Neuron
Abstract
In the neurogenic niches, adult neural stem and/orprogenitor cells(NSCs) generate functional neurons throughout life, which has been implicated in learning and memory and affective behaviors. Duringadult neurogenesis, newborn neurons release feedback signals into the niches to regulate NSC proliferation and differentiation. However, whether and howNSCscontribute to the niche governing newborn neuron development is still unknown. Using a combination of cell ablation, retrovirus-mediated single-cell labeling, and signaling pathway modulation, we show that adulthippocampalNSCs continuously supplypleiotrophinfactor to the newborn neurons. Without this feedforward signal, the newborn neurons display defective dendritic development and arborization. Thus, our findings reveal that NSCs behave as a functional niche for newly generated newborn neurons to regulate their maturation.
| 论文编号: | DOI:10.1016/j.neuron.2018.10.051 |
| 论文题目: | Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN |
| 英文论文题目: | Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN |
| 第一作者: | Changyong Tang, Min Wang, Peijian Wang, Lei Wang, Qingfeng Wu, Weixiang Guo |
| 英文第一作者: | Changyong Tang, Min Wang, Peijian Wang, Lei Wang, Qingfeng Wu, Weixiang Guo |
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| 发表年度: | 2018-11-27 |
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| 摘要: | In the neurogenic niches, adult neural stem and/orprogenitor cells(NSCs) generate functional neurons throughout life, which has been implicated in learning and memory and affective behaviors. Duringadult neurogenesis, newborn neurons release feedback signals into the niches to regulate NSC proliferation and differentiation. However, whether and howNSCscontribute to the niche governing newborn neuron development is still unknown. Using a combination of cell ablation, retrovirus-mediated single-cell labeling, and signaling pathway modulation, we show that adulthippocampalNSCs continuously supplypleiotrophinfactor to the newborn neurons. Without this feedforward signal, the newborn neurons display defective dendritic development and arborization. Thus, our findings reveal that NSCs behave as a functional niche for newly generated newborn neurons to regulate their maturation. |
| 英文摘要: | In the neurogenic niches, adult neural stem and/orprogenitor cells(NSCs) generate functional neurons throughout life, which has been implicated in learning and memory and affective behaviors. Duringadult neurogenesis, newborn neurons release feedback signals into the niches to regulate NSC proliferation and differentiation. However, whether and howNSCscontribute to the niche governing newborn neuron development is still unknown. Using a combination of cell ablation, retrovirus-mediated single-cell labeling, and signaling pathway modulation, we show that adulthippocampalNSCs continuously supplypleiotrophinfactor to the newborn neurons. Without this feedforward signal, the newborn neurons display defective dendritic development and arborization. Thus, our findings reveal that NSCs behave as a functional niche for newly generated newborn neurons to regulate their maturation. |
| 刊物名称: | Neuron |
| 英文刊物名称: | Neuron |
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| 其它备注: | Changyong Tang, Min Wang, Peijian Wang, Lei Wang, Qingfeng Wu, Weixiang Guo. Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. DOI:10.1016/j.neuron.2018.10.051 |
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