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中国科学院动物研究所研究生导师简介-赵　勇

动物研究所 免费考研网/2013-11-29

姓　　名:
赵　勇
学　　科:
细胞生物学
电话/传真:
+86-10-64807302/+86-10-64807313
电子邮件:
zhaoy@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所生物膜与膜生物工程国家重点实验室100101
更多信息:
移植生物学研究组

简历：
　　赵勇，男，博士，研究员，博士生导师；中科院动物研究所生物膜与膜生物工程国家重点实验室副主任，移植生物学研究组组长。
　　国家杰出青年基金及新世纪百千万人才工程国家级人选获得者。于2003年4月为中科院“百人计划”国外引进杰出人才项目回国，建立移植生物学实验室，现有工作人员4人，博士后8人，博士/硕士生10余人。主要应用移植动物模型、基因工程改造动物及分子生物学技术，探讨T细胞移植免疫耐受及免疫应答调控的分子机制，建立移植免疫耐受的诱导方案，开发组织细胞工程产品及基因工程药物。此外，通过比较同种异种移植免疫排斥反应的异同，为寻找克服异种移植免疫排斥的有效途径提供指导。在国际学术刊物（如NatureMedicine、JofImmunology、Transplantation、AmericanJournalofTransplantation、JofMolMed及Xenotransplantation等）上发表学术论文150余篇，主编《异种移植免疫学》及《移植免疫耐受》。
　　实验室目前得到中国科学院“百人计划”、国家杰出青年基金、科技部973项目、国家自然基金委重点项目及中科院创新方向性项目等资助。实验室现已毕业博士/硕士研究生30余名。博士研究生毕业去向主要为在美国等出国留学，硕士研究生主要从事国家公务员、企业工作。
　　1993年7月在白求恩医科大学获生物学(免疫学)博士；
　　1993年8月－1995年3月日本东京三菱化成生命科学研究所任特别研究员；
　　1995年3月－2000年5月在哈佛大学/麻省总医院移植生物学研究中心博士后；
　　2000年5月起至2003年8月任美国内布拉斯加大学医学院，外科兼病理与微生物科助理教授；
　　2003年8月－，中科院动物所研究员，博士导师　　

研究领域：
　　主要从事同种/异种移植免疫排斥反应及T细胞免疫耐受的诱导及其分子机制、抑制性T细胞的诱导与应用、胸腺发育分化的分子调节、巨噬细胞生物学等免疫学领域的研究。

社会任职：
　　现为国际移植学会、美国免疫学会会员，中国生物工程学会、中国免疫学会理事，动物学杂志副主编，ExpertReviewofClinicalImmunology、Cellular&MolecularImmunologyEditor。

获奖及荣誉：
承担科研项目情况：
  • 国家重点基础研究发展计划：胸腺与免疫细胞发育的分子调控
  • 科技部重大专项：艾滋病病人的疾病进展相关因素的研究
  • 杰出青年基金项目：移植免疫学
  • 国家自然基金重点项目：混合嵌合体小鼠巨噬细胞免疫耐受特征及其分子机制研究
  • 国家自然科学基金面上项目：TSC1对T细胞发育分化的免疫调节效应
  • 国家基金委与广东省联合基金重点项目：凋亡细胞诱导移植免疫耐受的研究
  • 中科院创新项目：胸腺上皮前体（干）细胞的特异标志筛选及鉴定


代表论著：
  1. 赵勇主编.2003.异种移植免疫学.中国医药科技出版社.中国:北京.
  2. 赵勇主编.2005.移植免疫耐受.中国医药科技出版社.中国:北京.
  3. SunLN,LiHR,LuoHY,andZhaoY.*Thymicepithelialcelldevelopmentanddifferentiation:Cellularandmolecularregulations.2013(Submitted).
  4. ChenH,ZhangLJ,ZhangHB,LiL,XiaoY,SunLN,LiH,CorleyD,LiuG,YangZZ,andZhaoY*TSC1/2complexnegativelyregulatesthymicCD4+CD25+Foxp3+Tregdevelopmentinmice.2013(Submitted)
  5. HouY,LinH,DuanK,ZhuL,LiuZ,HuF,ShiJ,RaoE,YangT,ShiX,YinZ,ZhuM,ZhangL,GodleyF.B.,WangQ*,LiZ*,andZhaoY*TLRligandsandIFN-γantagonisticallyorchestratetheproteaseHTRA1expressioninrheumatoidarthritis.2013(submitted).
