FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice

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Hongying Gao1,2,
Chunwei Zheng3,
Jian Du4,
Yue Wu1,
Yonghui Sun1,
Chunsheng Han3,5,
Kehkooi Kee4,
Yu Rao1
1 MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry Chemical Biology, Tsinghua University, Beijing 100084, China;
2 Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China;
3 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100084, China;
4 Center for Stem Cell Biology and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;
5 University of Chinese Academy of Sciences, Savaid Medical School, Beijing 100049, China
Funds: This work was supported by the National Natural Science Foundation of China (Grant Nos. 81573277, 81622042, 81773567, and 81811530340), National Major Scientific and Technological Special Project for "Significant New Drugs Development" (Grant Nos. SQ2017ZX095003 and 2018ZX09711001).

Abstract

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http://www.protein-cell.org/article/exportPdf?id=35c2410e-5c9b-4d83-a78b-8c0064a02a91&language=en

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