Journal of Cell Biology
Abstract
Induction of long-term potentiation (LTP) in excitatory neurons triggers a large transient increase in the volume of dendritic spines followed by decays to sustained size expansion, a process termed structural LTP (sLTP) that contributes to the cellular basis of learning and memory. Although mechanisms regulating the early and sustained phases of sLTP have been studied intensively, how the acute spine enlargement immediately after LTP stimulation is achieved remains elusive. Here, we report that endophilin A1 orchestrates membrane dynamics with actin polymerization to initiate spine enlargement in NMDAR-mediated LTP. Upon LTP induction, Ca2+/calmodulin enhances binding of endophilin A1 to both membrane and p140Cap, a cytoskeletal regulator. Consequently, endophilin A1 rapidly localizes to the plasma membrane and recruits p140Cap to promote local actin polymerization, leading to spine head expansion. Moreover, its molecular functions in activity-induced rapid spine growth are required for LTP and long-term memory. Thus, endophilin A1 serves as a calmodulin effector to drive acute structural plasticity necessary for learning and memory.
| 论文编号: | DOI:10.1083/jcb.202007172 |
| 论文题目: | Endophilin A1 Drives Acute Structural Plasticity of Dendritic Spines in Response to Ca2+/Calmodulin |
| 英文论文题目: | Endophilin A1 Drives Acute Structural Plasticity of Dendritic Spines in Response to Ca2+/Calmodulin |
| 第一作者: | Yanrui Yang, Jiang Chen, Xue Chen, Di Li, Jianfeng He, Shen Wang, Shun Zhao, Xiaoyu Yang, Shikun Deng, Chunfang Tong, Dou Wang, Zhenzhen Guo, Dong Li, Cong Ma, Xin Liang, Yun S. Shi, Jia-Jia Liu |
| 英文第一作者: | Yanrui Yang, Jiang Chen, Xue Chen, Di Li, Jianfeng He, Shen Wang, Shun Zhao, Xiaoyu Yang, Shikun Deng, Chunfang Tong, Dou Wang, Zhenzhen Guo, Dong Li, Cong Ma, Xin Liang, Yun S. Shi, Jia-Jia Liu |
| 联系作者: | |
| 英文联系作者: | |
| 外单位作者单位: | |
| 英文外单位作者单位: | |
| 发表年度: | 2021-05-17 |
| 卷: | |
| 期: | |
| 页码: | |
| 摘要: | Induction of long-term potentiation (LTP) in excitatory neurons triggers a large transient increase in the volume of dendritic spines followed by decays to sustained size expansion, a process termed structural LTP (sLTP) that contributes to the cellular basis of learning and memory. Although mechanisms regulating the early and sustained phases of sLTP have been studied intensively, how the acute spine enlargement immediately after LTP stimulation is achieved remains elusive. Here, we report that endophilin A1 orchestrates membrane dynamics with actin polymerization to initiate spine enlargement in NMDAR-mediated LTP. Upon LTP induction, Ca2+/calmodulin enhances binding of endophilin A1 to both membrane and p140Cap, a cytoskeletal regulator. Consequently, endophilin A1 rapidly localizes to the plasma membrane and recruits p140Cap to promote local actin polymerization, leading to spine head expansion. Moreover, its molecular functions in activity-induced rapid spine growth are required for LTP and long-term memory. Thus, endophilin A1 serves as a calmodulin effector to drive acute structural plasticity necessary for learning and memory. |
| 英文摘要: | Induction of long-term potentiation (LTP) in excitatory neurons triggers a large transient increase in the volume of dendritic spines followed by decays to sustained size expansion, a process termed structural LTP (sLTP) that contributes to the cellular basis of learning and memory. Although mechanisms regulating the early and sustained phases of sLTP have been studied intensively, how the acute spine enlargement immediately after LTP stimulation is achieved remains elusive. Here, we report that endophilin A1 orchestrates membrane dynamics with actin polymerization to initiate spine enlargement in NMDAR-mediated LTP. Upon LTP induction, Ca2+/calmodulin enhances binding of endophilin A1 to both membrane and p140Cap, a cytoskeletal regulator. Consequently, endophilin A1 rapidly localizes to the plasma membrane and recruits p140Cap to promote local actin polymerization, leading to spine head expansion. Moreover, its molecular functions in activity-induced rapid spine growth are required for LTP and long-term memory. Thus, endophilin A1 serves as a calmodulin effector to drive acute structural plasticity necessary for learning and memory. |
| 刊物名称: | Journal of Cell Biology |
| 英文刊物名称: | Journal of Cell Biology |
| 论文全文: | |
| 英文论文全文: | |
| 全文链接: | |
| 其它备注: | Yanrui Yang, Jiang Chen, Xue Chen, Di Li, Jianfeng He, Shen Wang, Shun Zhao, Xiaoyu Yang, Shikun Deng, Chunfang Tong, Dou Wang, Zhenzhen Guo, Dong Li, Cong Ma, Xin Liang, Yun S. Shi, Jia-Jia Liu. Endophilin A1 Drives Acute Structural Plasticity of Dendritic Spines in Response to Ca2+/Calmodulin. Journal of Cell Biology. DOI:10.1083/jcb.202007172 |
| 英文其它备注: | |
| 学科: | |
| 英文学科: | |
| 影响因子: | |
| 第一作者所在部门: | |
| 英文第一作者所在部门: | |
| 论文出处: | |
| 英文论文出处: | |
| 论文类别: | |
| 英文论文类别: | |
| 参与作者: | |
| 英文参与作者: |
