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FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocard

本站小编 Free考研考试/2022-01-02

Jinghui Lei1,
Si Wang1,2,5,
Wang Kang4,6,
Qun Chu3,
Zunpeng Liu3,6,
Liang Sun7,
Yun Ji2,5,6,
Concepcion Rodriguez Esteban9,
Yan Yao8,
Juan Carlos Izpisua Belmonte9,
Piu Chan1,
Guang-Hui Liu1,2,5,6,,,
Weiqi Zhang4,5,6,,,
Moshi Song2,5,6,,,
Jing Qu3,5,6,,
1 Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China;
2 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
3 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
4 Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;
5 Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China;
6 University of Chinese Academy of Sciences, Beijing 100049, China;
7 The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China;
8 Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;
9 Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla 92037, USA
Funds: This work was supported by the National Key Research and Development Program of China (2018YFC2000100), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010100), the National Key Research and Development Program of China (2017YFA0102802, 2017YFA0103304, 2018YFA0107203), the National Natural Science Foundation of China (Grant Nos. 81801370, 81625009, 91749202, 81861168034, 81921006, 31671429, 91949209, 91749123, 81671377, 81822018, 81870228, 81922027, 81701388, 81901433, 91849132), the Program of the Beijing Municipal Science and Technology Commission (Z191100001519005), Beijing Natural Science Foundation (Z190019), Beijing Municipal Commission of Health and Family Planning (PXM2018_026283_000002), Advanced Innovation Center for Human Brain Protection (3500-1192012), the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-221), K.C. Wong Education Foundation (GJTD-2019-06, GJTD-2019-08), Youth Innovation Promotion Association of CAS, China Postdoctoral Science Foundation (2018M640154), CAMS Innovation Fund for Medical Sciences (2018-I2M-1-002), the State Key Laboratory of Stem Cell and Reproductive Biology and the State Key Laboratory of Membrane Biology. Work in the laboratory of J.C.I.B. was supported by The Moxie Foundation.






Abstract



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