  6. LiuG,HuX,SunB,ShiJ,ZhangL*,andZhaoY.*PhosphataseWip1NegativelyRegulatesNeutrophilDevelopmentthroughp38MAPK-STAT1.Blood2013121(3):519-529.
  7. WuT,SunC,ChenZ,ZhenY,PengJ,QiZ.,YangX.,andZhaoY*Smad3-deficientCD11b+Gr1+myeloid-derivedsuppressorcellspreventallograftrejectionviathenitricoxidepathwayJournalofImmunology2012189(10):4989-5000.
  8. HuX,LiuG,HouY,ShiJ,ZhuL,JinD,PengJ,andZhaoY*InductionofrecipientM2macrophagesbyallogeneicdonorregulatoryCD4+CD25+TcellsinmiceCellMolImmunol20129(6):464-472.
  9. SunC.,JiangY.,SunL.,ShangH.*,andZhaoY.*ThecharacteristicsofTh1/Th2cytokinereceptorsonmonocytesinuntreatedpatientsoflongtermnonprogressororchronicHIVinfection.CurrentMoleculeMedicine.201212(8):1028-1039.
  10. Wu,T.,Zhang,L.,Xu,K.,Sun,C.,Lei,T.,Peng,J.,Liu,G.,Wang,R.,ZhaoY*,ImmunosuppressivedrugsoninducingAg-specificCD4+CD25+Foxp3+Tregcellsduringimmuneresponseinvivo.TransplantImmunology,2012,27(1):30-38
  11. Huang,L.,Wang,Z.B.Jiang,Z.Z.Hu,M.W.Lin,F.,Zhang,Q.H.,Luo,Y.B.,Hou,Y.,Zhao,Y.,Fan,H.Y.,Schatten,H.SpecificdisruptionofTsc1inovariangranulosacellspromotesovulationandcausesprogressiveaccumulationofcorporalutea.PLoSOne2012,8(1):e54052.
  12. Y.Liu,X.,Ma,B.,Malik,A.B.,Tang,H.,Yang,T.,Sun,B.,Wang,G.,Minshall,R.D.,Li,Y.,Zhao,Y.,Ye,R.D.,andXu,J.*Bidirectionalregulationofneutrophilmigrationbymitogen-activatedproteinkinasesNatureImmunology2012,13(5):457-464.
  13. Y.ZhangL,LiL,XiaoY,RaoE,MiaoZ,ChenH,SunL,LiH,ZhangHandZhaoY*TSC1/2pathwaycriticallyregulatesperipheralnaiveCD8+TcellsurvivalandhomeostasisinmicePLoSOne2012,7(2):e30592.
  14. Jin,D.,Duan,K.,Zhang,L.,Peng,J.,andZhao,Y.*TheeffectsofleflunomideonCD4+CD25+Foxp3+Tregulatorycellsinmicereceivingallogeneicbonemarrowtransplantation.InflammationResearch2012,61(1):53-60.
  15. ZengC,ShiX,ZhangB,LiuH,ZhangL,DingW,andZhaoY*TheimbalanceofTh17/Th1/Tregsinpatientswithtype2diabetes:Relationshipwithmetabolicfactorsandcomplications.JMolecularMedicine2012,90(2):175-186.
  16. Zhen,Y.,Sun,L.,Liu,H.,Duan,K.,Zeng,C.,Zhang,L.,Jin,D.,Peng,J.,Ding,W.*,andZhao,Y.*AlterationsofperipheralCD4+CD25+Foxp3+TregulatorycellsinmicewithSTZ-induceddiabetes.CellMolImmunol2012,9(1):75-85.
  17. SunC,SunL,MaH,PengJ,ZhenY,DuanK,LiuG,DingW*andZhaoY.*ThephenotypeandfunctionalalterationsofmacrophagesinmicewithhyperglycemiaforlongtermJofCellPhysiology2012,227(4):1670-1679.
