姓　　名：王昱凯
学　　科：细胞生物学
电话/传真：+86-/
电子邮件：wangyukai@ioz.ac.cn
通讯地址：北京市海淀区北四环西路25-2，中国科学院动物研究所 国家干细胞资源库 100101
更多信息：生殖工程研究组

简历介绍：
　　王昱凯，男，博士，副研究员，干细胞与生殖生物学国家重点实验室生殖工程研究组成员。主要从事干细胞命运调控与神经再生研究，尤其关注帕金森病、脑卒中等重大神经系统疾病的神经修复，相关研究成果发表在Cell，Cell reports，Stem cell reports，Cell research等刊物，已被引用200余次。
教育及工作经历:
　　2001.9-2005.7，南京工业大学，生物学学士
　　2005.9-2008.7，山东大学，理学硕士
　　2008.9-2011.7，山东大学，理学博士
　　2011.7 -2015.6，中国科学院动物研究所，博士后
　　2015.7-2019.6，中国科学院动物研究所，助理研究员
　　2019.6-至今，中国科学院动物研究所，副研究员
研究领域：
　　多能干细胞向特定亚型神经元的定向分化；在实验室中制备人的神经细胞并将其用于发育与细胞命运调控研究、疾病建模、药物筛选和神经疾病的再生治疗；开发临床级多巴胺能神经细胞药物，用于帕金森病患者的细胞治疗–该项目目前已开展临床研究。
社会任职：
获奖及荣誉：
承担科研项目情况：
　　国家自然基金委面上基金项目，2020-2023，主持，在研
　　国家重点研发计划（973），2020-2024，参加，在研
　　国家重点研发计划（973），2019-2023，参加，在研
　　中国科学院战略性先导科技专项，2017-2022，参加，在研
　　国家自然基金委青年科学基金项目，2017-2019，主持，结题
　　中国科学院重点部署项目，2017-2018，参加，结题
　　国家自然基金委面上项目，2014-2017，参加，结题
　　国家自然基金委重点项目，2014-2016，参加，结题
　　国家重点研发计划（973），2013-2017，参加，结题
代表论著：
Wang YK^#, Zhu WW^#, Wu MH^#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports, 2018, 11(1): 171-182
Wang JQ^#, Wang LY^#, Feng GH^#, Wang YK^#, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Cell, 2018, 175(7): 1887-1901
Wang XP^#, Li TD^#, Cui TT^#, Yu DW^#, Liu C^#, Jiang LY, Feng GH, Wang L, Fu R, Zhang XX, Hao J, Wang YK, Wang L, Zhou Q, Li W, Hu BY, Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis, Cell Research, 2018, 28(1): 126-129
Li X^#, Ma RY^#, Gu Q^#, Liang LM, Wang L, Zhang Y, Wang XN, Liu X, Li ZW, Fang JH, Wu J, Wang YK, Li W, Hu BY, Wang L, Zhou Q, Hao J, A fully defined static suspension culture system for large-scale human embryonic stem cell production, Cell Death Dis. 2018, 9(9):892
He ZQ^#, Xia BL^#, Wang YK^#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening, Cell Reports, 2017, 20(9): 2227-2237
Lu XY^#, Wang YK^#, Yan L, Wang LB, Li W, Wang HM, Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs, Journal of Genetics and Genomics, 2016, 43(10): 609-612
Li X^#, Cu XLi^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells, Cell, 2016, 164(1-2): 279-292
Li ZK^#, Wan HF^#, Feng GH^#, Wang LY^#, He ZQ, Wang YK, Wang XJ, Li W^*, Zhou Q, Hu BY, Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells, Cell Research, 2016, 26(1): 135-138
Li ZK^#, Wang LB^#, Wang YK^#, Liu L, Wang L, Li W, Zhou Q, Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, Journal of Genetics and Genomics, 2015, 42(3): 125-128
Mao YH^#, Wang YK, Wang LB, Zhou Q, Induced Pluripotent Stem Cell, a Rising Star in Regenerative Medicine, Springer, 2015.5.30
Shuai L^#, Wang YK^#, Dong MZ^#, Wang XP^#, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro, J Mol Cell Biol, 2015, 7(4): 326-337
Wang LB^#, Cao JN^#, Wang YK^#, Lan TS^#, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, Immunogenicity and functional evaluation ofiPSC-derived organs for transplantation, Cell Discovery, 2015, 7;1:15015
Li X^#, Wang JQ^#, Wang LY^#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q, Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos, J Mol Cell Biol, 2015, 7(5): 486-488
Wang YK^#, Zhao GY^#, Li Y, Chen XL, Xie BB, Su HN, Lv YH, He HL, Liu H, Hu J, Zhou BC, Zhang YZ, Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep sea Pseudoalteromonas sp. SM9913: binding of the PKD domain to collagen results in collagen swelling but does not unwind the collagen triple helix, J Biol Chem, 2010, 285(19): 14285-14291
Wang YK^#, He HL, Wang GF, Wu H, Zhou BC, Chen XL, Zhang YZ, Oyster (Crassostrea gigas) hydrolysates produced on a plant scale have antitumor activity and immunostimulating effects in BALB/c mice, Marine Drugs, 2010, 8(2): 255-268
Wang YK^#, He HL, Chen XL, Sun CY, Zhang YZ, Zhou BC, Production of novel angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM 605, Appl Microbiol Biotechnol, 2008, 79(5): 785-791
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