Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in

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Yu Wei1,2,
Yingsi Zhou1,
Yajing Liu1,
Wenqin Ying1,
Ruiming Lv1,
Qimeng Zhao1,2,
Haibo Zhou1,3,
Erwei Zuo4,,,
Yidi Sun1,,,
Hui Yang1,3,,,
Changyang Zhou1,,
1 Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China;
4 Center for Animal Genomics, Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China

Abstract

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http://www.protein-cell.org/article/exportPdf?id=892db128-46e8-40ab-b2ed-821f05fa51ab&language=en

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