Yuanlong Ge
Dan Liu
Zhou Songyang
1 State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;
2 Verna and Marrs Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Funds: This study was supported by National Natural Science Foundation of China (Grant Nos. 81871109, 31401223, 81330055, 31570827, 91749113, 91640119 and 31871479)
Natural Science Foundation of Guangdong Province (2017A030313116).
National Key Research and Development Program of China (2017YFA0102801, 2018YFA010 7003)
Received Date: 2019-04-02
Rev Recd Date:2019-05-07
Publish Date:2020-01-10
Abstract
Abstract
Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs), ESCs derived by somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have unlimited capacity for self-renewal and pluripotency and can give rise to all types of somatic cells. In order to maintain their self-renewal and pluripotency, PSCs need to preserve their telomere length and homeostasis. In recent years, increasing studies have shown that telomere reprogramming is essential for stem cell pluripotency maintenance and its induced pluripotency process. Telomere-associated proteins are not only required for telomere maintenance in both stem cells, their extra-telomeric functions have also been found to be critical as well. Here, we will discuss how telomeres and telomere-associated factors participate and regulate the maintenance of stem cell pluripotency.Keywords: telomere,
pluripotent stem cells,
telomerase,
ALT,
shelterin/telosome complex
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