中文关键词:酰腙 阿魏酸 抗病毒活性 烟草花叶病毒 英文关键词:Acylhydrazone, Ferulic acid, Antiviral activity, TMV 基金项目:国家自然科学基金重点项目(21132003)和特色稻种资源收集、保存与创制利用项目(黔农科院种质资源[2020]11)资助

作者	单位	E-mail
王珍珍	贵州省水稻研究所	1510759448@qq.com
王晓斌	江苏省农药学重点实验室 南京农业大学 南京

摘要点击次数:150 全文下载次数:0 中文摘要: 将酰腙结构引入到阿魏酸衍生物中,合成了6个阿魏酸酰腙类化合物,其结构经过了IR、1H NMR、13C NMR和ESI-HRMS表征。抗病毒活性测试结果表明,在质量浓度为500 mg/L时,化合物3、5和6对烟草花叶病毒(TMV)在保护、治疗和钝化活性方面的抑制率均优于对照药剂病毒唑。进一步的EC50测试结果表明,化合物3、5和6钝化活性的EC50值分别为91.25、54.86、58.22 mg/L,明显低于病毒唑的EC50值(126.05 mg/L)。该研究结果表明,阿魏酸酰腙类化合物对TMV具有较好的抗病毒活性,对其进行适当的结构改进和优化,有望得到具有更高抗病毒活性的化合物。 英文摘要: Six compounds were synthesized by introducing acylhydrazone unit into ferulic acid derivatives, and their structures were characterized by IR,1H NMR, 13C NMR and ESI-HRMS. Antiviral activity test results showed that compounds 3, 5, and 6 presented good protective, curative and inactivating activity against TMV, which were superior to the control drug ribavirin at 500 mg/L. The EC50 values of the inactivation activity of compounds 3, 5 and 6 on TMV were 91.25, 54.86, and 58.22 mg/L, which were significantly lower than the EC50 value (126.05 mg/L) of ribavirin. The results indicated that ferulic acid derivatives containing acylhydrazone moiety had potent antiviral activity against TMV. It is expected that compounds with higher antiviral activity can be obtained after proper structural improvement and optimization. 查看全文查看/发表评论下载PDF阅读器 相关附件：附件1附件2版权转让声明书修改说明 -->