Xuetao Ji
Qian Wang
ZhongJohn Li
1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China
2. Jiangsu Province Key Laboratory of Human Functional Genomics, Nanjing Medical University, Nanjing 211166, China
Funds: the National Natural Science Foundation of China81271828
the National Basic Research Program (973 Program)2013CB530600
the National Natural Science Foundation of China31271268
the National Natural Science Foundation of China81471079
a Technology/Development Fund of Nanjing Medical University2016NJMU004
the National Basic Research Program (973 Program)2012CB517503
More InformationCorresponding author: Qian Wang, wqian@njmu.edu.cn;John Zhong Li, lizhong@njmu.edu.cn
Received Date: 2017-03-17
Accepted Date:2017-05-31
Publish Date:2018-01-01
Abstract
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and a significant global health problem with substantial rise in prevalence over the last decades. It is becoming increasingly clear that NALFD is not only predominantly a hepatic manifestation of metabolic syndrome, but also involves extra-hepatic organs and regulatory pathways. Therapeutic options are limited for the treatment of NAFLD. Accordingly, a better understanding of the pathogenesis of NAFLD is critical for gaining new insight into the regulatory network of NAFLD and for identifying new targets for the prevention and treatment of NAFLD. In this review, we emphasize on the current understanding of the inter-organ crosstalk between the liver and peripheral organs that contributing to the pathogenesis of NAFLD.Keywords: non-alcoholic fatty liver disease,
hepatic lipid metabolism,
hypothalamus,
gut-liver axis,
adipose tissue
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