah N. Bevins, John A. Baroch, Dale L. Nolte, Min Zhang, Hongxuan He. Yersinia pestis: examining wildlife plague surveillance in China and the USA. Integrative Zoology,2012,7(1):99-109.

Didi Chen, Pei Guo, Sha Chen, Yu Cao, Wanzhen Ji, Xia Lei, Lina Liu, Peiguang zhao, Ruihong Wang, Chao qi, Yanli Liu, Hongxuan He. Properties of xyloglucan hydrogel as the biomedical sustained-release carriers. Journal of Materials Science: Materials in Medicine, 2012,23(4):955-962.

Qiumei Shi, Yanying Zhang, Qiuyue Wang, Guisheng Gao, Hai Fang, Fuchun Miao, Zengqiang Yuan and Hongxuan He. Phylogenetic analysis of virulence factor gene of Salmonella isolated from clinically symptomatic Chickens. African Journal of Microbiology Research, 2012,6(8), 1718-1722.

Hua Fu, Liguo Liu, Xiaobing Zhang, Yafang Zhu, Lina Zhao, Junping Peng, Hongxuan He, Qi Jin.Common Changes in Global Gene Expression Induced by RNA Polymerase Inhibitors in shigella flexneri. PLOS One, 2012, 7 (3): e33240

Qiumei Shi, Guisheng Gao,Yanying Zhang, Hua xiang, Zengqiang Yuan, Hongxuan He. Cloning of structural protein VP1 gene of foot and mouth Disease virus and its expression in Escherichia coli. Journal of Animal and Veterinary Advances, 2012,11(3):426-430.

Hanwei Jiao,Li Du,Yongchang Hao,Ying Cheng ,Jing Luo,wenhua Kuang,Donglin Zhang, Ming Lei ,Xiaoxiao Jia, Xiaoru Zhang , Chao Qi, Hongxuan He,Fengyang Wang. Effective inhibition of mRNA accumulation and protein expression of H5N1 avian influenza virus NS1 gene in vitro by small interfering RNAs. Folia Microbiol, 2012, DOI 10.1007/s12223-012-0212-8.

Wang BaoLin, Liu Bo, Chen Ling, Zhang JianYong, Hongxuan He,Zhang Hong. Qualitative and quantitative analyses of influenza virus receptors in trachea and lung tissues of humans, mice, chickens and ducks. Sci China Life Sci,2012, 55:612–617.

Wei Lei,Qinglong Liang,Luo Jing,Chengmin Wang, Xiaobing Wu,Hongxuan He. BoLA-DRB3 gene polymorphism and FMD resistance or susceptibility in Wanbei cattle. Mol Biol Rep,2012,39:9203–9209.

Chengmin Wang, Jing Luo, Said Amer, Yunhai Guo, Yi Hu, Yanmin Lu, Haijing Wang, Mingxing Duan, Hongxuan He. Multivalent DNA vaccine induces protective immune responses and enhanced resistance against Cryptosporidium parvum infection. Vaccine 2011,29, 323–328.

Kai Li, Jing Luo, Chengmin Wang, Hongxuan He. a-Galactosylceramide potently augments M2e-induced protective immunity against highly pathogenic H5N1 avian influenza virus infection in mice. Vaccine, 2011,29:7711–7717

Qing-long Liang, Jing Luo, Kai Zhou, Jian-xin Dong, Hongxuan He. Immune-related gene expression in response to H5N1 avian influenza virus infection in chicken and duck embryonic fibroblasts. Molecular Immunology,2011,48:924–930.

Guoying Dong, Jing Luo, Hong Zhang, Chengmin Wang, Mingxing Duan, Thomas Jude Deliberto,Dale Louis Nolte, Guangju Ji, Hongxuan He.Phylogenetic Diversity and Genotypical Complexity of H9N2 Influenza A Viruses Revealed by Genomic Sequence Analysis. PLoS ONE,2011, 6(2): e17212.

Guoying Dong, Cong Xu, Chengmin Wang, Bin Wu, Jing Luo, Hong Zhang, Dale Louis Nolte, Thomas Jude Deliberto, Mingxing Duan, Guangju Ji, Hongxuan He.Reassortant H9N2 Influenza Viruses Containing H5N1-Like PB1 Genes Isolated from Black-Billed Magpies in Southern China. PLoS ONE,2011,6(9): e25808.

Liu SL, Zhang Z, Wang C, Dong Y, Pan H, Sun Z, Yang XH, Wang J, Ruan B, Xie L, Deng J, Hongxuan He. Evolutionary Characterization of Human H1N1 Influenza Virus Hemagglutinin Genes Isolated from 1947 to 2009 in China. Intervirology,2011,DOI: 10.1159/.

Yuelan Zhao, Chengmin Wang, Yanmin Lu, Said Amer, Ping Xu,Jianyong Wang, Junxia Lu, Yongzhan Bao, Bolin Deng, Hongxuan He,Jianhua Qin. Prokaryotic Expression and Identification of 3-1E Gene of merozoite surface antigen of Eimeria acervulina. Parasitology Research, 2011,109:1361–1365.

