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Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

本站小编 Free考研考试/2022-01-02

Yongcun Qu1,2,
Qi Chen3,
Shanshan Guo1,2,
Chiyuan Ma1,
Yonggang Lu4,
Junchao Shi3,
Shichao Liu3,
Tong Zhou5,
Taichi Noda4,
Jingjing Qian1,2,
Liwen Zhang1,2,
Xili Zhu1,
Xiaohua Lei1,
Yujing Cao1,
Wei Li1,9,
Wei Li1,9,
Nicolas Plachta6,
Martin M. Matzuk7,
Masahito Ikawa4,
Enkui Duan1,9,,,
Ying Zhang1,8,9,10,,,
Hongmei Wang1,2,9,,
1 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA;
4 Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan;
5 Department of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA;
6 Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore;
7 Center for Drug Discovery, Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA;
8 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA;
9 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China 10 The Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, Beijing Normal University, Beijing 100875, China
Funds: This work was supported by the National Key Research and Development Program of China (2018YFC1004500 to YZ, 2019YFA0802600 to YZ, 2016YFA0500903 to ED, 2017YFC1001401 to ED, 2015CB943003 to YZ), the Strategic Priority Research Program of the CAS (XDA16020700 to HW) National Basic Research Program of China (81490742 to ED), National Natural Science Foundation of China (81490741 to HW, 31671201 to YZ, 31671568 to ED), Youth Innovation Promotion Association, CAS (Grant No. 2016081 to YZ). The Eunice Kennedy Shriver National Institute of Child Health and Human Development (grants HD088412 and P01HD087157) supports our studies of UTJ migration defects in mouse models. We thank Shiwen Li for the help of image processing.

Publish Date:2021-09-27




Abstract



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