  18. DuanK,ZhangB,ZhangW,ZhaoY,QuY,SunC,andZhaoY*EfficientperipheralconstructionoffunctionalhumanregulatoryCD4+CD25highFoxp3+TcellsinNOD/SCIDmicegraftedwithfetalhumanthymus/livertissuesandCD34+cellsTransplImmunol2011,25(4):173-179.
  19. LiuG,DuanK,MaH,NiuZ,PengJ,andZhaoY*AninstructiveroleofdonormacrophagesinmixedchimerasintheinductionofCD4+Foxp3+Tregcells.ImmunologyandCellBiology2011,89(8):827-835.
  20. LaiL*,CuiC,JinJ,HaoZ,ZhengQ,YingM,BoydR,andZhaoYMouseembryonicstemcell-derivedthymicepithelialcellprogenitorsenhanceT-cellreconstitutionafterallogeneicbonemarrowtransplantationBlood2011;118(12):3410-3418
  21. JaveedA,HouY,DuanK,ZhangB,ShenH,CaoY,ZhaoY*.Aspirinsignificantlydecreasesthenonopsonicphagocytosisandimmunogenicityofmacrophagesinmice.InflammationResearch,2011,60(4):389-398..
  22. ZhuS,PeigneurS,GaoB,LuoL,JinD,ZhaoY,Tytgat.JMolecularDiversityandFunctionalEvolutionofScorpionPotassiumChannelToxins.Molecular&CellularPeoreomics2011;10(2):M110.002832
  23. LiuG,ZhangLandZhaoY*.ModulationofimmuneresponsesthroughdirectactivationofToll-likereceptorstoTcells.ClinicalandExperimentalImmunology,2010,160:168-175.
  24. QuY,ZhangB,LiuS,ZhangA,WuT,ZhaoY*.2-Gywhole-bodyirradiationsignificantlyaltersthebalanceofCD4+CD25-TeffectorcellsandCD4(+)CD25(+)Foxp3(+)Tregulatorycellsinmice.Cellular&MolecularImmunology.2010,7(6):419-427.
  25. LiuG,MaH,QiuL,LiL,CaoY,MaJ,ZhaoY*.PhenotypicandfunctionalswitchofmacrophagesinducedbyregulatoryCD4(+)CD25(+)Tcellsinmice.ImmunologyandCellBiology.2010,1–13.
  26. SunY,ZhuZ,LangnasAN,GrantWJ,BothaJF,ZhaoY,SudanDL,MercerDF.Plasmanitriteandnitratelevelsasanoninvasivemarkerofpathologyafterhumansmallboweltransplantation.Transplantation.2010,89(3):307-311.
  27. SunL,GuoJ,BrownR,AmagaiT,ZhaoY,SuDM.Decliningexpressionofasingleepithelialcell-autonomousgeneacceleratesage-relatedthymicinvolution.AgingCell2010,9(3):347-357.
  28. ZhaoY*andLiX*.Cross-immunetolerance:conceptionanditspotentialsignificanceontransplantationtolerance.Cellular&MolecularImmunology2010,7(1):20-25.
  29. LiangH,YangL,MaTandZhaoY*.Functionalexpressionofcysticfibrosistransmembraneconductanceregulationinmousechondrocytes.ClinicalandExperimentalPharmacology&Physiology.2010,37:506-508.
  30. QuYY,ZhangAJ,ZhangBJ,WangJJandZhaoY.*.Gamma-RayResistanceofRegulatoryCD4+CD25+Foxp3+TCellsinmice.RadiationResearch2010,173(2):148-157.
  31. JiangP,RaoEY,MengN,ZhaoY,WangJJ:MicroRNA-17-92significantlyenhancesradioresistanceinhumanmantlecelllymphomacells.RadiationOncology2010,5:100.
  32. ZhangY,WangJ,LiuF,YouZ,YangR,ZhaoY:EGFRinhibitorC225increasestheradiosensitivityofhumanlungsquamouscancercells.CancerCellInternational2010,10:39.
  33. YouZY,ZhaoY,LiuF,ZhangYD,WangJJ:TheradiosensitizationeffectsofEndostaronhumanlungsquamouscancercellsH-520.CancerCellInternational2010,10:17.
