姓 名:周 琪学 科:发育生物学
电话/传真:+86-010-64807299/+86-10-64807306
电子邮件:zhouqi@ioz.ac.cn
通讯地址:北京市朝阳区北辰西路1号院5号
中国科学院动物研究所计划生育生殖生物学国家重点实验室100101
更多信息:生殖工程研究组
简历: 周琪,研究员,中国科学院动物研究所副所长,计划生育生殖生物学国家重点实验室主任。
1996年毕业于东北农业大学,获理学博士学位;1997年进入中国科学院发育生物学研究所博士后流动站;1999年在中国科学院发育生物学研究所获副研究员任职资格;1999-2002年,法国国家农业研究中心(INRA)分子发育生物学部博士后;2001年入选中国科学院“百人计划”。2002年12月加入中国科学院动物研究所,任研究员。
周琪研究员主要从事细胞重编程机制和命运调控、干细胞多能性获得与维持等研究工作,并致力于推动再生医学和应用。周琪研究组现已建立了包括小鼠、大鼠在内的多种克隆及转基因动物模型;证明了小鼠克隆的可重复性;国际首次利用体细胞成功克隆大鼠;首次证明iPS细胞具有发育为健康小鼠的能力,与胚胎干细胞具有相似的多能性;发现并明确证实决定哺乳动物(小鼠)干细胞多能性的关键基因决定簇,并探索了其调控机制;证明iPS细胞来源的小鼠具有与胚胎干细胞来源小鼠相同的生理功能但具有致瘤倾向性;通过外源因子诱导实现了细胞跨胚层转分化,获得具有自我更新及分化为神经元能力的神经干细胞;利用基因修饰的单倍体胚胎干细胞成功获得健康成活的转基因小鼠;利用CRISPR-Cas基因修饰系统实现大鼠多基因的快速同时敲除;建立了小鼠、人等物种的胚胎干细胞系、孤雌胚胎干细胞系及iPS细胞系,依托于多能性干细胞资源建立了种子资源库,开展了细胞治疗及药物筛选等临床前基础研究及安全性评估等工作。
周琪研究员现已在
Nature,Science,NatureBiotechnology,PNAS,JBC,Stemcells,CellResearch等数家刊物发表研究论文79篇,申请、获得重编程技术发明专利6项;其研究成果多次受到国际著名科学家的高度评价与国际科技媒体的广泛报导,其中三项研究成果分别于2003年、2009年及2012年入选我国年度十大科技进展新闻、两院院士评选的十大科技进展或十大科技新闻人物,尤其是证明iPS细胞多能性的工作还入选了美国《时代周刊》评选的2009年年度十大医学突破。
周琪研究员先后获得国际转基因研究genOway奖、何梁何利基金科学与技术奖、周光召基金会“杰出青年基础科学奖”等多项奖励。
研究领域:社会任职:获奖及荣誉:- 2011年9月 周光召基金会杰出青年基础科学奖
- 2010年10月何梁何利科技与技术进步奖
- 2010年4月 第十届中国科学院杰出青年
- 2007年5月 第十一届“中国青年五四奖章”
- 2006年5月 第九届中国青年科技奖
- 2004年3月 国际转基因研究genOway奖
- 2003年5月 法中科技促进会生物技术奖
承担科研项目情况: 国家自然科学基金委员会重大研究计划重点支持项目、中国科技部国家重大科学研究计划及中国科学院战略性先导科技专项项目。
代表论著:(#为共同第一作者,*为通讯作者)
2013年度:
LiW#,LiX#,LiTD#,JiangMG#,WanHF,LuoGZ,FengCJ,CuiXL,TengF,YuanY,ZhouQ,GuQ,ShuaiL,ShaJH,XiaoYM,WangL,LiuZH,WangXJ,ZhaoXY,ZhouQ*.Geneticmodificationandscreeningintheratusinghaploidembryonicstemcells.CellStemCell.InPress.LiW,TengF,LiTD,ZhouQ*.SimultaneousgenerationandgermlinetransmissionofmultiplegenemutationsinratusingCRISPR-Cassystems.NatBiotechnol.31(2013):684–686LiW#,GuoXJ#,TengF,HouXJ,LvZ,ZhouSY,BiY,WanHF,FengCJ,YuanY,ZhaoXY,WangL,ShaJH*,ZhouQ*.Tex101isessentialformalefertilitybyaffectingspermmigrationintotheoviductinmice.JMolCellBiol