Expansion of Redox Chemistry in Designer Metalloenzymes
Yang Yu, Xiaohong Liu, and Jiangyun Wang
Abstract
Many artificial enzymes that catalyze redox reactions have important energy, environmental, and medical applications. Native metalloenzymes use a set of redox-active amino acids and cofactors as redox centers, with a potential range between ？700 and +800 mV versus standard hydrogen electrode (SHE, all reduction potentials are versus SHE). The redox potentials and the orientation of redox centers in native metalloproteins are optimal for their redox chemistry. However, the limited number and potential range of native redox centers challenge the design and optimization of novel redox chemistry in metalloenzymes. Artificial metalloenzymes use non-native redox centers and could go far beyond the natural range of redox potentials for novel redox chemistry. In addition to designing protein monomers, strategies for increasing the electron transfer rate in self-assembled protein complexes and protein–electrode or ？nanomaterial interfaces will be discussed.
文章链接：https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.accounts.8b00627
附件下载：