  34. WangJ,LiaoA,ZhuangH,ZhaoY:Thedirectbiologiceffectsofradioactive125IseedsonpancreaticcancercellsPANC-1,atcontinuouslow-doserates.CancerBiotherRadiopharm2009,24(4):409-416.
  35. ZhuangHQ,WangJJ,LiaoAY,WangJD,ZhaoY:Thebiologicaleffectof125IseedcontinuouslowdoserateirradiationinCL187cells.JExpClinCancerRes2009,28:12.
  36. LiaoA,WangJ,ZhuangH,ZhaoY.Relativebiologicaleffectivenessandcell-killingefficacyofcontinuouslow-dose-rate125Iseedsonprostatecarcinomacellsinvitro.IntegrCancerTher2010,9:59-65.
  37. ZhengQ,XuY,LiuY,ZhangB,LiX,GuoF,andZhaoY.*.InductionofFoxp3demethylationincreasesregulatoryCD4+CD25+Tcellsandpreventstheoccurrenceofdiabetesinmice.JournalofMolecularMedicine2009,87:1191-1205.
  38. DingC,TianP,JiaL,LiY,DingX,XiangH,XueW,ZhaoY.ThesynergisticeffectsofC.SinensiswithCsAinpreventingallograftrejection.FrontiersinBioscience2009,14:3864-3871.
  39. HuangY,WalstromA,ZhangL,ZhaoY,CuiM,YeLandZhengJ.TypeIinterferonsandinterferonregulatoryfactorsregulateTNF-relatedapoptosis-inducingligand(TRAIL)inHIV-1-infectedmacrophages.2009,PLoSONE4(4):e5397-1-14.
  40. JaveedA.,ZhangB.,QuY.,ZhangA.,SunC.,ZhangL.,LiuJ.,ZengC.,andZhaoY.*.ThesignificantlyenhancedfrequencyoffunctionalCD4+CD25+Foxp3+Tregulatorycellsintherapeuticdoseaspirin-treatedmice.TransplantImmunology2009,20:253-260.
  41. ZhangB.,ZhangA.,QuY.,LiuJ.,NiuZ.,andZhaoY.*.DevelopmentofmouseCD4+CD25+Foxp3+regulatoryTcellsinxenogeneicpigthymicgrafts.TransplantImmunology2009,20:180-185.
  42. ZhangB,DuanZandZhaoY.*.Mousemodelswithhumanimmunityandtheirapplicationinbiomedicalresearch.JournalofCellularandMolecularMedicine2009,13(6):1043-1058.
  43. ZhenY.,ZhengJ.,andZhaoY.*.RegulatoryCD4+CD25+Tcellsandmacrophages:communicationbetweentworegulatorsofeffectorTcells.InflammationResearch2008,57:564-570.
  44. ZhangB.,SunC.,QuY.,ZhangA.,LiuJ.,ZhangL.,NiuZ.,andZhaoY.*.DeficiencyofmouseCD4+CD25+Foxp3+regulatoryTcellsinxenogeneicpigthymus-graftednudemicesufferingfromautoimmunediseases.Cellular&MolecularImmunology2008,5:325-32
  45. WangN，ZhangJS,ZhengQH,ZhaoY.*TheuniquelocalizationofZFP185aturopodofmouseTlymphocytesScandinavianJournalofImmunology2008,67(4):340-344.
  46. YiHF,ZhangJL,andZhaoY.*TheeffectsofantibodytreatmentonregulatoryCD4+CD25+TcellsTransplantImmunology2008,19(1):37-44.
  47. YiH,ZhenY,ZengC,ZhangLJ,andZhaoY.*.Depletinganti-CD4monoclonalantibody(GK1.5)treatment:influenceonregulatoryCD4+CD25+Foxp3+Tcellsinmice.Transplantation2008,85(8):1167-1174.
  48. MaHX,LiuGW,DingWJ,WuY,CaiL,andZhaoY.*.Diabetes-inducedimmunodeficiencyofF4/80+macrophages:astudyinstreptozotocin-inducedtype1diabeticmice.JournalofMolecularMedicine2008,86(4):391-400.
  49. CuiM,HuangYL,ZhaoY.*,andZhengJL*.TranscriptionfactorFoxO3amediatescellapoptosisinHIV-1infectedmacrophages.JournalofImmunology2008,180(2):898-906.
