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The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital c

本站小编 Free考研考试/2022-01-01

Yilai Shu1, 17, 2, #,
Lijun Wang3, #,
Xiaoting Cheng4, 22, 5,
Chayada Tangshewinsirikul6, 7,
Weili Shi8, 9,
Yasheng Yuan10, 24, 11,
Zhiqiang Yan12,
Huawei Li13, 23, 14,
Jun Shen15, 16,
Bing Chen20, 21, 18,
Weiguo Zou19
1ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
2NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
3State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
4ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
5NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
6Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA
7Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
8Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
9Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, 450003, China
10ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
11NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
12State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Human Phenome Institute, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Institute of Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China
13ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
14NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
15Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA
16Harvard Medical School Center for Hereditary Deafness, Boston, MA, 02115, USA
17Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
18NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China
19State Key Laboratory of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
20ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China
21Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
22Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
23Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
24Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China

More InformationCorresponding author: E-mail address: jshen5@bwh.harvard.edu (Jun Shen);E-mail address: bingchen@fudan.edu.cn (Bing Chen);E-mail address: zouwg94@sibcb.ac.cn (Weiguo Zou)
Received Date: 2019-04-17
Accepted Date:2019-09-11
Rev Recd Date:2019-08-17
Available Online: 2019-09-27 Publish Date:2019-09-20




Abstract



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