.5(5)(2013):345-347ZhangXM#,MaYZ#,LiuXY,ZhouQ*,WangXJ*.EvolutionaryandFunctionalAnalysisoftheKeyPluripotencyFactorOct4andItsFamilyProteins.JournalofGeneticsandGenomics40(2013)399e412JiangMG#,LiTD#,FengCJ#,FuR,YuanY,ZhouQ,LiX,WanHF,WangL,LiW,XiaoYM,ZhaoXY*,ZhouQ*.GenerationofTransgenicRatsthroughInducedPluripotentStemCells.JBiolChem.288(2013):27150-27158.ZhangY,TengF,LuoGZ,WangM,TongM,ZhaoXY,WangL,WangXJ*,ZhouQ*.MicroRNA-323-3pRegulatestheActivityofPolycombRepressiveComplex2(PRC2)viaTargetingthemRNAofEmbryonicEctodermDevelopment(Eed)GeneinMouseEmbryonicStemCells.JBiolChem.288(33)(2013):23659–23665.LiuX,ZhangY,TongM,LiuXY,LuoGZ,XieDF,RenSF,BaiDH,WangL,ZhouQ,WangXJ*.Identificationofasmallmolecule1,4-bis-[4-(3-phenoxy-propoxy)-but-2-ynyl]-piperazineasanovelinhibitorofthetranscriptionfactorp53.ActaPharmacologicaSinica34(2013):805–810ZhouQ.Progressandprospectsinstemcelltherapyanddrugdiscovery.ActaPharmacolSin.34(2013):717–718WangJY#,GuQ#,HaoJ#,JiaYD,XueBH,JinHH,MaJ,WeiRY,HaiT,KongQR,BouG,XiaP,ZhouQ,WangL*,LiuZH*.Tbx3andNr5α2PlayImportantRolesinPigPluripotentStemCells.StemCellRevandRep.9(2013):700-708FanNN,ChenJJ,ShangZC,DouHW,JiGZ,ZhouQJ,WuL,HeLXZ,WangF,LiuK,LiuN,HanJY,ZhouQ,PanDK,YangDS,ZhaoBT,OuyangZ,LiuZM,ZhaoY,LinL,ZhongCM,WangQL,WangSQ,XuY,LuanJ,LuCX,VijtaG,LiZY,OuyangHS,WangHY,WangY,YangY,LiuZH,WeiH,LuanZD,YangHM,PeiDQ,LiN,PeiG,LiuL,DuYT,XiaoL,LaiLX.Pigletsclonedfrominducedpluripotentstemcells.CellResearch.23(2013):162-166YangCX,LiuZC,FleurotR,AdenotP,DuranthonV,VignonX,ZhouQ,RenardJP,BeaujeanN*.Heterochromatinreprogramminginrabbitembryosafterfertilization,intra-,andinter-speciesSCNTcorrelateswithpreimplantationdevelopment.Reproduction.145(2)(2013):149-1592012年度:
LiW#,ShuaiL#,WanHF#,DongMZ#,WangM,SangLS,FengCJ,LuoGZ,LiTD,LiX,WangLB,ZhengQY,ShengC,WuHJ,LiuZH,LiuL,WangL,WangXJ,ZhaoXY*,ZhouQ*.Androgenetichaploidembryonicstemcellsproducelivetransgenicmice.Nature490(7420)(2012):407-411.
