姓　　名:
孟安明
学　　科:
细胞生物学
电话/传真:
+86-10-64807213/+86-10-64807099
电子邮件:
mengam@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所生物膜与膜生物工程国家重点实验室100101
更多信息:
胚胎发育信号转导研究组

简历：
　　2000年获得国家杰出青年基金、香港求是基金会“杰出青年学者奖”、教育部跨世纪人才基金、教育部优秀青年教师奖，2001年入选第四批教育部****计划特聘教授，2007年获得何梁何利基金科学与技术进步奖。
　　1979.9－1983.7，西南农业大学农学系本科生；
　　1983.8－1987.5，中国水稻研究所实习研究员；
　　1987.5－1990.11，英国诺丁汉大学遗传系博士生；
　　1990.12－1998.8，先后在北京农业大学（现中国农业大学）做博士后研究和任副教授；
　　1996.3－1998.8，在美国佐治亚医学院做访问研究；
　　1998.9以来，清华大学生物系教授；
　　2008.3－中国科学院动物研究所研究员。

研究领域：
　　主要利用斑马鱼为模式动物，结合分子生物学、细胞生物学、遗传学等技术，研究TGF-β/Nodal等重要信号通路在胚胎发育中的作用及分子机制，以及microRNA在斑马鱼早期胚胎发育中的功能。

社会任职：
　　现任中国动物学会副理事长，CurrentZoology主编、BMCDevelopmentalBiology副主编、JCS和JBC编委会成员。

获奖及荣誉：
　　2000年获得国家杰出青年基金、香港求是基金会“杰出青年学者奖”、教育部跨世纪人才基金、教育部优秀青年教师奖，2001年入选第四批教育部****计划特聘教授，2007年获得何梁何利基金科学与技术进步奖。
承担科研项目情况：
代表论著：

1. Liu,X.,Ning,G.,Meng,A.M.,andWang,Q.(2012).MicroRNA-206RegulatesCellMovementsduringZebrafishGastrulationbyTargetingprickle1aandRegulatingc-JunN-TerminalKinase2Phosphorylation.MolCellBiol32,2934-2942.
   
2. Jia,S.,Dai,F.,Wu,D.,Lin,X.,Xing,C.,Xue,Y.,Wang,Y.,Xiao,M.,Wu,W.,Feng,X.H.,andMeng,A.M.(2012).Proteinphosphatase4cooperateswithSmadstopromoteBMPsignalingindorsoventralpatterningofzebrafishembryos.DevCell22,1065-1078.
   
3. Wang,Y.,Li,Z.,Xu,P.,Huang,L.,Tong,J.,Huang,H.,andMeng,A.M.(2011).Angiomotin-like2gene(amotl2)isrequiredformigrationandproliferationofendothelialcellsduringangiogenesis.JBiolChem286,41095-41104.
   
4. Liu,Z.,Lin,X.,Cai,Z.,Zhang,Z.,Han,C.,Jia,S.,Meng,A.M.,andWang,Q.(2011).GlobalidentificationofSMAD2targetgenesrevealsaroleformultipleco-regulatoryfactorsinzebrafishearlygastrulas.JBiolChem286,28520-28532.
   
5. Han,Y.,Mu,Y.,Li,X.,Xu,P.,Tong,J.,Liu,Z.,Ma,T.,Zeng,G.,Yang,S.,Du,J.,andMeng,A.M.(2011).Grhl2deficiencyimpairsoticdevelopmentandhearingabilityinazebrafishmodeloftheprogressivedominanthearinglossDFNA28.HumMolGenet20,3213-3226.
   
6. Zhao,X.,Zhao,L.,Tian,T.,Zhang,Y.,Tong,J.,Zheng,X.,andMeng,A.M.(2010).Interruptionofcenphcausesmitoticfailureandembryonicdeath,anditshaploinsufficiencysuppressescancerinzebrafish.JBiolChem285,27924-27934.
   
7. Zhang,Y.,Li,X.,Qi,J.,Wang,J.,Liu,X.,Zhang,H.,Lin,S.C.,andMeng,A.M.(2009).Rock2controlsTGFbetasignalingandinhibitsmesoderminductioninzebrafishembryos.JCellSci122,2197-2207.
   
8. Li,X.,Jia,S.,Wang,S.,Wang,Y.,andMeng,A.M.(2009).Mta3-NuRDcomplexisamasterregulatorforinitiationofprimitivehematopoiesisinvertebrateembryos.Blood114,5464-5472.
   
9. Jia,S.,Wu,D.,Xing,C.,andMeng,A.M.(2009).Smad2/3activitiesarerequiredforinductionandpatterningoftheneuroectoderminzebrafish.DevBiol333,273-284.
   
10. Zhao,L.,Zhao,X.,Tian,T.,Lu,Q.,Skrbo-Larssen,N.,Wu,D.,Kuang,Z.,Zheng,X.,Han,Y.,Yang,S.,Zhang,C.,andMeng,A.M.(2008).Heart-specificisoformoftropomyosin4isessentialforheartbeatinzebrafishembryos.CardiovascRes80,200-208.
    
11. Meng,F.,Cheng,X.,Yang,L.,Hou,N.,Yang,X.,andMeng,A.M.(2008).Acceleratedre-epithelializationinDpr2-deficientmiceisassociatedwithenhancedresponsetoTGFbetasignaling.JCellSci121,2904-2912.
    
