中文关键词:Suzuki 反应无配体 低温反应联苯化合物 三联苯 英文关键词:Suzukireaction, Ligand-free, Low temperature, Biaryl compounds, Terphenyls 基金项目:国家自然科学基金项目（81660575, 81360471)、贵州省科技厅基础研究项目 [2018]1187.

作者	单位	E-mail
李新民	遵义医学院 药学院	lixinmin19@126.com
冯芳芳	遵义医学院 药学院
胡庆红	遵义医学院 药学院
吴庆	遵义医学院 药学院
袁泽利	遵义医学院 药学院

摘要点击次数:1766 全文下载次数:0 中文摘要: 发展了一个低温下无配体钯催化溴代芳烃与芳基硼酸的Suzuki反应体系。该体系以醋酸钯为催化剂,无水碳酸钾为碱,乙醇水溶液为溶剂,无需加入任何配体,在0 _oC下即可高效催化溴代芳烃与芳基硼酸的Suzuki反应,底物容忍性好,产品分离收率最高达97%；以溴代芳基N-甲基亚氨基二乙酸硼酸酯为砌块分子,通过调控反应温度,实现了砌块分子选择性Suzuki反应,从而一锅合成了不对称三联苯化合物,产品收率最高为81%。 英文摘要: The development of a palladium-catalyzed ligand-free Suzuki reaction system of aryl bromides and arylboronic acids at low temperature. Using Pd(OAc)₂ as catalyst, K₂CO₃ as base and aqueous ethanol as solvent, various aryl bromides could couple with arylboronic acids efficiently with the highest product yield up to 97%. Using bromo-phenyl N-methyliminodiacetic acid boronate as building block, the chemoselective Suzuki reactions were proceeded smoothly by controlling reaction temperature, and a series of terphenyls were prepared by one-pot double Suzuki reaction which provided the highest terphenyl yield up to 81% 查看全文查看/发表评论下载PDF阅读器 相关附件：版权转让声明书 -->