?受到NatureChina等媒体的报道,并入选2012年度中国科学十大进展
http://www.nature.com/nchina/2012/121107/full/nchina.2012.72.htmlLiuZC,HaiT,DaiXP,ZhaoXY,WangYY,BrochardV,ZhouSY,WanHF,ZhangHJ,WangL,ZhouQ*,BeaujeanN*.Earlypatterningofclonedmouseembryoscontributestopost-implantationdevelopment.DevelopmentalBiology368(2)(2012):304-311.ShengC#,ZhengQY#,WuJY#,XuZ,WangLB,LiW,ZhangHJ,ZhaoXY,LiuL,WangZW,GuoCL,WuHJ,LiuZH,WangL,HeSG,WangXJ,ChenZG*,ZhouQ*.Directreprogrammingofsetolicellsintomultipotentneuralstemcellsbydefinedfactors.CellResearch22(1)(2012):208-218.ShengC#,ZhengQY#,WuJY#,XuZ,SangLS,WangLB,GuoCL,ZhuWW,TongM,LiuL,LiW,LiuZH,ZhaoXY,WangL,ChenZG*,ZhouQ*.Generationofdopaminergicneuronsdirectlyfrommousefibroblastsandfibroblast-derivedneuralprogenitors.CellResearch22(4)(2012):769-772.LiuZC#,WanHF#,WangEY#,ZhaoXY,DingCH,ZhouSY,LiTQ,ShuaiL,FengCJ,YuY,ZhouQ*,BeaujeanN*.Inducedpluripotentsteminducedcellsshowbetterconstitutiveheterochromatinremodelinganddevelopmentalpotentialafternucleartransferthantheirparentalcells.StemCellDevelopment21(16)(2012):3001-3009.WangZK#,ShengC#,LiTD#,TengF#,SangLS,CaoFL,WangZW,ZhuWW,LiW,ZhaoXY,LiuZH,WangL*,ZhouQ*.Generationoftripotentneuralprogenitorcellsfromratembryonicstemcells.JournalofGeneticsandGenomics39(12)(2012):643–651.LiTD#,ZhaoXY#,TengF,LiX,JiangMG,LiW,WangXP,WangJL,LiuL,LiuZH,WangL,ZhouQ*.DerivationofGermlineCompetentRatEmbryonicStemCellsfromDARats.JournalofGeneticsandGenomics39(11)(2012):603-606.GuQ#,HaoJ#,ZhaoXY,LiW,LiuL,WangL,LiuZH,ZhouQ*.RapidconversionofhumanESCsintomouseESC-likepluripotentstatebyoptimizingcultureconditions.Protein&Cell3(1)(2012):71-79PengHY#,ShiJC#,ZhangY,ZhangH,LiaoSY,LiW,LeiL,HanCS,NingLN,CaoYJ,ZhouQ,ChenQ*,DuanEK*.AnovelclassoftRNA-derivedsmallRNAsextremelyenrichedinmaturemousesperm.CellResearch22(11)(2012):1609-1612.WangLL#,XueY#,ShenYH#,LiW#,ChengY,YanXS,ShiWS,WangJ,GongZJ,YangGH,GuoCL,ZhouYY,WangX,ZhouQ,ZengFY*.Claudin6:anovelsurfacemarkerforcharacterizingmousepluripotentstemcells.CellResearch22(6)(2012):1082-1085.GuoCL#,LiuL#,JiaYD,ZhaoXY,ZhouQ,WangL*.AnovelvariantofOct3/4geneinmouseembryonicstemcells.StemCellResearch9(2)(2012):69-76.ChenYC#,NiuYY#,YangSH,HeXC,JiSH,SiW,TangXH,LuYQ,ZhouQ,JiWZ*.Theavailabletimewindowforembryotransferintherhesusmonkey(Macacamulatta).AmericanJournalofPrimatology74(2)(2012):165-173.JouneauA,CiaudoC,SismeiroO,BrochardV,JouneauL,Vandormeal-PourninS,CoppeeJY,ZhouQ,HeardE,AntoniewskiC,Cohen-TannoudjiM*.NaiveandprimedmurinepluripotentstemcellshavedistinctmiRNAexpressionprofiles.RNA18(2)(2012):253-264.2011年度:
TongM#,LvZ#,LiuL#,ZhuH#,ZhengQY#,ZhaoXY,LiW,WuYB,ZhangHJ,WuHJ,LiZK,ZengFY,WangL,WangXJ,ShaJH*,ZhouQ*.MicegeneratedfromtetraploidcomplementationcompetentiPScellsshowsimilardevelopmentalfeaturesasthosefromEScellsbutarepronetotumorigenesis.CellResearch21(11)(2011):1634-1637.(封面文章)HaiT#,HaoJ#,WangL,JouneauA*,ZhouQ*.Pluripotencymaintenanceinmousesomaticcellnucleartransferembryosandits3improvementbytreatmentwiththehistonedeacetylaseinhibitorTSA.CellularReprogramming13(1)(2011):47-56.RiazA#,ZhaoXY#,DaiXP#,LiW,LiuL,WanHF,YuY,WangL,ZhouQ*.Mousecloningandsomaticcellreprogrammingusingelectrofusedblastomeres.CellResearch21(5)(2011):770-778.YuY#,YanJ#,LiuZC#,YanLY,LiM,ZhouQ*,QiaoJ*.Optimaltimingofoocytematurationanditsrelationshipwiththespindleassemblyanddevelopmentalcompetenceofinvitromaturedhumanoocytes.FertilityandSterility96(1)(2011):73-78.RiazA,JaveedA*,ZhouQ.Therapeuticcloningbyxenotransplantedoocytes,supplementedwithspeciesspecificreprogrammingfactors.MedicalHypotheses76(4)(2011):527-529.LiW#,ZhaoXY#,WanHF,ZhangY,LiuL,LvZ,WangXJ,WangL*,ZhouQ*.iPScellsgeneratedwithoutc-MychaveactiveDlk1-Dio3regionandarecapableofproducingfull-termmicethroughtetraploidcomplementation.CellResearch21(3)(2011):550-553.YuanX#,WanHF#,ZhaoXY,ZhuSY,ZhouQ,DingS*.CombinedChemicalTreatmentEnablesOct4-InducedReprogrammingfromMouseEmbryonicFibroblasts.StemCells29(3)(2011):549-553.2010年度:
NiuYY#,YuY#,BernatA#,YangSH,HeXC,GuoXY,ChenDL,ChenYC,JiSH,SiW,LvYQ,TanT,WeiQ,WangH,ShiL,GuanJ,ZhuXM,AfanassieffM,SavatierP*,ZhangK*,ZhouQ*,JiWZ*.Transgenicrhesusmonkeysproducedbygenetransferintoearly-cleavage–stageembryosusingasimianimmunodeficiencyvirus-basedvector.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica107(41)(2010):17663-17667.
?获得中国首例转基因猕猴ZhaoXY,LiW,LvZ,ZengFY*,ZhouQ*.ProductionofmiceusingiPScellsandtetraploidcomplementation.NatureProtocols5(5)(2010):963-971.LiuL#,LuoGZ#,YangW#,ZhaoXY#,ZhengQY,LvZ,LiW,WuHJ,WangL,WangXJ*,ZhouQ*.ActivationoftheimprintedDlk1-Dio3regioncorrelateswithpluripotencylevelsofmousestemcells.JournalofBiologicalChemistry285(25)(2010):19483-19490.
?封面文章,被ScienceDaily等媒体报道
http://www.sciencedaily.com/releases/2010/04/100416094016.htmZhaoXY#,LiW#,LvZ#,LiuL,TongM,HaiT,HaoJ,WangX,WangL,ZengFY*,ZhouQ*.ViablefertilemicegeneratedfromfullypluripotentiPScellsderivedfromadultsomaticcells.StemCellReviewsandReports6(3)(2010):390-397.DaiXP#,HaoJ#,HouXJ#,HaiT,FanY,YuY,JouneauA,WangL,ZhouQ*.Somaticnucleusreprogrammingissignificantlyimprovedbym-carboxycinnamicacidbishydroxamide(CBHA),ahistonedeacetylaseinhibitor.JournalofBiologicalChemistry285(40)(2010):31002-31010.ZhouSY#,DingCH#,ZhaoXY#,WangEY,DaiXP,LiuL,LiW,LiuZC,WanHF,FengCJ,HaiH,WangL,ZhouQ*.Successfulgenerationofclonedmiceusingnucleartransferfrominducedpluripotentstemcells.CellResearch20(7)(2010):850-853.WangYY,HaiT,LiuZC,ZhouSY,LvZ,DingCH,LiuL,NiuYY,ZhaoXY,TongM,WangL,JouneauA,ZhangX,JiWZ*,ZhouQ*.HSPC117deficiencyinclonedembryoscausesplacentalabnormalityandfetaldeath.BiochemicalandBiophysicalResearchCommunications397(2010):407–412.MaruottiJ#,DaiXP#,BrochardV,JouneauL,LiuJ,Bonnet-GarnierA,JammesH,VallierL,BronsIG,PedersenR,RenardJP,ZhouQ*,JouneauA*.Nucleartransfer-derivedepiblaststemcellsaretranscriptionallyandepigeneticallydistinguishablefromtheirfertilized-derivedcounterparts.StemCells28(4)(2010):743-752.ZhaoXY,LvZ,LiuL,WangL,TongM,ZhouQ*.DerivationofembryonicstemcellsfromBrownNorwayratsblastocysts.JournalofGeneticsandGenomics37(7)(2010):467-473.LiZK,ZhouQ*.Cellularmodelsfordiseaseexploringanddrugscreening.Protein&Cell1(4)(2010):355-362.ZhaoXY#,LiW#,LvZ#,LiuL,TongM,HaiT,HaoJ,GuoCL,WangX,WangL,ZengFY*,ZhouQ*.Efficientandrapidgenerationofinducedpluripotentstemcellsusingalternativeculturemedium.CellResearch20(3)(2010):383-386.LuZY#,ZhuWW#,YuY#,JinD,GuanYQ,YaoRQ,ZhangY,ZhangYS,ZhouQ*.Derivationandlong-termcultureofhumanparthenogeneticembryonicstemcellsusinghumanforeskinfeeders.JournalofAssistedReproductionandGenetics27(6)(2010):285-291.2009年度:
ZhaoXY#,LiW#,LvZ#,LiuL,TongM,HaiT,HaoJ,GuoCL,MaQW,WangL,ZengFY*,ZhouQ*.iPScellsproduceviablemicethroughtetraploidcomplementation.Nature461(7260)(2009):86-90.