12. Jia,S.,Ren,Z.,Li,X.,Zheng,Y.,andMeng,A.M.(2008).smad2andsmad3arerequiredformesendoderminductionbytransforminggrowthfactor-beta/nodalsignalsinzebrafish.JBiolChem283,2418-2426.
    
13. Su,Y.,Zhang,L.,Gao,X.,Meng,F.,Wen,J.,Zhou,H.,Meng,A.M.,andChen,Y.G.(2007).TheevolutionallyconservedactivityofDapper2inantagonizingTGF-betasignaling.FASEBJ21,682-690.
    
14. Rui,Y.,Xu,Z.,Xiong,B.,Cao,Y.,Lin,S.,Zhang,M.,Chan,S.C.,Luo,W.,Han,Y.,Lu,Z.,YeZ.,ZhouH.,HanJ.,MengA.M.,LinS.(2007).Abeta-catenin-independentdorsalizationpathwayactivatedbyAxin/JNKsignalingandantagonizedbyaida.DevCell13,268-282.
    
15. Huang,H.,Lu,F.I.,Jia,S.,Meng,S.,Cao,Y.,Wang,Y.,Ma,W.,Yin,K.,Wen,Z.,Peng,J.,ThisseC.,ThisseB.,MengA.M.(2007).Amotl2isessentialforcellmovementsinzebrafishembryoandregulatesc-Srctranslocation.Development134,979-988.
    
16. Xiong,B.,Rui,Y.,Zhang,M.,Shi,K.,Jia,S.,Tian,T.,Yin,K.,Huang,H.,Lin,S.,ZhaoX.,ChenY.,ChenY.G.,LinS.C.,MengA.M.(2006).Tob1controlsdorsaldevelopmentofzebrafishembryosbyantagonizingmaternalbeta-catenintranscriptionalactivity.DevCell11,225-238.
    
17. Lin,X.,Duan,X.,Liang,Y.Y.,Su,Y.,Wrighton,K.H.,Long,J.,Hu,M.,Davis,C.M.,Wang,J.,Brunicardi,F.C.,ShiY.G.,ChenY.G.,MengA.M.,FengX.(2006).PPM1AfunctionsasaSmadphosphatasetoterminateTGFbetasignaling.Cell125,915-928.
    
18. Zhang,L.,Zhou,H.,Su,Y.,Sun,Z.,Zhang,H.,Zhang,Y.,Ning,Y.,Chen,Y.G.,andMeng,A.M.(2004).ZebrafishDpr2inhibitsmesoderminductionbypromotingdegradationofnodalreceptors.Science306,114-117.
    
19. Penberthy,W.T.,Zhao,C.,Zhang,Y.,Jessen,J.R.,Yang,Z.,Bricaud,O.,Collazo,A.,Meng,A.M.,andLin,S.(2004).PuralphaandSp8asopposingregulatorsofneuralgata2expression.DevBiol275,225-234.
    
20. Cao,Y.,Zhao,J.,Sun,Z.,Zhao,Z.,Postlethwait,J.,andMeng,A.M.(2004).fgf17b,anovelmemberofFgffamily,helpspatterningzebrafishembryos.DevBiol271,130-143.
    
21. Zhao,J.,Cao,Y.,Zhao,C.,Postlethwait,J.,andMeng,A.M.(2003).AnSP1-liketranscriptionfactorSpr2actsdownstreamofFgfsignalingtomediatemesoderminduction.EMBOJ22,6078-6088.
    
22. Zhao,Z.,Cao,Y.,Li,M.,andMeng,A.M.(2001).Double-strandedRNAinjectionproducesnonspecificdefectsinzebrafish.DevBiol229,215-223.
    
23. Zhang,L.,Hua,Z.,Ren,J.,andMeng,A.M.(2001).ThenuclearlocalizationsignalofzebrafishterraislocatedwithintheDMdomain.FEBSLett503,25-29.
    
24. Meng,A.M.,Tang,H.,Yuan,B.,Ong,B.A.,Long,Q.,andLin,S.(1999).Positiveandnegativecis-actingelementsarerequiredforhematopoieticexpressionofzebrafishGATA-1.Blood93,500-508.
    
25. Meng,A.M.,Moore,B.,Tang,H.,Yuan,B.,andLin,S.(1999).ADrosophiladoublesex-relatedgene,terra,isinvolvedinsomitogenesisinvertebrates.Development126,1259-1268.
    
26. Meng,A.M.,Jessen,J.R.,andLin,S.(1999).Transgenesis.MethodsCellBiol60,133-148.
    
27. Jessen,J.R.,Meng,A.M.,McFarlane,R.J.,Paw,B.H.,Zon,L.I.,Smith,G.R.,andLin,S.(1998).Modificationofbacterialartificialchromosomesthroughchi-stimulatedhomologousrecombinationanditsapplicationinzebrafishtransgenesis.ProcNatlAcadSciUSA95,5121-5126.
    
28. Meng,A.M.,Tang,H.,Ong,B.A.,Farrell,M.J.,andLin,S.(1997).Promoteranalysisinlivingzebrafishembryosidentifiesacis-actingmotifrequiredforneuronalexpressionofGATA-2.ProcNatlAcadSciUSA94,6267-6272.
    

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