Science
Abstract
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
| 论文编号: | DOI:10.1126/science.abe5017 |
| 论文题目: | Daily Energy Expenditure Through the Human Life Course |
| 英文论文题目: | Daily Energy Expenditure Through the Human Life Course |
| 第一作者: | Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama,…Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, IAEA DLW Database Consortium |
| 英文第一作者: | Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama,…Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, IAEA DLW Database Consortium |
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| 发表年度: | 2021-08-13 |
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| 摘要: | Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span. |
| 英文摘要: | Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span. |
| 刊物名称: | Science |
| 英文刊物名称: | Science |
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| 其它备注: | Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama,…Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman, IAEA DLW Database ConsortiumDaily Energy Expenditure Through the Human Life Course. Science. DOI:10.1126/science.abe5017 |
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