Sen Li
Lei-Ning Chen
Heide Schatten
Xiang-Hong Ou
Qing-Yuan Sun
aFertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China
bDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
cState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
More InformationCorresponding author: E-mail address: sunqy@gd2h.org.cn (Qing-Yuan Sun)
Publish Date:2020-11-25
Abstract
Abstract
One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged women have been proposed, including cross-over formation defect, cohesin loss, spindle deformation, spindle assembly checkpoint malfunction, microtubule-kinetochore attachment failure, kinetochore mis-orientation, mitochondria dysfunction-induced increases in reactive oxygen species, protein over-acetylation, and DNA damage. However, it still needs to be answered if these aneuploidization factors have inherent relations, and how to prevent chromosome aneuploidy in aged oocytes. Epidemiologically, oocyte aneuploidy has been found to be weakly associated with higher homocysteine concentrations, obesity, ionizing radiation and even seasonality. In this review, we summarize the research progress and present an integrated view of oocyte aneuploidization.Keywords: Aging,
Oocyte,
Aneuploidy,
Cohesin,
SAC,
Spindle,
Mitochondria,
Meiosis,
DNA damage
PDF全文下载地址:
http://www.jgenetgenomics.org/article/exportPdf?id=6b5533b5-21de-40a7-9f93-8162a0f730f6&language=en