Qiumei Shi, Guisheng Gao, Yanying Zhang,Hua Xiang,Zengqiang Yuan, Hongxuan He. Cloning of structural protein VP1 gene of foot and mouth virus and its expression in Escherichia coli. Journal of Amimal and Veterinary Advances,2011,11(3):426-430

Yu cao, didi chen, peiguang zhao, lina liu, xueying huang, chao qi, yanli liu,Hongxuan He, qian wang, yang liu, and sha chen. Intracellular Delivery of Mitomycin C with Targeted Polysaccharide Conjugates Against Multidrug Resistance. Annals of Biomedical Engineering,2011, DOI: 10.1007/s10439-011-0333-2.

Lei Wei, Xinwei Wang, Chengmin Wang and Hongxuan He. A survey of ectoparasites from wild rodents and Anourosorex squamipes in Sichuan Province, Southwest China. Journal of Ecology and the Natural Environment, 2010, 2(8), 160-166.

Said Amer, Chengmin Wang and Hongxuan He. First Detection of Cryptosporidium baileyi in Ruddy Shelduck (Tadorna ferruginea) in China. J. Vet. Med. Sci. 2010, 72(7): 935–938.

Chengmin Wang, Bin Wu, Said Amer, Jing Luo, Hongmei Zhang, Yunhai Guo, Guoying Dong, Baohua Zhao,Hongxuan He. Phylogenetic analysis and molecular characteristics of seven variant Chinese field isolates of PRRSV. BMC Microbiol,2010. doi:10.1186/1471-2180-10-146.

Bin Wu, Chengmin Wang, Guoying Dong, Yunhai Guo, Dale Louis Nolte, Thomas Jude Deliberto, Jianguo Xu,Mingxing Duan, Hongxuan He.New Evidences Reveal Southern China Is a common Source of Multiple H5N1 Clusters. The Journal of Infectious Diseases, 2010, 202(3):452–458.

Qinglong Liang, Lei Wei, Xinwei Wang, Hongxuan He.MHC Class I Loci from the Bar-Headed Goose (Anser indicus).Genetics and Molecular Biology,2010,33(3):573-577

Yuelan Zhao, Said Amer, Jianyong Wang, Chengmin Wang,Ying Gao, Guiying Kang, Yongzhan Bao, Hongxuan He,Jianhua Qin. Construction, screening and identification of a phage display antibody library against the Eimeria acervulina merozoite. Biochemical and Biophysical Research Communications,2010,393:703–707.

Yu Cao, Ying Gu, Hong Ma, Jing Bai, Lina Liu, Peiguang Zhao, Hongxuan He.Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide–doxorubicin conjugate loaded doxorubicin. International Journal of Biological Macromolecules,2010, 46,245–249.

Qinglong Liang, Kai Zhou, Hongxuan He. Retrocyclin 2: a new therapy against H5N1 virus in vivo and vitro. Biotechnology Letters, 2010,32:387–392.

Tang Yi, CHU Guang-yue, Hongxuan He, YU Cui-ping, AN Jian-xiong, GUO Xiang-yang. Screening of differentially expressed genes in the hypothalamus of a rat neuropathic pain model following sciatic nerve injury. Chinese Medical Journal,2009,122(23):2893-2897.

SheLan Liu, Zhi-Ruo Zhang, Chengmin Wang, Ying Dong, Lun-Biao Cui, Xu-Hui Yang, Zhou Sun, Jing Wang, Jin Chen, Ren-Jie Huang, Fan Miao, Bing Ruan, Li Xie, Hongxuan He, Jing Deng. 2009 pandemic characteristics and controlling experiences of influenza H1N1 virus 1 year after the inception in Hangzhou, China. Journal of medical virology, 2010，82:1985–1995.

Wu B, Wang C M, Dong G Y, Hongxuan He. Molecular characterization of H1N1 influenza A viruses from human cases in North America. Chinese Sci Bull, 2009, 54(13):2179-2192.

Chengmin WANG, Hongxuan HE, Ming LI, Fumin LEI, J. Jeffrey Root, Yanyun WU, Jianhua QIN. Parasite species associated with wild plateau pika (Ochotona curzoniae) in south-eastern Qinghai Province, China. Journal of wildlife disease, 2009,45(2):288-294.

Chengmin Wang, Yanyun Wu, Jianhua Qin, Haoxue Sun, and Hongxuan He. Induced susceptibility of host is associated with an impaired antioxidant system following infection with Cryptosporidium parvum in Se-deficient mice. PLoS ONE 4(2): e4628.

Chengmin Wang, Hongxuan He, Mingxing Duan Development and evaluation of a recombinant CP23 antigen-based ELISA for serodiagnosis of Cryptosporidium parvum. Experimental Parasitology, 2009,121(2):157-162

Zhou Kai, Hongxuan He. Avian Influenza and Swine Influenza:New Understanding of Crossing Species Barrier. Progress in Biochemistry and Biophysics, 2009, 36(5): 523~529

Wang xinwei, Hongxuan He, Zelin Wang, Yanyun Wu, Chengmin Wang. Detection on antigen of infectious bronchitis virus in chicken by silver-enhanced colloidal gold assay. Chin J Vet Sci, 2009, 29 (4):204-399

Liqiang Feng,Feng Li,Xuehua Zheng,Weiqi Pan,Kai Zhou,Yichu Liu,Hongxuan He,Ling Chen. The mouse Pol I terminator is more efficient than the hepatitis delta virus ribozyme in generating influenza virus-like RNAs with precise 3' ends in a plasmid-only-based virus rescue system. Archives of Virology,2009, DOI 10.1007/s00705-009-0422-9

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