  50. JaveedA.andZhaoY.*.TheeffectsofimmunosuppressiononregulatoryCD4(+)CD25(+)Tcells:impactonimmunosuppressionselectionintransplantation.MolecularDiagnosisandTherapy2008,12:171-181.
  51. JinD.,ZhangL.,ZhengJ.,andZhaoY.*.TheinflammatoryTh17subsetinimmunityagainstselfandnon-selfantigens.Autoimmunity2008,41:154-162.
  52. JaveedA.,andZhaoY.*.MacrophageMigrationInhibitoryFactor:Roleininflammatorydiseasesandgraftrejection.InflammationResearch2007,57(2):45-50.
  53. ZhaoY.*andLiXC.Transplanttolerance:isitreallyfreeofconcerns?TrendsinImmunology2007,28(9):376-377.
  54. WangN,ZhangJS,ZhengQH,ZhaoY.*.Molecularcloningandcharacterizationofanovelmouseactin-bindingproteinZFP185.JournalofMolecularHistology2008,39(3):295-302.
  55. SunLN,andZhaoY*.Thebiologicalroleofdectin-1inimmuneresponseInternationalReviewsofImmunology2007,26:349-364.
  56. Kawahara,T,Rodriguez-Barbosa,J-I,ZhaoY.,Zhao,G,andSykes,M.Globalunresponsivenessasamechanismofnaturalkillercelltoleranceinmixedxenogeneicchimeras.AmericanJournalofTransplantation2007,7(9):2090-2097.
  57. ZhangAJ,QuY,ZhangB,ZhangLJ,ZengC,PengJX,JiXB,HouM,ZhaoY.*.ThedifferenteffectsofindirubinoneffectorandCD4+CD25+regulatoryTcellsinmice：potentialimplicationforthetreatmentofautoimmunediseases.JournalofMolecularMedicine2007,85:1263-1270.
  58. ZhangBJ,ZhangAJandZhaoY.*.Plateletaggregationandthrombosisinxenotransplantationbetweenpigsandhumans.ThrombosisResearch2008,121:433-441.
  59. QuYY.andZhaoY.*.RegulatoryCD4+CD25+Tcellscontrolledbymultiplepathwaysinmultiplelevels.InternationalReviewofImmunology200726(3):145-160.
  60. ZhaoY.*.ThedifferenteffectsofcyclosporinAandrapamycinonregulatoryCD4+CD25+Tcells:potentialrelationshipwithtransplanttoleranceinduction.ExpertReviewofClinicalImmunology2007,3(3):254-259.
  61. LiuGW,MaHX,JiangLL,PengJX,andZhaoY.*TheimmunityofsplenicandperitonealF4/80+residentmacrophagesinmousemixedallogeneicchimeras.JournalofMolecularMedicine2007,85:1125-1135.
  62. YiH,ZhaoY.*.Chemokines,chemokinereceptorsandCD4+CD25+regulatoryTcells.ExpertReviewofClinicalImmunology2007,3(3):343-349.
  63. YiH,ZhangL,ZhenY,HeX,andZhaoY*.DendriticcellsinducedinthepresenceofGM-CSFandIL-5.Cytokine2007,37(1):35-43.
  64. ZhengQHandZhaoY.*.Thediversebio-functionsofLIMdomainproteins:determinedbysub-cellularlocalizationandprotein-proteininteraction.BiologyoftheCell2007,99(9):489-502.
  65. LiuGW,andZhaoY.*.Toll-likereceptorsandimmuneregulation:theirdirectandindirectmodulationonregulatoryCD4+CD25+Tcells.Immunology2007,122:149-156.
  66. WuTH，ZhenY,ZengC,andZhaoY.*.BandTlymphocyteattenuatorinteractswithCD3ζandinhibitsTyrosinephosphorylationofTCRζcomplexduringTcellactivation.ImmunologyandCellBiology2007,85:590-595.
  67. LiuGW,Ma,HX,JiangLL,andZhaoY.*.Allograftinflammatoryfactor-1anditsimmuneregulation.Autoimmunity2007,40(2):95-102.
  68. ZhangLJ,andZhaoY.*.TheregulationofFoxp3expressioninregulatoryCD4+CD25+Tcells:multiplepathwaysontheroad.JournalofCellularPhysiology2007,211(3):590-597.