?2009年入选美国《时代周刊》评选的十大医学突破、中国基础研究十大新闻、两院院士评选的中国十大科技进展DaiXP,HaoJ,ZhouQ*.Amodifiedculturemethodsignificantlyimprovesthedevelopmentofmousesomaticcellnucleartransferembryos.Reproduction138(2)(2009):301-308.YuY#,MaiQY#,ChenXJ#,WangL,GaoL,ZhouCQ*,ZhouQ*.Assessmentofthedevelopmentalcompetenceofhumansomaticcellnucleartransferembryosbyoocytemorphologyclassification.HumanReproduction24(3)(2009):649-657.MaMY,ZhouL,GuoXJ,LvZ,YuY,DingCH,ZhangP,BiY,XieJ,WangL,LinM,ZhouZM,HuoR*,ShaJH,ZhouQ*.Decreasedcofilin1expressionisimportantforcompactionduringearlymouseembryodevelopment.BiochimicaetBiophysicaActa1793(12)(2009):1804-1810.ChenXJ#,LiTQ#,LiXM#,XieYH,GuoXY,JiSH,NiuYY,YuY,DingCH,YaoRQ,YangSH,JiWZ,ZhouQ*.Neuralprogenitorsderivedfrommonkeyembryonicstemcellsinasimplemonoculturesystem.ReproductiveBioMedicineOnline19(3)(2009):426-433.HaoJ,ZhuWW,ShengC,YuY,ZhouQ*.Humanparthenogeneticembryonicstemcells:onepotentialresourceforcelltherapy.ScienceinChinaSeriesC:LifeSciences52(7)(2009):599-602.YuY#,WuJD#,FanY,LvZ,GuoXJ,ZhaoC,ZhouR,ZhangZ,WangFQ,XiaoM,ChenL,ZhuH,ChenW,LinM,LiuJY,ZhouZM,WangL,HuoH*,ZhouQ*,ShaJH.Evaluationofblastomerebiopsyusingmousemodelindicatesthepotentialhigh-riskofneurodegenerativedisordersintheoffspring.Molecular&CellularProteomics8(7)(2009):1490-1500.JinLF#,JiSH#,TangXH,GuoXJ,LuYQ,ChenHW,DengHK,ZhouQ*,JiWZ*.Isolationandcharacterizationofliverepithelialprogenitorcellsfromnormaladultrhesusmonkeys(Macacamulatta).CellResearch19(2)(2009):268-270.YangSH#,HeX#,NiuYY,HildebrandtTB,JewgenowK,GoeritzF,TangX,ChangY,ZhouQ,JiWZ*.Ovarianresponsetogonadotropinstimulationinjuvenilerhesusmonkeys.Theriogenology72(2)(2009):243-250.2008年度:
NiuYY#,YangSH#,YuY#,DingCH,YangFJ,WangSF,JiSH,HeXC,XieYH,TangXH,ZhouQ*,JiWZ*.Impairmentsinembryonicgenomeactivationinrhesusmonkeysomaticcellnucleartransferembryos.CloningandStemCells10(1)(2008):25-36.MaMY#,GuoXJ#,WangFQ,ZhaoC,LiuZC,ShiZH,WangYF,ZhangP,ZhangKM,WangNL,LinM,ZhouZM,LiuJY,LiQZ,WangL,HuoR*,ShaJH,ZhouQ*.Proteinexpressionprofileofthemousemetaphase-IIoocyte.JournalofProteomeResearch7(11)(2008):4821-4830.WangSF#,ShenY#,YuanXH,ChenK,GuoXY,ChenYC,NiuYY,LiJ,XuRH,YanXY*,ZhouQ*,JiWZ*.Dissectingsignalingpathwaysthatgovernself-renewalofrabbitembryonicstemcells.JournalofBiologicalChemistry283(51)(2008):35929-35940.FanY,TongM,ZhaoCL,DingCH,HaoJ,LvZ,DaiXP,HaiT,LiXM,YaoRQ,YuY,LiZD,WangL,AliceJ,Zhou,Q*.Comparativepluripotencyanalysisofmouseembryonicstemcellsderivedfromwild-typeandinfertilehermaphroditesomaticcellnucleartransferblastocysts.ChineseScienceBulletin53(23)(2008):3648-3655.YangSH#,ShenY#,NiuYY,HildebrandtTB,JewgenowK,GoeritzF,HeX,ZhouQ,JiWZ*.EffectsofrhFSHregimenandtimeintervalonovarianresponsestorepeatedstimulationcyclesinrhesusmonkeysduringaphysiologicbreedingseason.Theriogenology70(1)(2008):108-114.2007年度:
YuY#,DingCH#,WangEY,ChenXJ,LiXM,ZhaoCL,FanY,WangL,BeaujeanN,ZhouQ,JouneauA*,JiWZ*.Piezo-assistednucleartransferaffectscloningefficiencyandmaycauseapoptosis.Reproduction133(5)(2007):947-954.YangSH*,HeXC,HildebrandtTB,JewgenowK,GoeritzF,TangX,ZhouQ*,JiWZ*.EffectsofrhFSHdoseonovarianfollicularresponse,oocyterecoveryandembryodevelopmentinrhesusmonkeys.Theriogenology67(6)(2007):1194-1201.MaiQY#,YuY#,LiT,WangL,ChenMJ,HuangSZ*,ZhouCQ*,ZhouQ*.Derivationofhumanembryonicstemcelllinesfromparthenogeneticblastocysts.CellResearch17(12)(2007):1008-1019.MitalipovSM*,ZhouQ,ByrneJA,JiWZ,NorgrenRB,WolfDP.Reprogrammingfollowingsomaticcellnucleartransferinprimatesisdependentuponnuclearremodeling.HumanReproduction22(8)(2007):2232-2242.YangSH,HeXC,HildebrandtTB,ZhouQ,JiWZ*.Superovulatoryresponsetoalowdosesingle-dailytreatmentofrhFSHdissolvedinpolyvinylpyrrolidoneinrhesusmonkeys.AmericanJournalofPrimatology69(11)(2007):1278-1284.WangSF,TangXH,NiuYY,ChenHW,LiB,LiTQ,ZhangXZ,HuZX,ZhouQ,JiWZ*.Generationandcharacterizationofrabbitembryonicstemcells.StemCells25(2)(2007):481-489.YangJF,YangSH,BeaujeanN,NiuYY,HeXC,XieYH,TangXH,WangL,ZhouQ*,JiWZ*.Epigeneticmarksinclonedrhesusmonkeyembryos:comparisonwithcounterpartsproducedinvitro.BiologyofReproduction76(1)(2007):36-42.ZhaoCL#,YaoRQ#,HaoJ,DingCH,FanY,DaiXP,LiW,HaiT,LiuZC,YuY,WangYY,HouXJ,JiWZ,ZhouQ,JouneauA,ZengFY*,WangL*.Establishmentofcustomizedmousestemcelllinesbysequentialnucleartransfer.CellResearch17(1)(2007):80-87.2006年度:
ZhouQ*,YangSH#,DingCH#,HeXC,XieYH,HildebrandtB,MitalipovM,TangXH,WolfDP*,JiWZ*.Acomparativeapproachtosomaticcellnucleartransferintherhesusmonkey.HumanReproduction21(10)(2006):2564-2571.LiZY,SunXS,ChenJ,LiuXM,WiselySM,ZhouQ,RenardJP,LenoGH,EngelhardtJF*.Clonedferretsproducedbysomaticcellnucleartransfer.DevelopmentalBiology293(2)(2006):439-448.JouneauA*,ZhouQ,CamusA,BrochardV,MaulnyL,CollignonJ,RenardJP*.DevelopmentalabnormalitiesofNTmouseembryosappearearlyafterimplantation.Development133(8)(2006):1597-1607.2005年度:
