Nature Communications
Abstract
Sugars function as signal molecules to regulate growth, development, and gene expression in plants, yeasts, and animals. A coordination of sugar availability with phytohormone signals is crucial for plant growth and development. The molecular link between sugar availability and hormone-dependent plant growth are largely unknown. Here we report that BRI1 and BAK1 are involved in sugar-responsive growth and development. Glucose influences the physical interactions and phosphorylations of BRI1 and BAK1 in a concentration-dependent manner. BRI1 and BAK1 physically interact with G proteins that are essential for mediating sugar signaling. Biochemical data show that BRI1 can phosphorylate G protein β subunit and γ subunits, and BAK1 can phosphorylate G protein γ subunits. Genetic analyses suggest that BRI1 and BAK1 function in a common pathway with G-protein subunits to regulate sugar responses. Thus, our findings reveal an important genetic and molecular mechanism by which BR receptors associate with G proteins to regulate sugar-responsive growth and development.
| 论文编号: | DOI:10.1038/s41467-018-03884-8 |
| 论文题目: | BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis |
| 英文论文题目: | BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis |
| 第一作者: | Yuancheng Peng, Liangliang Chen, Shengjun Li, Yueying Zhang, Ran Xu, Zupei Liu, Wuxia Liu, Jingjing Kong, Xiahe Huang, Yingchun Wang, Beijiu Cheng, Leiying Zheng & Yunhai Li |
| 英文第一作者: | Yuancheng Peng, Liangliang Chen, Shengjun Li, Yueying Zhang, Ran Xu, Zupei Liu, Wuxia Liu, Jingjing Kong, Xiahe Huang, Yingchun Wang, Beijiu Cheng, Leiying Zheng & Yunhai Li |
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| 发表年度: | 2018-04-19 |
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| 摘要: | Sugars function as signal molecules to regulate growth, development, and gene expression in plants, yeasts, and animals. A coordination of sugar availability with phytohormone signals is crucial for plant growth and development. The molecular link between sugar availability and hormone-dependent plant growth are largely unknown. Here we report that BRI1 and BAK1 are involved in sugar-responsive growth and development. Glucose influences the physical interactions and phosphorylations of BRI1 and BAK1 in a concentration-dependent manner. BRI1 and BAK1 physically interact with G proteins that are essential for mediating sugar signaling. Biochemical data show that BRI1 can phosphorylate G protein β subunit and γ subunits, and BAK1 can phosphorylate G protein γ subunits. Genetic analyses suggest that BRI1 and BAK1 function in a common pathway with G-protein subunits to regulate sugar responses. Thus, our findings reveal an important genetic and molecular mechanism by which BR receptors associate with G proteins to regulate sugar-responsive growth and development. |
| 英文摘要: | Sugars function as signal molecules to regulate growth, development, and gene expression in plants, yeasts, and animals. A coordination of sugar availability with phytohormone signals is crucial for plant growth and development. The molecular link between sugar availability and hormone-dependent plant growth are largely unknown. Here we report that BRI1 and BAK1 are involved in sugar-responsive growth and development. Glucose influences the physical interactions and phosphorylations of BRI1 and BAK1 in a concentration-dependent manner. BRI1 and BAK1 physically interact with G proteins that are essential for mediating sugar signaling. Biochemical data show that BRI1 can phosphorylate G protein β subunit and γ subunits, and BAK1 can phosphorylate G protein γ subunits. Genetic analyses suggest that BRI1 and BAK1 function in a common pathway with G-protein subunits to regulate sugar responses. Thus, our findings reveal an important genetic and molecular mechanism by which BR receptors associate with G proteins to regulate sugar-responsive growth and development. |
| 刊物名称: | Nature Communications |
| 英文刊物名称: | Nature Communications |
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| 其它备注: | Yuancheng Peng, Liangliang Chen, Shengjun Li, Yueying Zhang, Ran Xu, Zupei Liu, Wuxia Liu, Jingjing Kong, Xiahe Huang, Yingchun Wang, Beijiu Cheng, Leiying Zheng & Yunhai Li. BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis. Nature Communications. DOI:10.1038/s41467-018-03884-8 |
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