  69. ZhaoL,WangHJ,SunLG,MaHX,LiuGWandZhaoY.*.ChangesofCD4+CD25+Foxp3+regulatoryTcellsinagedBalb/cmice.JournalofLeukocyteBiology2007,81(6):1386-1394.
  70. ZhangL,SunL,ZhaoY.*.Thymicepithelialprogenitorcellsandthymusregeneration:anupdate.CellResearch2007,17:50-55.
  71. ZengC,YZhen,SShu,TWu,HYi,ZLian,andZhaoY.*.TheinfluenceofcyclosporinAonlymphocyteattenuatorexpression.JournalofAutoimmunity2007,28(4):234-44.
  72. QuY;ZhangB;ZhaoL;LiuG;MaH;ERao;CZeng;andZhaoY.*.TheeffectofimmunosuppressivedrugrapamycinonregulatoryCD4+CD25+Foxp3+Tcellsinmice.TransplantImmunology2007,17:153-161.
  73. ZhaoY.*,SunY,NiuZQ,LiQH,PengJX,WangJJ,andLangnasA.Anovelapproachtogeneratehostanti-tumorTcells:AdoptiveimmunotherapybyTcellsmaturinginxenogeneicthymus.JournalofImmunotherapy2007,30(1):83-88.
  74. LiuGW,MaHX,ZhaoY.WuY,andZhaoY.*.Thenonopsonicallogeneiccellphagocytosisofmacrophagesdetectedbyflowcytometryandtwophotonfluorescencemicroscope.TransplantImmunology2006,16:220-226.
  75. LiuGW,XiaXP,GongSLandZhaoY.*.Themacrophageheterogeneity:differencebetweenmouseperitonealexudatesandsplenicF4/80+macrophages.JournalofCellularPhysiology2006,209:341-352.
  76. ZhaoY.*andLiuGW.Specificimmunetoleranceofantigen-presentingcells:Hypothesisandsignificance.MedicalHypotheses2007,68:404-406.
  77. ZhangBJ,GeB,XiaX,LiuJ,SunLG,RaoEY,andZhaoY.*.CompatibilitybetweenPorcineandHumanIL-2:Implicationforxenotransplantation.Xenotransplantation2006,13:423-432.
  78. WangHJ,ZhaoL,SunZY,SunLG,andZhaoY.*.ApotentialsideeffectofCyclosporinA:itsinhibitiononCD4+CD25+regulatoryTcellsinmice.Transplantation2006,82(11):1484-1492.
  79. Zhao,Y.*.Thetwosimultaneouslyoccurringprocessesinoneimmuneresponse:Thepositiveimmunereactionandimmunetolerance.MedicalHypotheses2006,67(6):1384-1385.
  80. SunZY,WangHJ,SunLG,ZhaoL,YiHF,LiQH,PengJX,andZhaoY.*.PresenceoffunctionalmouseregulatoryCD4+CD25+Tcellsinxenogeneicneonatalporcinethymus-graftedathymicmice.AmericanJournalofTransplantation2006,6(12):2841-2850.
  81. SunYM,YangZ,NiuZ,LiQ,PengJ,LangnasAN.,MaM.Y.,andZhaoY.*.MOP3,acomponentofthemolecularclock,regulatesthedevelopmentofBcells.Immunology2006,119(4):451-460.
  82. SunYM,YangZ,NiuZ,LiQ,PengJ,WangW,MaM.Y.andZhaoY.*.ThemortalityofMOP3deficientmicewithasystemicfunctionalfailure.JournalofBiomedicalScience2006,13:845-851.
  83. LiuGW,WuGL,WuY,andZhaoY.*.Phagocytosisofapoptoticcellsandimmuneregulation.ScandinavianJournalofImmunology2006,64(1):1-9.
  84. ZhangLJ,YiHF,XiaXP,andZhaoY.*.Transforminggrowthfactor-b:animportantroleinCD4+CD25+regulatoryTcellsandimmunetolerance.Autoimmunity2006,39(4):269-276.
