Current Biology
Abstract
In plants and animals, self-renewing stem cell populations play fundamental roles in many developmental contexts. Plants differ from most animals in their retained ability to initiate new cycles of growth and development, which relies on the establishment and activity of branch meristems. In seed plants, branching is achieved by stem-cell-containing axillary meristems, which are initiated from a leaf axil meristematic cell population originally detached from the shoot apicalmeristem. It remains unclear how the meristematic cell fate is maintained. Here, we show thatARABIDOPSISTHALIANAHOMEOBOXGENE1(ATH1) maintains the meristem marker geneSHOOT MERISTEMLESS(STM) expression in the leaf axil toenable meristematic cell fate maintenance. Furthermore, ATH1 protein interacts with STM protein to form aSTMself-activation loop. Genetic and biochemical data suggest that ATH1 anchors STM to activateSTMas well as other axillary meristem regulatory genes. This auto-regulation allows theSTMlocus to remain epigenetically active. Taken together, our findings provide a striking example of a self-activation loop that maintains the flexibility required for stem cell niche re-establishment during organogenesis.
| 论文编号: | DOI:10.1016/j.cub.2020.03.031 |
| 论文题目: | A Self-Activation Loop Maintains Meristematic Cell Fate for Branching |
| 英文论文题目: | A Self-Activation Loop Maintains Meristematic Cell Fate for Branching |
| 第一作者: | Xiuwei Cao, Jin Wang, Yuanyuan Xiong, Haibian Yang, Minglei Yang, Peiyi Ye, Stefano Bencivenga, Robert Sablowski, Yuling Jiao |
| 英文第一作者: | Xiuwei Cao, Jin Wang, Yuanyuan Xiong, Haibian Yang, Minglei Yang, Peiyi Ye, Stefano Bencivenga, Robert Sablowski, Yuling Jiao |
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| 发表年度: | 2020-04-03 |
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| 摘要: | In plants and animals, self-renewing stem cell populations play fundamental roles in many developmental contexts. Plants differ from most animals in their retained ability to initiate new cycles of growth and development, which relies on the establishment and activity of branch meristems. In seed plants, branching is achieved by stem-cell-containing axillary meristems, which are initiated from a leaf axil meristematic cell population originally detached from the shoot apicalmeristem. It remains unclear how the meristematic cell fate is maintained. Here, we show thatARABIDOPSISTHALIANAHOMEOBOXGENE1(ATH1) maintains the meristem marker geneSHOOT MERISTEMLESS(STM) expression in the leaf axil toenable meristematic cell fate maintenance. Furthermore, ATH1 protein interacts with STM protein to form aSTMself-activation loop. Genetic and biochemical data suggest that ATH1 anchors STM to activateSTMas well as other axillary meristem regulatory genes. This auto-regulation allows theSTMlocus to remain epigenetically active. Taken together, our findings provide a striking example of a self-activation loop that maintains the flexibility required for stem cell niche re-establishment during organogenesis. |
| 英文摘要: | In plants and animals, self-renewing stem cell populations play fundamental roles in many developmental contexts. Plants differ from most animals in their retained ability to initiate new cycles of growth and development, which relies on the establishment and activity of branch meristems. In seed plants, branching is achieved by stem-cell-containing axillary meristems, which are initiated from a leaf axil meristematic cell population originally detached from the shoot apicalmeristem. It remains unclear how the meristematic cell fate is maintained. Here, we show thatARABIDOPSISTHALIANAHOMEOBOXGENE1(ATH1) maintains the meristem marker geneSHOOT MERISTEMLESS(STM) expression in the leaf axil toenable meristematic cell fate maintenance. Furthermore, ATH1 protein interacts with STM protein to form aSTMself-activation loop. Genetic and biochemical data suggest that ATH1 anchors STM to activateSTMas well as other axillary meristem regulatory genes. This auto-regulation allows theSTMlocus to remain epigenetically active. Taken together, our findings provide a striking example of a self-activation loop that maintains the flexibility required for stem cell niche re-establishment during organogenesis. |
| 刊物名称: | Current Biology |
| 英文刊物名称: | Current Biology |
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| 其它备注: | Xiuwei Cao, Jin Wang, Yuanyuan Xiong, Haibian Yang, Minglei Yang, Peiyi Ye, Stefano Bencivenga, Robert Sablowski, Yuling Jiao. A Self-Activation Loop Maintains Meristematic Cell Fate for Branching. Current Biology. DOI:10.1016/j.cub.2020.03.031 |
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