Science China Life Sciences
Abstract
Spinal cord injury (SCI) often results in an inhibitory environment at the injury site. In our previous studies, transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI. Based on these preclinical studies, collagen scaffolds loaded with the patients’ own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients. Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years. No serious adverse events related to functional scaffold transplantation were observed. Among the patients with acute SCI, five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder. Additionally, four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction. Among patients with chronic SCI, 16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site. Nearly half of the patients with chronic cervical SCI developed enhanced finger activity. These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI.
| 论文编号: | DOI:10.1007/s11427-021-1985-5 |
| 论文题目: | Long-Term Clinical Observation of Patients with Acute and Chronic Complete Spinal Cord Injury after Transplantation of NeuroRegen Scaffold |
| 英文论文题目: | Long-Term Clinical Observation of Patients with Acute and Chronic Complete Spinal Cord Injury after Transplantation of NeuroRegen Scaffold |
| 第一作者: | Fengwu Tang, Jiaguang Tang, Yannan Zhao, Jiaojiao Zhang, Zhifeng Xiao, Bing Chen, Guang Han, Na Yin, Xianfeng Jiang, Changyu Zhao, Shixiang Cheng, Ziqiang Wang, Yumei Chen, Qiaoling Chen, Keran Song, Zhiwei Zhang, Junjie Niu, Lingjun Wang, Qin Shi, Liang Chen, Huilin Yang, Shuxun Hou, Sai Zhang & Jianwu Dai |
| 英文第一作者: | Fengwu Tang, Jiaguang Tang, Yannan Zhao, Jiaojiao Zhang, Zhifeng Xiao, Bing Chen, Guang Han, Na Yin, Xianfeng Jiang, Changyu Zhao, Shixiang Cheng, Ziqiang Wang, Yumei Chen, Qiaoling Chen, Keran Song, Zhiwei Zhang, Junjie Niu, Lingjun Wang, Qin Shi, Liang Chen, Huilin Yang, Shuxun Hou, Sai Zhang & Jianwu Dai |
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| 发表年度: | 2021-08-23 |
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| 摘要: | Spinal cord injury (SCI) often results in an inhibitory environment at the injury site. In our previous studies, transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI. Based on these preclinical studies, collagen scaffolds loaded with the patients’ own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients. Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years. No serious adverse events related to functional scaffold transplantation were observed. Among the patients with acute SCI, five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder. Additionally, four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction. Among patients with chronic SCI, 16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site. Nearly half of the patients with chronic cervical SCI developed enhanced finger activity. These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. |
| 英文摘要: | Spinal cord injury (SCI) often results in an inhibitory environment at the injury site. In our previous studies, transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI. Based on these preclinical studies, collagen scaffolds loaded with the patients’ own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients. Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years. No serious adverse events related to functional scaffold transplantation were observed. Among the patients with acute SCI, five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder. Additionally, four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction. Among patients with chronic SCI, 16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site. Nearly half of the patients with chronic cervical SCI developed enhanced finger activity. These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. |
| 刊物名称: | Science China Life Sciences |
| 英文刊物名称: | Science China Life Sciences |
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| 其它备注: | Fengwu Tang, Jiaguang Tang, Yannan Zhao, Jiaojiao Zhang, Zhifeng Xiao, Bing Chen, Guang Han, Na Yin, Xianfeng Jiang, Changyu Zhao, Shixiang Cheng, Ziqiang Wang, Yumei Chen, Qiaoling Chen, Keran Song, Zhiwei Zhang, Junjie Niu, Lingjun Wang, Qin Shi, Liang Chen, Huilin Yang, Shuxun Hou, Sai Zhang & Jianwu Dai. Long-Term Clinical Observation of Patients with Acute and Chronic Complete Spinal Cord Injury after Transplantation of NeuroRegen Scaffold. Science China Life Sciences. DOI:10.1007/s11427-021-1985-5 |
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