LiTQ,WangSF,XieYH,LuYQ,ZhangXZ,WangL,YangSH,WolfD,ZhouQ*,JiWZ*.Transplantableneuralprogenitorpopulationsderivedfromrhesusmonkeyembryonicstemcells.StemCells23(9)(2005):1295-1303.LiTQ,WangSF,XieYH,LuYQ,ZhangXZ,WangL,YangSH,WolfD,ZhouQ*,JiWZ*.Homologousfeedercellssupportundifferentiatedgrowthandpluripotencyinmonkeyembryonicstemcells.StemCells23(8)(2005):1192-1199.LiZY*,ChenX,SunXS,ZhouQ,ChenJ,LenoGH,EngelhardtJF.NucleartransferofM-phaseferretfibroblastssynchronizedwiththemicrotubuleinhibitordemecolcine.JournalofExperimentalZoology303(12)(2005):1126-1134.2003年度:
ZhouQ,RenardJP*,LeFriecG,BrochardV,BeaujeanN,CherifiY,FraichardA,CozziJ.Generationoffertileclonedratsbyregulatingoocyteactivation.Science302(5648)(2003):1179.
?受到Nature,Science等杂志评价,并因此获得国际转基因研究genOway奖、入选2003年中国十大科技新闻人物
http://news.sciencemag.org/sciencenow/2003/09/25-01.htmlChristiansEC,ZhouQ,RenardJP,BenjaminIJ.Heatshockproteinsinmammaliandevelopment.SeminarsinCell&DevelopmentalBiology14(2003):283-290.LiZY,SabetMR,ZhouQ,LiuXM,DingW,ZhangYL,RenardJP,EngelhardtJF*.DevelopmentalcapacityofferretembryosbynucleartransferusingG0/G1-phasefetalfibroblasts.BiologyofReproduction68(6)(2003):2297-2303.2002年度:
RenardJP,ZhouQ,LeBourhisD,HeymanY,Chavatte-PalmerP,HueIandVignonX.Nucleartransfertechnologies:Betweensuccessesanddoubts.Theriogenology57(1)(2002):203-222.HeymanY*,ZhouQ,LebourhisD,Chavatte-PalmerP,RenardJP,VignonX.Novelapproachesandhurdlestosomaticcloningincattle.CloningandStemCells4(1)(2002):47-55.VignonX,ZhouQ,RenardJP*.Chromatinasaregulativearchitectureoftheearlydevelopmentalfunctionsofmammalianembryosafterfertilizationornucleartransfer.CloningandStemCells4(4)(2002):363-377.2001年度:
ZhouQ,JouneauA,BrochardV,AdenotP,RenardJP*.Developmentalpotentialofmouseembryosreconstructedfrommetaphaseembryonicstemcellnuclei.BiologyofReproduction65(2)(2001):412-419.2000年度:
ZhouQ,BoulangerL,RenardJP*.Asimplifiedmethodforthereconstructionoffullycompetentmousezygotesfromadultsomaticdonornuclei.Cloning2(1)(2000):35-44.
?1999年被“克隆羊之父”Wilmut教授评价为“克隆领域迄今为止最重要的文章之一”著作:
LiuZC,ZhouSY,ZhangS,XiaBL,ZhouQ.“FrontiersInPluripotentStemCellsResearchandTherapeuticPotentials:Bench-to-Bedside”.Chapter“TherapeuticCloning:DerivationandPropagationofEmbryonicStemCellsbySomaticCellNuclearTransfer”,BenthamScience.2012,Sharjah,U.A.E.ZengFandZhouQ.“StemCells&RegenerativeMedicine-FromMolecularEmbryologytoTissueEngineering”,Chapter“InducedPluripotentStemCells:OntheRoadTowardClinicalApplications”,HumanaPress,SpringerScience&BusinessMedia,2011,NewYorkCity,U.S.A.于洋、王柳、刘蕾、李伟、周舒雅、董明珠、周琪。撰写《再生医学——理论与技术》中的《克隆技术与细胞重编程技术》章节,科学出版社,2010年周琪、刘春巧、霍妍丽。《神秘的克隆》,中国教育科学出版社,1997年写给考生的话: 学而不思则罔,思而不学则殆。—《论语》
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