中文关键词:α-氨基腈 Strecker反应 新型氰化物 英文关键词:α-aminonitriles, the Strecker reaction, novel cyanides 基金项目:国家自然科学基金项目（21576229）

作者	单位	E-mail
尹科	湘潭大学化工学院	1097631504@qq.com
段正康	湘潭大学化工学院
张蕾	湘潭大学化工学院
朱宏文	湘潭大学化工学院

摘要点击次数:2095 全文下载次数:0 中文摘要: α-氨基腈是合成多种氨基酸的重要中间体，广泛的应用于化学、生物、医药等领域。Strecker反应作为最重要的合成α-氨基腈的方法，具有简单高效、底物范围广、可合成手性α-氨基腈等特点，一直受到研究者们极大的关注。传统Strecker反应以剧毒HCN为氰源，危险性大，操作条件苛刻，严重限制了该反应的发展。本文综述了近年来新型氰化物在Strecker反应合成α-氨基腈中的研究进展，重点阐述了以三甲基硅氰(TMSCN)为氰源的Strecker反应的催化剂开发、反应机理和反应条件优化情况，并展望了Strecker反应合成α-氨基腈的研究方向和发展前景。 英文摘要: α-aminonitriles are significantly important intermediates for the synthesis of numerous amino acids. At present, α-aminonitriles have been widely used in chemical, biological, medicine and other fields. Strecker reaction as one of the most important method of synthesis of α-aminonitriles, with such advantages, simple and efficient, widely range of substrates, and could synthesize chiral α-aminonitriles etc, has been attracting the great attention of the researchers. The greatest limitation of Strecker reaction is used highly toxic HCN, which is harmful to human body and environment. In this paper, the recent advance of alternative cyanide sources in the Strecker reaction has been reviewed, the development of catalysts, and optimization of reaction conditions of the reaction which used trimethylsilyl cyanide(TMSCN) as cyanide sources has been specially expounded, and the research direction of Strecker reaction also has been prospected. 查看全文查看/发表评论下载PDF阅读器 相关附件：版权转让声明书 -->