Stem Cells
Abstract
Spinal cord injury (SCI) typically results in long‐lasting functional deficits, largely due to primary and secondary white matter damage at the site of injury. The transplantation of neural stem cells (NSCs) has shown promise for re‐establishing communications between separated regions of the spinal cord through the insertion of new neurons between the injured axons and target neurons. However, the inhibitory microenvironment that develops after SCI often causes endogenous and transplanted NSCs to differentiate into glial cells rather than neurons. Functional biomaterials have been shown to mitigate the effects of the adverse SCI microenvironment and promote the neuronal differentiation of NSCs. A clear understanding of the mechanisms of neuronal differentiation within the injury‐induced microenvironment would likely allow for the development of treatment strategies designed to promote the innate ability of NSCs to differentiate into neurons. The increased differentiation of neurons may contribute to relay formation, facilitating functional recovery after SCI. In this review, we summarize current strategies used to enhance the neuronal differentiation of NSCs through the reconstruction of the SCI microenvironment and to improve the intrinsic neuronal differentiation abilities of NSCs, which is significant for SCI repair.
| 论文编号: | DOI:10.1002/stem.3366 |
| 论文题目: | Direct Neuronal Differentiation of Neural Stem Cells for Spinal Cord Injury Repair |
| 英文论文题目: | Direct Neuronal Differentiation of Neural Stem Cells for Spinal Cord Injury Repair |
| 第一作者: | Weiwei Xue, Caixia Fan, Bing Chen, Yannan Zhao, Zhifeng Xiao, Jianwu Dai |
| 英文第一作者: | Weiwei Xue, Caixia Fan, Bing Chen, Yannan Zhao, Zhifeng Xiao, Jianwu Dai |
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| 发表年度: | 2021-03-16 |
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| 摘要: | Spinal cord injury (SCI) typically results in long‐lasting functional deficits, largely due to primary and secondary white matter damage at the site of injury. The transplantation of neural stem cells (NSCs) has shown promise for re‐establishing communications between separated regions of the spinal cord through the insertion of new neurons between the injured axons and target neurons. However, the inhibitory microenvironment that develops after SCI often causes endogenous and transplanted NSCs to differentiate into glial cells rather than neurons. Functional biomaterials have been shown to mitigate the effects of the adverse SCI microenvironment and promote the neuronal differentiation of NSCs. A clear understanding of the mechanisms of neuronal differentiation within the injury‐induced microenvironment would likely allow for the development of treatment strategies designed to promote the innate ability of NSCs to differentiate into neurons. The increased differentiation of neurons may contribute to relay formation, facilitating functional recovery after SCI. In this review, we summarize current strategies used to enhance the neuronal differentiation of NSCs through the reconstruction of the SCI microenvironment and to improve the intrinsic neuronal differentiation abilities of NSCs, which is significant for SCI repair. |
| 英文摘要: | Spinal cord injury (SCI) typically results in long‐lasting functional deficits, largely due to primary and secondary white matter damage at the site of injury. The transplantation of neural stem cells (NSCs) has shown promise for re‐establishing communications between separated regions of the spinal cord through the insertion of new neurons between the injured axons and target neurons. However, the inhibitory microenvironment that develops after SCI often causes endogenous and transplanted NSCs to differentiate into glial cells rather than neurons. Functional biomaterials have been shown to mitigate the effects of the adverse SCI microenvironment and promote the neuronal differentiation of NSCs. A clear understanding of the mechanisms of neuronal differentiation within the injury‐induced microenvironment would likely allow for the development of treatment strategies designed to promote the innate ability of NSCs to differentiate into neurons. The increased differentiation of neurons may contribute to relay formation, facilitating functional recovery after SCI. In this review, we summarize current strategies used to enhance the neuronal differentiation of NSCs through the reconstruction of the SCI microenvironment and to improve the intrinsic neuronal differentiation abilities of NSCs, which is significant for SCI repair. |
| 刊物名称: | Stem Cells |
| 英文刊物名称: | Stem Cells |
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| 其它备注: | Weiwei Xue, Caixia Fan, Bing Chen, Yannan Zhao, Zhifeng Xiao, Jianwu Dai. Direct Neuronal Differentiation of Neural Stem Cells for Spinal Cord Injury Repair. Stem Cells. DOI:10.1002/stem.3366 |
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