  85. LiuGW,WuY,GongSL,andZhaoY.*.Toll-likereceptorsandgraftrejection.TransplantImmunology2006,16:25-31.
  86. YiH.,ZhenY.,JiangL.,ZhengJ.,andZhaoY.*.ThephenotypiccharacterizationofnaturallyoccurringregulatoryCD4+CD25+Tcells.Cellular&MolecularImmunology2006,3(3):189-195.
  87. SunYM,GeBS,KasaiM,DiffendafferC,ParksN,LiH,PengJX,LangnasA,andZhaoY.*.InductionofregulatoryTcellsfrommatureTcellsbyallogeneicthymicepithelialcellsinvitro.TransplantInternational2006,19(5):404-414.
  88. WuTH,YangRL,XieLP,WangHZ,ChenLi,ZhangSY,ZhaoY.andZhangRQ.InhibitionofcellgrowthandinductionofG1-phasecellcyclearrestinhepatomacellsbysteroidextractfromMeretix.CancerLetters2006,232(2):199-205.
  89. ZengC,WuT,ZhenY,XiaXP,ZhaoY.*.BTLA,anewinhibitoryB7familyreceptorwithaTNFRfamilyligand.Cellular&MolecularImmunology2005,2(6):427-432.
  90. ZhangJL,CaiJ,WallsS,JacksonJD,KuszynskiCA,ZhaoY.,PawliukR,LeboulchP,FoxIJ.Tolerancebyselectiveinvivoexpansionofforeignmajorhistocompatibilitycomplex-transducedautologousbonemarrow.Transplantation2005,80(3):362-369.
  91. HuangY,ErdmanN,PengH,ZhaoY.andZhengJL.TheRoleofTNFRelatedApoptosis-InducingLigandinNeurodegenerativeDiseases.Cellular&MolecularImmunology2005,2(2):113-122.
  92. SunZY,FuJY,SunLG,LiuSC,ZhaoY.andGongSL.InhibitoryEffectonTumorGrowthofTumor-AssociatedAntigenPeptidesfromMurineHepatocarcinomaH-22.U.S.ChineseJournalofLymphologyandOncology2005,4(1):11-15.
  93. SunY.M.,LiH.,LangnasA.N.andZhaoY..Alteredallogeneicimmuneresponsesinmiddle-agedmice.Cellular&MolecularImmunology2004,1(6):440-446.
  94. XiongW.F.,ZhaoY.,PrallA.K.,GreinerT.C.,andBaxter,B.T.KeyrolesofCD4+andInterferon-γinthedevelopmentofabdominalaorticaneurysmsinamurinemodel.JournalofImmunology2004,172:2607-2612.
  95. ZhaoY.*,SunY,SunY.M.,andLangnasA.N.Achievementofcellularimmunityanddiscordantxenogeneictoleranceinmicebyporcinethymusgrafts(review).Cellular&MolecularImmunology2004,1(3):173-179.
  96. SunY.M.,LangnasA.N.,andZhaoY.*.TheinteractiondefectofaccessorymoleculesisresponsibleforthepoorexvivoxenogeneicresponsetohumanantigensofmouseThelpercells.ScandinavianJournalofImmunology2003,58:59-66.
  97. SykesM.,GarrigueV.,JohsonR.P.,NikolicB.,Rodriguez-BarbosaJ.I.,RosenzweigM.,SachsD.H.,WuA.,YamadaK.,andZhaoY.*.XenogeneicthymicreplacementtoachieveimmunerestorationinHIVinfection.ClinicalandAppliedImmunologyReviews2003,3:167-171.
  98. ZhaoY.,Rodriguez-BarbosaJ.I.,ShimizuA.,SwensonK.,SachsD.H.,andSykesM.Despiteefficientintrathymicnegativeselectionofhost-reactiveTcells,autoimmunediseasemaydevelopinporcinethymus-graftedathymicmice:Evidenceforfailureofregulatorymechanismssuppressingautoimmunity.Transplantation2003,75:1832-1840.
  99. ZhaoY.,OhdanH.,ManilayJ.O.,andSykesM.NKcelltoleranceinmixedallogeneicchimeras.JournalofImmunology2003,170:5398-5405.
  100. YangT.Y.,YMSun,LangnasA.N.,andZhaoY.*.Prolongationofallogeneicskingraftsurvivalbyinjectionofanti-Ly49AmAb,YE1/48.ClinicalImmunology2003,106:148-154.
