Cell Research
Abstract
The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through promoting the translation of neuronal early-response genes. Such effect is exquisitely dependent on the m6A methyltransferase function of METTL3. Depleting METTL3 in mouse hippocampus reduced memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m6A methyltransferase function of METTL3 was restored. The abundance of METTL3 in wild-type mouse hippocampus is positively correlated with learning efficacy, and overexpression of METTL3 significantly enhances long-term memory consolidation. These findings uncover a direct role of RNA m6A modification in regulating long-term memory formation, and also indicate that memory efficacy difference among individuals could be compensated by repeated learning.
| 论文编号: | DOI:10.1038/s41422-018-0092-9 |
| 论文题目: | METTL3-mediated N6-methyladenosine mRNA Modification Enhances Long-term Memory Consolidation |
| 英文论文题目: | METTL3-mediated N6-methyladenosine mRNA Modification Enhances Long-term Memory Consolidation |
| 第一作者: | Zeyu Zhang, Meng Wang, Dongfang Xie, Zenghui Huang, Lisha Zhang, Ying Yang, Dongxue Ma, Wenguang Li, Qi Zhou, Yun-Gui Yang, and Xiu-Jie Wang |
| 英文第一作者: | Zeyu Zhang, Meng Wang, Dongfang Xie, Zenghui Huang, Lisha Zhang, Ying Yang, Dongxue Ma, Wenguang Li, Qi Zhou, Yun-Gui Yang, and Xiu-Jie Wang |
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| 发表年度: | 2018-10-10 |
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| 摘要: | The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through promoting the translation of neuronal early-response genes. Such effect is exquisitely dependent on the m6A methyltransferase function of METTL3. Depleting METTL3 in mouse hippocampus reduced memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m6A methyltransferase function of METTL3 was restored. The abundance of METTL3 in wild-type mouse hippocampus is positively correlated with learning efficacy, and overexpression of METTL3 significantly enhances long-term memory consolidation. These findings uncover a direct role of RNA m6A modification in regulating long-term memory formation, and also indicate that memory efficacy difference among individuals could be compensated by repeated learning. |
| 英文摘要: | The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through promoting the translation of neuronal early-response genes. Such effect is exquisitely dependent on the m6A methyltransferase function of METTL3. Depleting METTL3 in mouse hippocampus reduced memory consolidation ability, yet unimpaired learning outcomes can be achieved if adequate training was given or the m6A methyltransferase function of METTL3 was restored. The abundance of METTL3 in wild-type mouse hippocampus is positively correlated with learning efficacy, and overexpression of METTL3 significantly enhances long-term memory consolidation. These findings uncover a direct role of RNA m6A modification in regulating long-term memory formation, and also indicate that memory efficacy difference among individuals could be compensated by repeated learning. |
| 刊物名称: | Cell Research |
| 英文刊物名称: | Cell Research |
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| 其它备注: | Zeyu Zhang, Meng Wang, Dongfang Xie, Zenghui Huang, Lisha Zhang, Ying Yang, Dongxue Ma, Wenguang Li, Qi Zhou, Yun-Gui Yang, and Xiu-Jie Wang. METTL3-mediated N6-methyladenosine mRNA Modification Enhances Long-term Memory Consolidation. Cell Research. DOI:10.1038/s41422-018-0092-9 |
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