Zijian Zhang
Xinlong Luo
Jacob Schrier
Andrew D. Yang
Tao P. Wu
1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;
2 Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA;
3 Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA;
4 Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
Funds: We thank Dr. Andrew Z. Xiao of the Yale University and Dr. Hongjie Li of Baylor College of Medicine for comments on the manuscript. Tao P. Wu is a CPRIT scholar for cancer research. This work is supported by grants from CPRIT (RR180072) and Rivkin Center Scientific Scholar Award.
Received Date: 2021-03-03
Rev Recd Date:2021-07-12
Publish Date:2021-09-27
Abstract
Abstract
N6-methyladenine (N6-mA, m6dA, or 6mA), a prevalent DNA modification in prokaryotes, has recently been identified in higher eukaryotes, including mammals. Although 6mA has been well-studied in prokaryotes, the function and regulatory mechanism of 6mA in eukaryotes are still poorly understood. Recent studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biological processes, from transposable-element suppression to environmental stress response. Here, we review the significant advances in methodology for 6mA detection and major progress in understanding the regulation and function of this non-canonical DNA methylation in eukaryotes, predominantly mammals.Keywords: DNA N6-methyladenine (6mA),
mammalian DNA modification,
non-canonical mammalian DNA methylation
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