Nucleic Acids Research
Abstract
Traditional Chinese medicine (TCM) is not only an effective solution for primary health care, but also a great resource for drug innovation and discovery. To meet the increasing needs for TCM-related data resources, we developed ETCM, an Encyclopedia of Traditional Chinese Medicine. ETCM includes comprehensive and standardized information for the commonly used herbs and formulas of TCM, as well as their ingredients. The herb basic property and quality control standard, formula composition, ingredient drug-likeness, as well as many other information provided by ETCM can serve as a convenient resource for users to obtain thorough information about a herb or a formula. To facilitate functional and mechanistic studies of TCM, ETCM provides predicted target genes of TCM ingredients, herbs, and formulas, according to the chemical fingerprint similarity between TCM ingredients and known drugs. A systematic analysis function is also developed in ETCM, which allows users to explore the relationships or build networks among TCM herbs, formulas, ingredients, gene targets, and related pathways or diseases. ETCM is freely accessible at http://www.nrc.ac.cn:9090/ETCM/. We expect ETCM to develop into a major data warehouse for TCM and to promote TCM related researches and drug development in the future.
| 论文编号: | DOI:10.1093/nar/gky987 |
| 论文题目: | ETCM: an Encyclopaedia of Traditional Chinese Medicine |
| 英文论文题目: | ETCM: an Encyclopaedia of Traditional Chinese Medicine |
| 第一作者: | Hai-Yu Xu, Yan-Qiong Zhang, Zhen-Ming Liu, Tong Chen, Chuan-Yu Lv, Shi-Huan Tang, Xiao-Bo Zhang, Wei Zhang, Zhi-Yong Li, Rong-Rong Zhou, Hong-Jun Yang, Xiu-Jie Wang and Lu-Qi Huang |
| 英文第一作者: | Hai-Yu Xu, Yan-Qiong Zhang, Zhen-Ming Liu, Tong Chen, Chuan-Yu Lv, Shi-Huan Tang, Xiao-Bo Zhang, Wei Zhang, Zhi-Yong Li, Rong-Rong Zhou, Hong-Jun Yang, Xiu-Jie Wang and Lu-Qi Huang |
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| 英文外单位作者单位: | Nucleic Acids Research |
| 发表年度: | 2018-11-12 |
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| 摘要: | Traditional Chinese medicine (TCM) is not only an effective solution for primary health care, but also a great resource for drug innovation and discovery. To meet the increasing needs for TCM-related data resources, we developed ETCM, an Encyclopedia of Traditional Chinese Medicine. ETCM includes comprehensive and standardized information for the commonly used herbs and formulas of TCM, as well as their ingredients. The herb basic property and quality control standard, formula composition, ingredient drug-likeness, as well as many other information provided by ETCM can serve as a convenient resource for users to obtain thorough information about a herb or a formula. To facilitate functional and mechanistic studies of TCM, ETCM provides predicted target genes of TCM ingredients, herbs, and formulas, according to the chemical fingerprint similarity between TCM ingredients and known drugs. A systematic analysis function is also developed in ETCM, which allows users to explore the relationships or build networks among TCM herbs, formulas, ingredients, gene targets, and related pathways or diseases. ETCM is freely accessible at http://www.nrc.ac.cn:9090/ETCM/. We expect ETCM to develop into a major data warehouse for TCM and to promote TCM related researches and drug development in the future. |
| 英文摘要: | Traditional Chinese medicine (TCM) is not only an effective solution for primary health care, but also a great resource for drug innovation and discovery. To meet the increasing needs for TCM-related data resources, we developed ETCM, an Encyclopedia of Traditional Chinese Medicine. ETCM includes comprehensive and standardized information for the commonly used herbs and formulas of TCM, as well as their ingredients. The herb basic property and quality control standard, formula composition, ingredient drug-likeness, as well as many other information provided by ETCM can serve as a convenient resource for users to obtain thorough information about a herb or a formula. To facilitate functional and mechanistic studies of TCM, ETCM provides predicted target genes of TCM ingredients, herbs, and formulas, according to the chemical fingerprint similarity between TCM ingredients and known drugs. A systematic analysis function is also developed in ETCM, which allows users to explore the relationships or build networks among TCM herbs, formulas, ingredients, gene targets, and related pathways or diseases. ETCM is freely accessible at http://www.nrc.ac.cn:9090/ETCM/. We expect ETCM to develop into a major data warehouse for TCM and to promote TCM related researches and drug development in the future. |
| 刊物名称: | Nucleic Acids Research |
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| 其它备注: | Hai-Yu Xu, Yan-Qiong Zhang, Zhen-Ming Liu, Tong Chen, Chuan-Yu Lv, Shi-Huan Tang, Xiao-Bo Zhang, Wei Zhang, Zhi-Yong Li, Rong-Rong Zhou, Hong-Jun Yang, Xiu-Jie Wang and Lu-Qi Huang. ETCM: an Encyclopaedia of Traditional Chinese Medicine. Nucleic Acids Research. DOI:10.1093/nar/gky987 |
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