  101. ZhaoY.*,XiongW.F.,YangT.Y.,PrallA.,BaxterB.T.,andLangnasA.N.XenogeneicratskingraftrejectioninM-CSF/macrophagedeficientmice.Xenotransplantation2003,10:232-239.
  102. BeschornerW.E.,ShearonC.C.,YangT.,LangnasA.N.,ThompsonS.C.,ZhaoY.,FrancoK.L.,RadioS.J.,andSudanD.L.Pre-transplantanalysisofaccommodationindonorpigs.Xenotransplantation2003,10(1):66-71.
  103. Rodriguez-BarbosaJ.I.,ZhaoY.,HouserS.,ZhaoG.,SachsD.H.,andSykesM.Fetalporcinethymusengraftment,survivalandCD4reconstitutioninaGalKOmiceisimpairedinthepresenceofhighlevelsofantibodiesagainstaGal.Xenotransplantation2003,10(1):24-40.
  104. Rodriguez-BarbosaJ.I.,ZhaoY.,EzquerraA.,ZhaoG.,SachsD.H.,andSykesM.MurineCD4TcellsselectedinahighlydisparatexenogeneicporcinethymusgraftdonotshowrapiddecayintheabsenceofselectingMHCintheperiphery.JournalofImmunology2002,169:6697-6710.
  105. LongoG.M.,XiongW.,GreinerT.C.,ZhaoY.,FiottiN.,andBaxterB.T.Matrixmetalloproteinase2and9workinconcerttoproduceaorticaneurysms.JournalofClinicalInvestigation2002,110(5):625-632.
  106. ZhaoY.,Rodriguez-BarbosaJ.I.,ArnJ.S.,andSykesM.Highlydisparatexenogeneicskingrafttoleranceinductionbyfetalpigthymusinthymectomizedmice:Conditioningrequirementsandtheroleofcoimplantationoffetalpigliver.Transplantation2001,72:1608-1615.
  107. Rodriguez-BarbosaJ.I.,ZhaoY.,BarthR.,ZhaoG.,ArnJ.S.,SachD.H.,andSykesM.EnhancedCD4reconstitutionbygraftingneonatalporcinetissueinalternativelocationsisassociatedwithdonor-specifictoleranceandsuppressionofpre-existingxenoreactiveTcells.Transplantation2001,721223.
  108. ZhaoY.,Rodriguez-BarbosaJ.I.,ZhaoG.L.,ShafferJ.,ArnJ.S.,andSykesM.MaturationandfunctionofmouseTcellswithatransgenicTCRpositivelyselectedbyhighlydisparatexenogeneicporcineMHC.CellularandMolecularBiology2001,47:217-228.
  109. ZhaoY.,Rodriguez-BarbosaJ.I.,SwensonK.,BarthR.N.,ShimizuA.,ArnJ.S.,SachsD.H.,andSykesM.Theinductionofspecificpigskingrafttolerancebygraftingwithneonatalpigthymusinthymectomizedmice.Transplantation2000,69:1447.
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  111. AsadaA.,ZhaoY.,KomanoH.,KumataT.,FujitaK.,TozawaY.,IsekiR.,TianH.,SatoK.,MotegiY.,SuzukiR.,YokoyamaM.,andIwataM.Thecalcium-independentproteinkinaseCparticipatesinanearlyprocessofCD3/CD28-mediatedinductionofthymocyteapoptosis.CellDeathandDifferentiation.Immunology2000,101:309-315.
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  115. WekerleT.,SayeghM.H.,HillJ.,ZhaoY.,ChandrakerA.,SwensonK.G.,ZhaoG.,andSykesM.ExtrathymicTcelldeletionandallogeneicstemcellengraftmentinducedwithcostimulatoryblockadeisfollowedbycentralTcelltolerance.JournalofExperimentalMedicine1998,187:2037-2044.
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  121. ZhaoY.andIwataM.CrosslinkingoftheTcellreceptor/CD3complexandCD4,CD8,orLFA-1inducesananti-apoptoticsignalinthymocytes:thesignaliscanceledbyFK506.InternationalImmunology1995,7(9):1387-1396.
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