Cell Research
Abstract
Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation.
| 论文编号: | DOI:10.1038/s41422-019-0145-8 |
| 论文题目: | An H3K27me3 Demethylase-HSFA2 Regulatory Loop Orchestrates Transgenerational Thermomemory in Arabidopsis |
| 英文论文题目: | An H3K27me3 Demethylase-HSFA2 Regulatory Loop Orchestrates Transgenerational Thermomemory in Arabidopsis |
| 第一作者: | Junzhong Liu, Lili Feng, Xueting Gu, Xian Deng, Qi Qiu, Qun Li, Yingying Zhang, Muyang Wang, Yiwen Deng, Ertao Wang, Yuke He, Isabel Baurle, Jianming Li, Xiaofeng Cao, Zuhua He |
| 英文第一作者: | Junzhong Liu, Lili Feng, Xueting Gu, Xian Deng, Qi Qiu, Qun Li, Yingying Zhang, Muyang Wang, Yiwen Deng, Ertao Wang, Yuke He, Isabel Baurle, Jianming Li, Xiaofeng Cao, Zuhua He |
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| 发表年度: | 2019-02-21 |
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| 摘要: | Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation. |
| 英文摘要: | Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation. |
| 刊物名称: | Cell Research |
| 英文刊物名称: | Cell Research |
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| 其它备注: | Junzhong Liu, Lili Feng, Xueting Gu, Xian Deng, Qi Qiu, Qun Li, Yingying Zhang, Muyang Wang, Yiwen Deng, Ertao Wang, Yuke He, Isabel Baurle, Jianming Li, Xiaofeng Cao, Zuhua He. An H3K27me3 Demethylase-HSFA2 Regulatory Loop Orchestrates Transgenerational Thermomemory in Arabidopsis. Cell Research. DOI:10.1038/s41422-019-0145-8 |
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